WHOLE-CELL

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Efficient conversion of aromatic and phenylpropanoid alcohols to acids by the cascade biocatalysis of alcohol and aldehyde dehydrogenases
《Synthetic and Systems Biotechnology》2024年第2期187-195,共9页Zetian Qiu Xiaohui Liu Jie Yu Yushuo Zhao Guang-Rong Zhao Shengying Li Kun Liu Lei Du Li Ma 
This work was supported by the National Key Research and Development Program of China(2021YFA0911500);the National Natural Science Foundation of China(32071266,32170088,and 32370032);the Shandong Provincial Natural Science Foundation(ZR2020ZD23);the State Key Laboratory of Microbial Technology Open Projects Fund(M2022-01).
Benzyl and phenylpropanoid acids are widely used in organic synthesis of fine chemicals,such as pharmaceuticals and condiments.However,biocatalysis of these acids has received less attention than chemical synthesis.On...
关键词：Benzyl acids Phenylpropanoid acids Alcohol dehydrogenases Aldehyde dehydrogenases Whole-cell catalysis 
Artificial multi-enzyme cascades and whole-cell transformation for bioconversion of C1 compounds: Advances, challenge and perspectives
《Synthetic and Systems Biotechnology》2023年第4期578-583,共6页Yangyi Qiao Wenyue Ma Shangjie Zhang Feng Guo Kang Liu Yujia Jiang Yanxia Wang Fengxue Xin Wenming Zhang Min Jiang 
supported by National Key R&D Program of China(2022YFC2105900);the National Natural Science Foundation of China(22078151,22378199,21978130);Jiangsu Natural Science Fund for Distinguished Young Scholars(BK20220052)the Jiangsu Synergetic Innovation Center for Advanced Bio-Manufacture(XTD2215);Young Elite Scientist Sponsorship Program by CAST(YESS20200174).
Artificial multi-enzyme cascades bear great potential for bioconversion of C1 compounds to value-added chemicals.Over the past decade,massive efforts have been devoted to constructing multi-enzyme cascades to produce ...
关键词：SCALING PROOF utilizing 
Efficient stereoselective hydroxylation of deoxycholic acid by the robust whole-cell cytochrome P450 CYP107D1 biocatalyst被引量：1
《Synthetic and Systems Biotechnology》2023年第4期741-748,共8页Chixiang Sun Baodong Hu Yanchun Li Zhimeng Wu Jingwen Zhou Jianghua Li Jian Chen Guocheng Du Xinrui Zhao 
supported by the National Key Research and Development Program of China(2019YFA0906400);the National First-class Discipline Program of Light Industry Technology and Engineering(LITE2018-08);Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX23_2486);We thank Prof.Shengying Li(Shandong University,China)for providing plasmids pET28a-SelFdx1499 and pET28a-SelFdR0978.
Deoxycholic acid(DCA)has been authorized by the Federal Drug Agency for cosmetic reduction of redundant submental fat.The hydroxylated product(6β-OH DCA)was developed to improve the solubility and pharmaceutic proper...
关键词：OleP Deoxycholic acid HYDROXYLATION Redox partners Whole-cell catalysis 
Whole‑cell catalytic synthesis of trehalose by Corynebacterium glutamicum displaying trehalose synthase on its cell surface
《Systems Microbiology and Biomanufacturing》2023年第3期489-497,共9页Ming Fang Qiang Wang Zhi Wang Ruiqi Lu Rufan Xing Xian Zhang Zhiming Rao 
the National Natural Science Foundation of China(No.32171471);Key Research and Development Project of Shandong Province,China(2019JZZY020605);the Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions,Top-notch Academic Programs Project of Jiangsu Higher Education Institutions.
Trehalose is a disaccharide with many applications in cosmetics,refrigeration,and food.Trehalose synthase is a significant enzyme in trehalose production.Escherichia coli is usually used to express this enzyme heterol...
