LIPID-LOWERING

作品数：43被引量：129H指数：5
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Hymoins A–C,three unusual polycyclic polyprenylated acylphloroglucinols with lipid-lowering activity from Hypericum monogynum
《Chinese Chemical Letters》2025年第3期411-414,共4页Chunmao Yuan Yanrong Zeng Lei Huang Yu Mou Jun Jin Ping Yi Yanmei Li Xiaojiang Hao 
financially supported by the National Natural Science Foundation of China(Nos.32270413,82060631,82160808,and 82360035);the Science and Technology Department of Guizhou Province(Nos.QKHJC 2020–1Z076,QKHJC-ZK[2023]YB156,QKHJC-ZK[2021]YB569,and QKHPTRC[2020]5008);Excellent Young Talents Plan of Guizhou Medical University(2023,No.106);the 13thbatch of outstanding young scientific and technological talents in Guizhou Province(No.QKHPTRC[2021]5633);Guizhou Science and Technology Innovation Talent Team(No.QKHPTRC–CXTD[2022]007);High-level Innovative Talents in Guizhou Province(Thousand Levels of Talent for Chunmao Yuan in 2018);the project of State Key Laboratory of Functions and Applications of Medicinal Plants,Guizhou Medical University(Nos.FAMP202102K and QJJ[2023]113)。
Hymoins A–C(1–3),three unusual polycyclic polyprenylated acylphloroglucinols(PPAPs)were isolated from the flowers of Hypericum monogynum.Hymoin A features the first intriguing 6/5/5/5/7 pentacyclic caged PPAP.Hymoin...
关键词：Hypericum monogynum Polycyclic polyprenylated ACYLPHLOROGLUCINOLS Structure elucidation Lipid-lowering activity Mechanistic study 
A systematic,updated review of Xuezhikang,a domestically developed lipid-lowering drug,in the application of cardiovascular diseases被引量：1
《Acta Pharmaceutica Sinica B》2024年第10期4228-4242,共15页Cheng Yang Yongjian Wu Jie Qian Jian-Jun Li 
supported by the CAMS Innovation Fund for Medical Sciences(CIFMS)(2022-12M-C&T-B-043,China).
Cardiovascular diseases(CVDs)are a major threat to public health globally.A large proportion of people with dyslipidaemia have poorly controlled lipid levels,emphasizing the need for alternative lipid-lowering treatme...
关键词：Red yeast rice Xuezhikang Natural extract Traditional Chinese medicine Cardiovascular disease DYSLIPIDAEMIA LIPID-LOWERING Cardiovascular prevention 
(+)/(-)-Mycosphatide A,a pair of highly oxidized polyketides with lipid-lowering activity from the mangrove endophytic fungus Mycosphaerella sp.SYSU-DZG01
《Chinese Chemical Letters》2024年第9期210-213,共4页Qi Tan Run-Zhu Fan Wencong Yang Ge Zou Tao Chen Jianying Wu Bo Wang Sheng Yin Zhigang She 
National Natural Science Foundation of China(Nos.U20A2001,81973195,21877133);the Guangdong Marine Economy Development Special Project(Nos.GDNRC[2022]35,GDNRC[2023]39)。
(±)-Mycosphatide A(1a/1b),a pair of highly oxidized enantiomeric polyketides featuring a unique5/5/6/5-fused tetracyclic ring system,were isolated from the mangrove endophytic fungus Mycosphaerella sp.SYSU-DZG01.Thei...
关键词：Mangrove endophytic fungus Mycosphaerella sp. Polyketide Highly oxidized Lipid-lowering activity 
Influences of Lactiplantibacillus plantarum and Saccharomyces cerevisiae fermentation on the nutritional components,flavor property and lipid-lowering effect of highland barley被引量：1
《Journal of Future Foods》2024年第3期258-266,共9页Juan Bai Linzhao He Jinfu Zhang Xiangyue Gu Beiqi Wu Anlin Wang Ying Zhu Jiayan Zhang Yansheng Zhao Jie Yuan Xiang Xiao 
supported by the China Postdoctoral Science Foundation(2020M671373);Jiangsu Postdoctoral Research Funding Program(2020Z070);Jiangsu Agriculture Science and Technology Innovation Fund(CX(20)2036);Key Research and Development Project of Jiangsu Province(BE2020314);Innovation Training Program for College Students(202310299649X).
Highland barley is a well-known cereal in Qinghai-Tibet Plateau area with high nutritional value,which has been reported to be a health-promoting grain for the obesity and the diabetes.Fermentation by certain microbio...
关键词：Highland barley Lactiplantibacillus plantarum Saccharomyces cerevisiae FERMENTATION Flavor property LIPID-LOWERING 
Lipid-lowering effects of gefarnate in statin-treated patients with residual hypertriglyceridemia:a randomized controlled study
《Journal of Geriatric Cardiology》2024年第8期791-798,共8页Jing SHI Ming-Lu XU Mei-Jiao HE Wan-Lan BO Hai-Yu ZHANG Dang-Hui SUN Ding-Yu WANG Xiao-Yu WANG Qun SHAO Yu-Jiao PAN Yu ZHANG Chen-Guang DAI Jing-Ying WANG Lin-Wei ZHANG Guang-Zhong LIU Yue LI for the GPROT Study Group 
supported by the State Key Program of National Natural Science Foundation of China(No.82330014);the Youth Program of the National Natural Science Foundation of China(No.81900374&No.82100455);the Postdoctoral Science Foundation of Heilongjiang Province(LBH-Z20175);the Key Research and Development Plan of Heilongjiang Province(2022ZX06C23&JD2023SJ44);the Outstanding Youth Science Foundation in the First Affiliated Hospital of Harbin Medical University(HYD2020YQ0002&HYD2024YQ16)。
BACKGROUND The prevention of coronary artery disease(CAD)faces dual challenges:the aspirin-induced gastrointestinal injury,and the residual cardiovascular risk after statin treatment.Geraniol acetate(Gefarnate)is an a...
