ACTIVATORS

作品数：57被引量：221H指数：7
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Selective oxidation of emerging organic contaminants in heterogeneous Fenton-like systems
《Nano Research》2024年第11期9300-9325,共26页Sheng Wang Yuxin Lu Shangkun Pei Xiang Li Bo Wang 
financially supported by the National Natural Science Foundation of China(Nos.21625102,21971017,and 21906007);the National Key Research and Development Program of China(No.2020YFB1506300);the Beijing Institute of Technology Research Fund Program.
Heterogeneous Fenton-like reaction shows great potential for eliminating organic substances (e.g. emerging organic contaminants (EOCs)) in water, which has been widely explored in recent decades. However, the catalyti...
关键词：emerging organic contaminants heterogeneous advanced oxidation process heterogeneous activators SELECTIVITY 
Metabolites isolated from Penicillium HDS-Z-1E, an endophytic fungal strain isolated from Taxus cuspidata and their activation effect of catalase被引量：1
《Chinese Herbal Medicines》2024年第2期227-230,共4页Chuan Tang Rui Gao Xiaoyuan Tang Yu Zhang Weixing Feng Baomin Feng Xuan Lu 
supported by Excellent Youth Team for Scientific Research,Innovation and Entre-preneurship of Dalian University(No.XQN202004)。
Objective:To study the compounds isolated from Penicillium HDS-Z-1E,an endophytic fungal strain isolated from Taxus cuspidata and their activation effect of catalase(CAT).Methods:The chemical constituents were isolate...
关键词：catalase activators 5 6-dihydro-2-oxo-2H-pyran-4-carboxylic molecular simulation PENICILLIUM Taxus cuspidata Sieb.et Zucc 
Activated Carbon from Nipa Palm Fronds(Nypa fruticans)with H_(3)PO_(4) and KOH Activators as Fe Adsorbers
《Journal of Renewable Materials》2024年第2期203-214,共12页Ninis Hadi Haryanti Eka Suarso Tetti N.Manik Suryajaya Nurlita Sari Darminto 
Nipa palm is one of the non-wood plants rich in lignocellulosic content.In this study,palm fronds were converted into activated carbon,and their physical,chemical,and morphological properties were characterized.The re...
关键词：Adsorption LIGNOCELLULOSIC reduction of Fe sintering volatile content 
A high-throughput Gaussia luciferase reporter assay for screening potential gasdermin E activators against pancreatic cancer
《Acta Pharmaceutica Sinica B》2023年第10期4253-4272,共20页Yang Liu Xiaowei Zhang Ping Zhang Tingting He Weitao Zhang Dingyuan Ma Ping Li Jun Chen 
financially supported by the National Natural Science Foundation of China(No.82174100);the National Key R&D Program of China(No.2022YFC3501601)。
It is discovered that activated caspase-3 tends to induce apoptosis in gasdermin E(GSDME)-deficient cells,but pyroptosis in GSDME-sufficient cells.The high GSDME expression and apoptosis resistance of pancreatic ducta...
关键词：PYROPTOSIS Caspase-3 Gasdermin E Pancreatic ductal adenocarcinoma hGLuc-hGSDME-PCA High-throughput screening PONATINIB PERIFOSINE 
Novel thieno[2,3-b]quinoline-procaine hybrid molecules:A new class of allosteric SHP-1 activators evolved from PTP1B inhibitors
《Chinese Chemical Letters》2023年第8期213-218,共6页Lei Xu Xuyang Mu Minmin Liu Zhijia Wang Chao Shen Qianwen Mu Bo Feng Yechun Xu Tingjun Hou Lixin Gao Haini Jiang Jia Li Yubo Zhou Wenlong Wang 
supported by National Natural Science Foundation of China(Nos.81773779,21772068 and 22277043);National Science&Technology Major Project“Key New Drug Creation and Manufacturing Program”,China(No.2018ZX09711002-007-1);Natural Science Foundation of Jiangsu Province(No.BK20190608);Postgraduate Research&Practice Innovation Program of Jiangsu Province(No.KYCX22_2330).
Small molecule activators could equally provide powerful tools as inhibitors do for interrogating cellular signal transduction.However,targeted protein activation is chemically challenging.Developing activators agains...
关键词：Activator PTPs Inhibitor Thieno[2 3-b]quinoline derivatives Diffuse large B-cell lymphoma 
Brasenia-inspired hydrogel with sustained and sequential release of BMP and WNT activators for improved bone regeneration被引量：1
《Chinese Chemical Letters》2023年第7期162-168,共7页Xinqing Hao Xuewei Zhang Yue Hu Chunxia Ren Cangwei Liu Lu Wang Yijun Zhou Shuangshuang Wang Huanyu Luo Guangxing Yan Xiao Wang Xiaomeng Wang Feilong Ren Ce Shi, Wenlong Song Hongchen Sun 
supported by the National Natural Science Foundation of China (Nos. 81970903 and 81920108012);Fundamental Research Funds for the Central Universities,Jilin Provincial Science & Technology Department (No. 20200201527JC);Jilin Department of Health (No. 2019Q013);Department of Finance of Jilin Province (No. JCSZ2019378-6)。
Although bone morphogenetic protein(BMP) and WNT signaling play pivotal roles in bone development,homeostasis, and regeneration, the applications of proteins to stimulate corresponding signaling pathways showed limite...
