INTERACTOMICS

作品数:6被引量:3H指数:1
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相关机构:浙江清华长三角研究院更多>>
相关期刊:《Cellular & Molecular Immunology》《National Science Open》《Crop Design》《World Journal of Biological Chemistry》更多>>
相关基金:国家自然科学基金更多>>
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Comparative interactomics build the bridges from micromolecules to biological behaviour and morphology
《Crop Design》2024年第4期82-86,共5页Jinwen Chen 
Behaviour,morphology and responses to stimuli in biological systems are determined by the genetic information of different types of biomolecules and the interactions between them.Comparative interactomics,the discipli...
关键词:Interactomes Comparative interactomics Interaction networks Different types of biomolecules Review 
Single-cell protein-DNA interactomics and multiomics tools for deciphering genome regulation
《National Science Open》2023年第3期64-82,共19页Haiqing Xiong Runyu Wang Aibin He 
supported by the National Key Research and Development Program of China(2021YFA1100101 and 2017YFA0103402);the National Natural Science Foundation of China(32025015 and 31771607);the Peking-Tsinghua Center for Life Sciences.
The emergence of single-cell genomic and transcriptomic sequencing accelerates the development of single-cell epigenomic technologies,providing an unprecedented opportunity for decoding cell fate decisions largely enc...
关键词:single-cell protein-DNA interaction single-cell multiomics single-cell epigenomics epigenome genome regulation 
Capturing the hierarchically assorted modules of protein–protein interactions in the organized nucleome
《Molecular Plant》2023年第5期930-961,共32页Shuaijian Dai Shichang Liu Chen Zhou Fengchao Yu Guang Zhu Wenhao Zhang Haiteng Deng Al Burlingame Weichuan Yu Tingliang Wang Ning Li 
supported by grants 31370315,31570187,31870231,and 32070205 from the National Science Foundation of China;16102422,16103621,16101114,16103817,16103615,16100318,16101819,16101920,16306919,AOE/M-403-16,R4012-18,and C6021-19EF from the RGC of Hong Kong;ITS/480/18FP and MHP/033/20 from the Innovation and Technology Commission(ITC)of Hong Kong;the Hetao Shenzhen-Hong Kong Science and Technology Innovation Cooperation Zone project(HZQB-KCZYB-2020083);internal funding support from HKUST.
Nuclear proteins are major constituents and key regulators of nucleome topological organization and manipulators of nuclear events.To decipher the global connectivity of nuclear proteins and the hierarchically organiz...
关键词:nucleome 4C interactomics in vivo qXL-MS biomolecular modulomics CHAMPION 4D biomolecular modulomes 
Opposing regulatory functions of the TIM3 (HAVCR2) signalosome in primary effector T cells as revealed by quantitative interactomics
《Cellular & Molecular Immunology》2021年第6期1581-1583,共3页Yunhao Zhai Javier Celis-Gutierrez Guillaume Voisinne Daiki Mori Laura Girard Odile Burlet-Schiltz Anne Gonzalez de Peredo Romain Roncagalli Bernard Malissen 
supported by CNRS,INSERM,the European Research Council(ERC)under the European Union's Horizon 2020 research and innovation program(Grant agreement n°787300(BASILIC)to B.M.),ANR(SUPERBASILIC Project to B.M.),Plan Cancer 2015-Projet Cl 5091 AS(to B.M.),the MSDAvenir Fund(to B.M.),the Investissement d'Avenir program PHENOMIN(ANR-10-INBS-07,to B.M.),the ProFi(ANR-10-INBS-08 to O.B.-S.),and fellowships from DC Biol Labex(ANR-11-LABEX-0043,grant ANR-10-IDEX-0001-02 PSL,J.C.-G.),the China Scholarship Council(YZ.),the ANR(YZ.),and MSDAvenir(D.M.).
Deciphering how T-cell antigen receptor signals are modulated by coinhibitors is a fundamental goal in immunology and of considerable clinical interest because blocking coinhibitory signals via therapeutic antibodies ...
关键词:TIM3 EXPRESSING devoted 
Fasciculation and elongation zeta proteins 1 and 2: From structural flexibility to functional diversity
《World Journal of Biological Chemistry》2019年第2期28-43,共16页Mariana Bertini Teixeira Marcos Rodrigo Alborghetti J?rg Kobarg 
Fasciculation and elongation zeta/zygin(FEZ) proteins are a family of hub proteins and share many characteristics like high connectivity in interaction networks, they are involved in several cellular processes, evolve...
关键词:Hub Intrinsically DISORDERED FEZ PROTEIN-PROTEIN interaction Neuronal development RETINOIC acid signaling INTERACTOMICS 
“Stop Ne(c)king around”: How interactomics contributes to functionally characterize Nek family kinases被引量:3
《World Journal of Biological Chemistry》2014年第2期141-160,共20页Gabriela Vaz Meirelles Arina Marina Perez Edmárcia Elisa de Souza Ferna Luisa Basei Priscila Ferreira Papa Talita Diniz Melo Hanchuk Vanessa Bomfim Cardoso Jrg Kobarg 
Supported by Fundao de AmparoàPesquisa do Estado S o Paulo(FAPESP,Grant No.2010/51730-0);Conselho Nacional de Pesquisa e Desenvolvimento(CNPq);Centro Nacional de Pesquisa em Energia e Materiais(CNPEM)
Aside from Polo and Aurora, a third but less studied kinase family involved in mitosis regulation is the never in mitosis-gene A(NIMA)-related kinases(Neks). The founding member of this family is the sole member NIMA ...
关键词:Cell cycle MITOSIS DNA damage response Protein interactions KINASES 
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