ADP-RIBOSYLATION

作品数：11被引量：23H指数：4
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相关领域：生物学医药卫生更多>>
相关机构：福州大学河南大学更多>>
相关期刊：《生物物理学报》《Acta Biochimica et Biophysica Sinica》《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》《mLife》更多>>
相关基金：国家自然科学基金更多>>
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Reversing metabolic reprogramming by CPT1 inhibition with etomoxir promotes cardiomyocyte proliferation and heart regeneration via DUSP1 ADP-ribosylationmediated p38 MAPK phosphorylation
《Acta Pharmaceutica Sinica B》2025年第1期256-277,共22页Luxun Tang Yu Shi Qiao Liao Feng Wang Hao Wu Hongmei Ren Xuemei Wang Wenbin Fu Jialing Shou Wei Eric Wang Pedro AJose Yongjian Yang Chunyu Zeng 
supported by grants from the National Key Research and Development Program of China(No.2022YFA1104500);National Natural Science Foundation of China(No.81930008);Natural Science Foundation of Sichuan Province(No.2023NSFSC1651,China);the National Institutes of Health(No.DK134574 and No.DK119652,US).
The neonatal mammalian heart has a remarkable regenerative capacity,while the adult heart has difficulty to regenerate.A metabolic reprogramming from glycolysis to fatty acid oxidation occurs along with the loss of ca...
关键词：Metabolic reprogramming Cardiomyocyte proliferation Carnitine palmitoyltransferase l ETOMOXIR Fatty acid oxidation GLYCOLYSIS ADP-RIBOSYLATION p38MAPK 
ARTC1-mediated VAPB ADP-ribosylation regulates calcium homeostasis
《Journal of Molecular Cell Biology》2023年第7期1-14,共14页Xueyao Ma Mengyuan Li Yi Liu Xuefang Zhang Xiaoyun Yang Yun Wang Yipeng Li Jiayue Wang Xiuhua Liu Zhenzhen Yan Xiaochun Yu Chen Wu 
This work was supported by grants from the National Natural Science Foundation of China(32071277,82002594,81874160,and 32171295);the Natural Science Foundation of Hebei Province(C2021201012);S&T Program of Hebei(216Z2602G);the Interdisciplinary Research Program of Natural Science of Hebei University(DXK202006 and DXK202007);Hebei Natural Science Foundation for Outstanding Young Scholars(H2020201017);the High-level Talents Research Start-up Project of Hebei University(521000981352).
Mono-ADP-ribosylation(MARylation)is a post-translational modification that regulates a variety of biological processes,including DNA damage repair,cell proliferation,metabolism,and stress and immune responses.In mamma...
关键词：ATRCs mono-ADP-ribosylation hARTC1 VAPB calcium homeostasis 
Legionella pneumophila temporally regulates the activity of ADP/ATP translocases by reversible ADP-ribosylation被引量：4
《mLife》2022年第1期51-65,共15页Jiaqi Fu Pengwei Li Hongxin Guan Dan Huang Lei Song Songying Ouyang Zhao-Qing Luo 
supported by National Institutes of Health grant R01AI127465(Zhao-Qing Luo);the National Nature Science Foundation of China grants 82172287,31770948(Songying Ouyang)and 32171265(Hongxin Guan);the Fujian Provincial Department of Science and Technology(2020Y4007,2021H0004)(Songying Ouyang);the High-level personnel introduction grant of Fujian Normal University(Z0210509)(Songying Ouyang).
The mitochondrion is an important signaling hub that governs diverse cellular functions,including metabolism,energy production,and immunity.Among the hundreds of effectors translocated into host cells by the Dot/Icm s...
关键词：energy metabolism metaeffector MITOCHONDRIA type IV secretion 
ADP-ribosylhydrolases:from DNA damage repair to COVID-19
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2021年第1期21-30,共10页Lily YU Xiuhua LIU Xiaochun YU 
supported by the National Natural Science Foundation of China(No.81874160);the Foundation of Hebei Educational Committee(No.ZD2020183);the Ministry of Education Chunhui Project;the Hebei Province Foundation for Returned Overseas Chinese Scholars(No.C20200303);the research funds from Westlake University,Hangzhou,China。
Adenosine diphosphate(ADP)-ribosylation is a unique post-translational modification that regulates many biological processes,such as DNA damage repair.During DNA repair,ADP-ribosylation needs to be reversed by ADP-rib...
关键词：DNA damage repair Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) Adenosine diphosphate(ADP)-ribosylation Macrodomain ADP-ribosylhydrolase deADP-ribosylation 
Alteration of ADP-ribosylation in aging rat brain astrocytes被引量：1
《BIOCELL》2019年第1期37-40,共4页Manoochehr MESSRIPOUR Azadeh MESRIPOUR 
DNA damage and the enzyme poly(ADP-ribose)polymerase(PARP)associated with the pathogenesis of numerous age-related neurodegenerative disorders.Astrocytes play crucial roles in both support metabolic functions and cell...