关键词：Trehalose synthase Corynebacterium glutamicum Surface display Whole-cell catalyses 
Integrative modeling of the cell
《Acta Biochimica et Biophysica Sinica》2022年第9期1213-1221,共9页Xianni Zhong Jihui Zhao Liping Sun 
the grant from Shanghai Frontiers Science Center for Biomacromolecules and Precision Medicine at ShanghaiTech University,Shanghai Municipal Government and ShanghaiTech University.
A whole-cell model represents certain aspects of the cell structure and/or function.Due to the high complexity of the cell,an integrative modeling approach is often taken to utilize all available information including...
关键词：whole-cell modeling integrative modeling compartment model cell biology 
Cell surface protein engineering for high-performance whole-cell catalysts被引量：1
《Frontiers of Chemical Science and Engineering》2017年第1期46-57,共12页Hajime Nakatani Katsutoshi Hori 
Cell surface protein engineering facilitated by accumulation of information on genome and protein structure involves heterologous production and modifica- tion of cell surface proteins using genetic engineering, and i...
关键词：cell surface engineering surface display whole-cell catalysts BIOPROCESS 
Optimization of Two-species Whole-cell Immobilization System Constructed with Marine-derived Fungi and Its Biological Degradation Ability被引量：5
《Chinese Journal of Chemical Engineering》2014年第2期187-192,共6页陈慧英 王明霞 沈煜斌 姚善泾 
Supported by the National Natural Science Foundation of China(21036005);Scientific Technology Program of Zhejiang Province(2011C33016)
Mycelia pellet formed spontaneously in the process of cultivation was exploited as a biological carrier for whole-cell immobilization due to its unique structural characteristic. An innovative two-species whole-cell i...
关键词：whole-cell immobilization mycelia pellet Pestalotiopsis sp. Penicillium janthinellum biodegradation kinetics biological wastewater treatment 
AIIocryptopine and benzyltetrahydropalmatine block hERG potassium channels expressed in HEK293 cells被引量：5
《Acta Pharmacologica Sinica》2013年第6期847-858,共12页Kun LIN Yu-qi LIU Bin XU Jin-liao GAO Yi-cheng FU Yu CHEN Qiao XUE Li YANG 
This study was supported by grants from the National Natural Science Foundation of China （No 81170177, No 30770901）. The authors would like to thank Prof Silvia G PRIORI from Molecular Cardiology, Fondazione Salvatore Maugeri IRCCS, at the University of Pavia in Italy for generously providing the hERG plasmid.
Aim： AIIocryptopine （ALL） is an alkaloid extracted from Corydalis decumbens （Thunb） Pers. Papaveraceae, whereas benzyltetrahydropalmatine （BTHP） is a derivative of tetrahydropalmatine extracted from Corydalis a...
关键词：allocryptopine benzyltetrahydropalmatine hERG current whole-cell patch-clamp recording anti-arrhythmic agent 
Effect of the ginsenoside Rb1 on the spontaneous contraction of intestinal smooth muscle in mice被引量：3
《World Journal of Gastroenterology》2012年第38期5462-5469,共8页Lei Xu Sui-Ping Huang 
Supported by The National Natural Science Foundation of China, No. 30873328;The State Administration of Traditional Chinese Medicine of the People’s Republic of China, No. 06-075930
AIM: To investigate the effect and the possible mechanism of ginsenoside Rb1 on small intestinal smooth muscle motility in mice. METHODS: Intestinal smooth muscle strips were isolated from male ICR mice (5 wk old), an...
关键词：Ginsenoside Rb1 Intestinal smooth muscle Intestinal smooth muscle cell Potassium channel Spontaneous contraction Whole-cell patch clamp technique 
Adjuvant immunotherapy with whole-cell lysate dendritic cells vaccine for glioblastoma multiforme： a phase II clinical trial被引量：2
《中国神经肿瘤杂志》2012年第3期172-172,共1页
关键词：树突状细胞 免疫治疗 细胞疫苗 母细胞 多形性 临床试验 细胞裂解 胶质 
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