PHOSPHODIESTERASES

作品数：8被引量：5H指数：2
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相关领域：医药卫生更多>>
相关作者：陆红丽张汉霆更多>>
相关机构：西弗吉尼亚大学泰山医学院上海交通大学更多>>
相关期刊：《The Crop Journal》《Journal of Biomedical Science and Engineering》《Cell Research》《中国药理学与毒理学杂志》更多>>
相关基金：国家自然科学基金更多>>
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Regulation by phosphodiesterase of anxiety-and depressive-like behavior induced by alcohol withdrawal in mice
《中国药理学与毒理学杂志》2021年第9期667-668,共2页LIU Xiao-qian WANG Dong ZHENG Wen-qing ZHANG Fang-fang ZHANG Han-ting 
OBJECTIVE Alcohol dependence is not only the most common public health prob⁃lem worldwide,but also the cause of many alco⁃hol-related diseases,such as anxiety and depres⁃sion.However,the mechanism of these comor⁃bidit...
关键词：PHOSPHODIESTERASES alcohol with⁃drawal behavior 
Identification of two glycerophosphodiester phosphodiesterase genes in maize leaf phosphorus remobilization被引量：2
《The Crop Journal》2021年第1期95-108,共14页Jingxin Wang Wenbo Pan Alexiy Nikiforov William King Wanting Hong Weiwei Li Yang Han Jana Patton-Vogt Jianbo Shen Lingyun Cheng 
supported by the National Key Research and Development Program of China(2017YFD0200204);the National Natural Science Foundation of China(31972496,31572190);the Deutsche Forschungsgemeinschaft(328017493/GRK2366);the National Institutes of Health Grant(R15 GM 104876)to Jana Patton-Vogt。
Phosphate deficiency is one of the leading causes of crop productivity loss.Phospholipid degradation liberates phosphate to cope with phosphate deficiency.Glycerophosphodiester phosphodiesterases(GPX-PDEs)hydrolyse th...
关键词：Glycerophosphodiester PHOSPHODIESTERASES MAIZE Phosphate deficiency Phosphorus remobilization PHOSPHOLIPID 
Targeting phosphodiesterases for cognition enhancement:a translational approach
《中国药理学与毒理学杂志》2017年第5期453-454,共2页Jos PRICKAERTS 
Cyclic adenosine monophosphate(cA MP) and/or cyclic guanosine monophosphate(cG MP)have been suggested to play specific roles in processes of memory. These cyclic nucleotides are hydrolyzed by specific enzymes,ie phosp...
关键词：PHOSPHODIESTERASES COGNITION MEMORY 
Phosphodiesterases:novel targets for treatment of alcoholism
《中国药理学与毒理学杂志》2017年第5期454-455,共2页LIU Xin WEN Rui-ting GONG Mei-fang XU Ying Nicolas GRAHAME XU Jiang-ping LIANG Jian-hui Marco CONTI 张汉霆 
OBJECTIVE Alcoholism is one of the most damaging psychiatric disorders and causes serious social and health problems in the world. However,there are no ideal treatments for this disease in clinic.Phosphodiesterases(PD...
关键词：PHOSPHODIESTERASE alcohol drinking ALCOHOLISM ANXIETY DEPRESSION RODENTS 
Regulation and function of cyclic nucleotide phosphodiesterases in pathological vascular remodeling
《中国药理学与毒理学杂志》2017年第5期456-457,共2页YAN Chen 
Pathological vascular remodeling is characterized by thickening or thinning of the vessel wall through altering cellular and non-cellular components,which associates with various blood circulation disorders in brain,h...
关键词：PHOSPHODIESTERASES smooth muscle cells vascular remodeling 
环核苷酸磷酸二酯酶:神经精神疾病的药物作用靶标(英文)
《中国药理学与毒理学杂志》2017年第5期448-449,共2页James M.O′DONNELL 
OBJECTIVE To investigate the relationship between the neurochemical and behavioral effects of inhibitors of cyclic nucleotide phosphodiesterases 2(PDE2) and PDE4 in the hope of identifying promising therapeutic target...
关键词：phosphodiesterases 4 phosphodiesterases 2 ANTIDEPRESSANT ANXIOLYTIC MEMORY 
Identification and characterization of phosphodiesterases that specifically degrade 3＇3＇-cyclic GMP-AMP被引量：3
《Cell Research》2015年第5期539-550,共12页Juyi Gao Jianli Tao Weili Liang Meng Zhao Xiaoxia Du Shan Cui Haifeng Duan Biao Kan Xiaodong Su Zhengfan Jiang 
We thank Dr Yulong Li for critical discussion and Dr Zhijian J Chen for human cGAS expression vector and helpful technical assistance. This work was supported by the National Natural Science Foundation of China （31025010, 31230023, 81171640 and 91129000）, and the Chinese Ministry of Science and Technology （2011CB911103 and 2014CB542600）.
Cyclic dinucleotides act as intracellular second messengers, modulating a variety of cellular activities including innate immune activation. Although phosphodiesterases （PDEs） hydrolyzing c-di-GMP and c-di-AMP have ...
关键词：3＇3＇-cGAMP V. cholera PHOSPHODIESTERASE HD-GYP 
Cyclic nucleotide phosphodiesterase 3B is connected to osteopontin and protein kinase CK2 in pancreatic <i>β</i>-cells
《Journal of Biomedical Science and Engineering》2013年第5期73-84,共12页Emilia Heimann Amitabh Sharma Nalini Raghavachari Vincent C. Manganiello Lena Stenson Eva Degerman 
Islets from RIP-PDE3B mice, exhibiting β-cell specific overexpression of the cAMP/cGMP-degrading enzyme phosphodiesterase 3B (PDE3B) and dysregulated insulin secretion, were subjected to microarray analysis. We show ...
关键词：Diabetes Mellitus PANCREATIC ISLETS β-Cells cAMP Cyclic Nucleotide PHOSPHODIESTERASES PDE OSTEOPONTIN Protein Kinase CK2 
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