关键词：ADP-ribosyl polymerase DNA damages Glutamine synthetase 
Destabilization of linker histone H1.2 is essential for ATM activation and DNA damage repair被引量：4
《Cell Research》2018年第7期756-770,共15页Zhiming Li Yinglu Li Ming Tang Bin Peng Xiaopeng Lu Qiaoyan Yang Qian Zhu Tianyun Hou Meiting Li Chaohua Liu Lina Wang Xingzhi Xu Ying Zhao Haiying Wang Yang Yang Wei-Guo Zhu 
The authors are grateful to Dr. Tanya Paull （University of Texas, USA） and Dr. Fabrizio d＇Adda di Fagagna （FIRC Institute of Molecular Oncology Foundation, Italy） for kindly providing the ATM plasmids; to Dr. Junjie Chen （MD Anderson Cancer Center, USA） for kindly providing NBSI KO HeLa cells and to Dr. Jessica Tamanini for editing the manuscript prior to submission. This study was supported by the National Key R＆D Program of China （grant number 2017YFA0503900） and the National Natural Science Foundation of China （grant numbers 81621063, 81530074, 31570812 and 81720108027）, and the Shenzhen Municipal Commission of Science and Technology Innovation （grant numbers JCYJ20160427104855100 and JCYJ201708180924S0901）.
Linker histone HI is a master regulator of higher order chromatin structure, but its involvement in the DNA damage response and repair is unclear. Here, we report that linker histone H1.2 is an essential regulator of ...
关键词：DNA damage response PolyADP-ribosylation 
Poly（ADP-ribose） mediates asymmetric division of mouse oocyte被引量：2
《Cell Research》2018年第4期462-475,共14页Bingteng Xie Lu Zhang Huiling Zhao Qingyun Bai Yong Fan Xiaohui Zhu Yang Yu Rong Li Xin Liang Qing-Yuan Sun Mo Li Jie Qiao 
We are grateful to Dr. Bo Xiong for the insightful comments and suggestions on the manuscript. This work was supported by the grants from ＂Reproductive health and major birth defects prevention and control research＂ of Key Special Fund （2016YFCI000604）, ＂Mechanism and clinical application of oocyte in vitro maturation＂ of Key Special Fund （2017YFCI001501）, and the Foundation for Innovative Research Groups of the National Natural Science Foundation of China （81521002）. M. L. is a member of Thousand Young Talents Program of China,
Before fertilization, mammalian oocyte undergoes an asymmetric division which depends on eccentric positioning of the spindle at the oocyte cortex to form a polar body and an egg. Since the centriole is absent and, as...
关键词：MEIOSIS PolyADP-ribosylation 
A unique deubiquitinase that deconjugates phosphoribosyl-linked protein ubiquitination被引量：4
《Cell Research》2017年第7期865-881,共17页Jiazhang Qiu Kaiwen Yu Xiaowen Fei Yao Liu Emesto S Nakayasu Paul D Piehowski Jared B Shaw Kedar Puva Chittaranjan Das Xiaoyun Liu Zhao-Qing Luo 
We thank Dr Peter Hollenbeck and Dr Arthur Aronson （Purdue University） for critical reading of the manuscript. We also thank members of the Luo laboratory for helpful discussion. Portions of this work were supported by intemal research fund from the First Hospital of Jilin University; A Team of Science Incentive Grant from PI4D, Purdue University, National Institutes of Health grants R21AI105714 （ZQL）, R01GM103401 （CD） and GM103493 and by National Natural Science Foundation of China grants 21475005 and 21622501 （XL）.
Ubiquitination regulates many aspects of host immunity and thus is a common target for infectious agents. Recent studies have revealed that members of the SidE effector family of the bacterial pathogen Legionella pneu...
关键词：LEGIONELLA bacterial effectors ADP-RIBOSYLATION PHOSPHODIESTERASE 
Functions of PARylation in DNA Damage Repair Pathways被引量：8
《Genomics, Proteomics & Bioinformatics》2016年第3期131-139,共9页Huiting Wei Xiaochun Yu 
funded by the National Institutes of Health of the United States(Grant Nos.CA132755,CA187209,and GM108647)
Protein poly ADP-ribosylation（PARylation） is a widespread post-translational modification at DNA lesions,which is catalyzed by poly（ADP-ribose） polymerases（PARPs）.This modification regulates a number of biologic...
关键词：Poly ADP-ribosylation PARPs DNA damage response PAR-binding modules Ubiquitination 
A SIRT4-1ike auto ADP,ribosyltransferase is essential for the environmental growth of Mycobacterium smegmatis被引量：1
《Acta Biochimica et Biophysica Sinica》2016年第2期145-152,共8页Yongcong Tan Zhihong Xu Jing Tao Jinjing Ni Wei Zhao Jie Lu Yu-Feng Yao 
SIRT family proteins are highly conserved both in the structure and function among all the organisms, and are involved in gene silencing, DNA damage repair, cell growth and metabolism. Here, a SIRT4 homologue MSMEG_46...
关键词：MSMEG_4620 auto ADP-ribosylation DEACETYLATION SIRT4 environmental mycobacteria 
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