Objective To evaluate the antibacterial efficacy of ceftobiprole,vancomycin,linezolid,and daptomycin against Staphylococcus aureus(SAU)and coagulasenegative Staphylococcus(CNS)bloodstream infections,which can provide ...
Objective To develop an area under curve (AUC)-based nomogram to predict vancomycin-associated nephrotoxicity in critically ill patients.Methods This retrospective cohort study included adult patients treated with van...
Supported by Shantou Medical and Health Science and Technology Program;No. SFK [2020] 66-23
BACKGROUND Vancomycin remains a first-line treatment drug as per the treatment guidelines for methicillin-resistant Staphylococcus aureus(MRSA)bacteremia.However,a number of gram-positive cocci have developed resistan...
Universiti Kebangsaan Malaysia’s research university grant scheme (DCP-2017- 003/4)。
This study focused on the encapsulation of vancomycin(VAN) into liposomes coated with a red blood cell membrane with a targeting ligand, daptomycin–polyethylene glycol–1,2-distearoyl-sn-glycero-3-phosphoethanolamine...
This work was supported by grants from Ruijin Hospital,Affiliated to Shanghai Jiao Tong University School of Medicine(No.2018ZY04 and No.2019ZY22);the Shanghai Jiading District Health Commission(No.2019-QN-04)。
Background:Vancomycin treatment failure against vancomycin-susceptible gram-positive cocci is not rare in the intensive care unit(ICU).One of the reasons for this is the substandard drug trough concentration.We aimed ...
The clinical manifestations of neonatal GBS meningitis are as follows:non-specificity,long hospital stay,easy to cause neurological complications,and sequelae.Clinical pharmacist participated in the anti-infective tre...
the National Natural Science Foundation of China(No.81873059&81673662);the National Key Research and Development Program of China(No.2017YFC1700200);Shuguang Scholar(16SG36)at Shanghai Institutions of Higher Learning from Shanghai Municipal Education Commission。
Liver injury caused by acetaminophen(AP)overdose is a leading public health problem.Although APinduced liver injury is well recognized as the formation of N-acetyl-p-benzoquinone(NAPQI),a toxic metabolite of AP,result...
The original online version of this article (Hamdan, E.M. and AL-Attas, M. (2017) Linezolid versus Vancomycin for the Treatment of Methicillin-Resistant Staphylococcus aureus in Hospital-Acquired, Ventilator-...
Fujian Medical Innovation Project(Grant No.2017-CX-31);Guidance Project of Fujian Science and Technology Department(Grant No.2017Y0033).
Clinical guidelines recommend a steady-state vancomycin(VCM)trough concentration(SVTC)of 10–15 mg/L for regular infections and 15–20 mg/L for severe infections.However,clinical trials have shown that increasing SVTC...
Guidance Project of Fujian Science and Technology Department(Grant No.2017Y0033);Fujian Medical Innovation Project(Grant No.2017-CX-31);Sail Project of Fujian Medical University(Grant No.2017XQ1068);“Weak Discipline Construction Project” of Shanghai Municipal Commission of Health and Family Planning(Grant No.2016ZB0301-01).
In the present study, we aimed to develop a population pharmacokinetics(PPK) model of vancomycin(VCM) and propose the individualised dosage regimen for Chinese elderly patients. The data were collected prospectively f...