Parkinson's disease(PD)is a neurodegenerative disorder characterized by progressive motor disturbances and affects more than 1%of the worldwide population.Diagnosis of PD relies on clinical history and physical examin...
We would like to acknowledge financial supports by the National Natural Science Foundation(81430025,81701265,31800898,U801681);Acknowledgements are also to the supports of the Swedish Research Council(K2015-61X-22297-03-4);EU-JPND(aSynProtec),EU-JPND(REfrAME),EU H2020-MSCA-ITN-2016(Syndegen),BAGADILICO-Excellence in Parkinson and Huntington Research,the Strong Research Environment MultiPark(Multidisciplinary research on Parkinson’s disease),the Swedish Parkinson Foundation(Parkinsonfonden),Torsten Söderbergs Foundation,Olle Engkvist Byggmästere Foundation;W.L.is supported by a scholarship from the China Scholarship Council;TFO is supported by the DFG Center for Nanoscaly Microscopy and Molecular Physiology of the Brain(CNMPB).
Background:Progressive accumulation ofα-synuclein is a key step in the pathological development of Parkinson’s disease.Impaired protein degradation and increased levels ofα-synuclein may trigger a pathological aggr...
The works were supported by National Natural Science Foundation of China(Grant No.31371400)(Q.Y)and(Grant No.31671060)(Q.Y).
Parkinson’s disease(PD)is the second most common neurodegenerative disease.Increasing evidence supports that dysregulation of autophagy and mitochondrial function are closely related with PD pathogenesis.In this revi...