关键词：Bone regeneration FK506 BIO Heterogeneous hydrogels Osteogenic differentiation 
Mechanism and design of allosteric activators of SIRT1
《Protein & Cell》2023年第5期387-392,共6页Fei Liu Ningning Pang Rui-Ming Xu Na Yang 
the Chinese Ministry of Science and Technology,Natural Science Foundation of China(Grant Nos.2018YFA0107004,2019YFA0508900,91853204,31870737,32170549 and 22103040);the National Postdoctoral Program for Innovative Talents(BX20180149);Haihe Laboratory of Cell Ecosystem Innovation Fund(HH22KYZX0021)and the State Key Laboratory of Medicinal Chemical Biology.
Dear Editor,The sirtuin family Nicotinamide adenine dinucleotide-dependent deacetylases have important roles in many biological processes(Milne and Denu,2008).SIRT1 is a mammalian homolog of yeast Sir2,which is the fo...
关键词：SIRT1 PGC1α 
Combined metabolic activators improve cognitive functions in Alzheimer’s disease patients:a randomised,double-blinded,placebo-controlled phase-II trial被引量：1
《Translational Neurodegeneration》2023年第1期849-871,共23页Burak Yulug Ozlem Altay Xiangyu Li Lutfu Hanoglu Seyda Cankaya Simon Lam Halil Aziz Velioglu Hong Yang Ebru Coskun Ezgi Idil Rahim Nogaylar Ahmet Ozsimsek Cemil Bayram Ismail Bolat Sena Oner Ozlem Ozdemir Tozlu Mehmet Enes Arslan Ahmet Hacimuftuoglu Serkan Yildirim Muhammad Arif Saeed Shoaie Cheng Zhang Jens Nielsen Hasan Turkez Jan Borén Mathias Uhlén Adil Mardinoglu 
funding provided by Royal Institute of Technology.This work was financially supported by ScandiBio Therapeutics and Knut and Alice Wallenberg Foundation(72110).
Background Alzheimer’s disease(AD)is associated with metabolic abnormalities linked to critical elements of neurodegeneration.We recently administered combined metabolic activators(CMA)to the AD rat model and observe...
关键词：Alzheimer’s disease Combined metabolic activators Multi-omics Systems biology Systems medicine 
Chemistry-led investigations into the mode of action of NAMPT activators,resulting in the discovery of non-pyridyl class NAMPT activators被引量：1
《Acta Pharmaceutica Sinica B》2023年第2期709-721,共13页Siyuan Tang Miguel Garzon Sanz Oliver Smith Andreas Krämer Daniel Egbase Paul W.Caton Stefan Knapp Sam Butterworth 
funded by the China Sponsorship Council(No.201709110169);support by the SGC,a registered charity(number 1097737)that receives funds from AbbVie,Bayer Pharma AG,Boehringer Ingelheim,Canada Foundation for Innovation,Eshelman Institute for Innovation,Genome Canada,Innovative Medicines Initiative(EU/EFPIA),Janssen,Merck KGaA Darmstadt Germany,MSD,Novartis Pharma AG,Ontario Ministry of Economic Development and Innovation,Pfizer,S?o Paulo Research Foundation-FAPESP and Takeda;supported by the Frankfurt Cancer Institute(FCI);the DKTK translational cancer network;financial support by the European Union Horizon 2020 research and innovation program under grant agreement number 730872,project CALIPSOplus。
The cofactor nicotinamide adenine dinucleotide(NAD+)plays a key role in a wide range of physiological processes and maintaining or enhancing NAD+levels is an established approach to enhancing healthy aging.Recently,se...
关键词：Nicotinamide phosphoribosyl transferase activator Healthy aging Drug discovery BIOISOSTERES Medicinal chemistry 
Chemical basis of pregnane X receptor activators in the herbal supplement Gancao (licorice)被引量：1
《Liver Research》2022年第4期251-257,共7页Anqi Cheng Saifei Lei Junjie Zhu Jie Lu Mary F.Paine Wen Xie Xiaochao Ma 
This work was supported by the USA National Center for Com-plementary and Integrative Health Grant R21AT011088(to X.Ma);in part by Grant U54AT008909(to M.F.Paine);in part by the USA National Institute of Allergy and Infectious Diseases Grant R01AI131983(to X.Ma);National Institute of Diabetes and Digestive and Kidney Diseases Grant R01DK126875(to X.Ma).
Background and aims:The herbal supplement Gancao,also known as licorice,belongs to the genus Glycyrrhiza and has been used worldwide for its hepatoprotective effect.Recent studies have raised concerns about potential ...
关键词：GANCAO LICORICE GLABRIDIN Pregnane X receptor(PXR) Cytochrome P4503A4(CYP3A4) Herb-drug interactions 
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