关键词：NAT ALONE LIPID 
Lipids,lipid-lowering drug and sepsis:a Mendelian randomization study
《Medical Data Mining》2024年第2期17-26,共10页Qiu-Lan Mo Rong-Hui Wang Qiu-Gui Wei Zu-Lu Liu 
The 2022 Educational Teaching Reform and Research Project of Guangxi University of Traditional Chinese Medicine(2022C032).
lipid-lowering interventions on the disease.Methods:Two-sample Mendelian randomization analyses were conducted to evaluate the associations of high-density lipoprotein cholesterol,low-density lipoprotein cholesterol,t...
关键词：LIPID lipid-lowering drug SEPSIS Mendelian randomization 
(+)/(-)-Gerbeloid A,a pair of unprecedented coumarin-based polycyclic meroterpenoid enantiomers from Gerbera piloselloides:Structural elucidation,semi-synthesis,and lipid-lowering activity
《Acta Pharmaceutica Sinica B》2024年第6期2657-2668,共12页Chenxu Zhao Jingrong Li Yue Hu Lingyu Li Meng Yu Yunfeng Huang Tao Zhang Hai Shang Zhongmei Zou 
support from the Natural Sciences Foundation of China(82374035);the CAMS Innovation Fund for Medical Sciences(CIFMS,2022-I2M-1-017,China).
A pair of coumarin-based polycyclic meroterpenoid enantiomers(+)/(-)-gerbeloid A[(+)-1a and(-)-1b]were isolated from the medicinal plant Gerbera piloselloides,which have a unique caged oxatricyclo[4.2.2.0^(3,8)]decene...
关键词：Gerbera piloselloides Natural products Coumarin meroterpenoid Structural elucidation Biomimetic synthesis Lipid-lowering activity 3T3-L1 adipocytes High-fat diet zebrafish model 
Chlorajaponins A—Q,Lindenane-Related Sesquiterpenoid Dimers from Chloranthus japonicus and Their Biological Activities
《Chinese Journal of Chemistry》2024年第11期1247-1259,共13页Wei-Jiao Feng Yue Gu Pei-Zhi Huang Hong-Ying Yang Rui Zhang Yi-Lin He Ting-Hong Lv Ya Li Kun Gao 
supported by the National Natural Science Foundation of China(Nos.22177044 and 22077058);The computational resources of this work were supported by the Supercomputing Center of Lanzhou University(China).
Seventeen undescribed lindenane-related sesquiterpenoid dimers,chlorajaponins A—Q(1—17),and 13 reported analogs(18—30)were isolated from Chloranthus japonicus Sieb.Compound 1 possesses an unprecedented 3/5/7/5/5/6/...
关键词：Chloranthus japonicus Lindenane-type sesquiterpenoid dimers Lipid-lowering activity Anti-inflammatory activity NMR spectroscopy Natural products X-ray diffraction 
A novel mouse model of familial combined hyperlipidemia and atherosclerosis
《Acta Pharmacologica Sinica》2024年第6期1316-1320,共5页Mei-jie Chen Yi-tong Xu Lu Sun Zhi-hua Wang Peter J.Little Li Wang Xun-de Xian Jian-ping Weng Suo-wen Xu 
supported by grants from the National Key R&D Program of China(Grant No.2021YFC2500500);the National Natural Science Foundation of China(Grant No.82370444,82070464,82003741,82270479,82070460);the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB38010100);supported by the Program for Innovative Research Team of The First Affiliated Hospital of USTC(CXGG02);Anhui Provincial Key Research and Development Program(Grant No.202104j07020051);Anhui Provincial Natural Science Foundation(Grant No.2208085J08).
Within the context of residual cardiovascular risk in post-statin era,emerging evidence from epidemiologic and human genetic studies have demonstrated that triglyceride(TG)-rich lipoproteins and their remnants are cau...
关键词：familial combined hyperlipidemia ApoC3 mouse model LIPID-LOWERING ATHEROSCLEROSIS 
Evaluation of the intracellular lipid-lowering effect of polyphenols extract from highland barley in HepG2 cells被引量：4
《Food Science and Human Wellness》2024年第1期454-461,共8页Yijun Yao Zhifang Li Bowen Qin Xingrong Ju Lifeng Wang 
financially supported by the National Key Research and Development Program of China(2021YFD2100904);the National Natural Science Foundation of China(31871729,32172147);the Modern Agriculture key Project of Jiangsu Province of China(BE2022317);the Modern Agricultural Industrial Technology System Construction Project of Jiangsu Province of China(JATS[2021]522);a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)。
Active ingredients from highland barley have received considerable attention as natural products for developing treatments and dietary supplements against obesity.In practical application,the research of food combinat...
关键词：Highland barley Polyphenols extract Lipid-lowering effect HepG2 cells 
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