Behaviour,morphology and responses to stimuli in biological systems are determined by the genetic information of different types of biomolecules and the interactions between them.Comparative interactomics,the discipli...
supported by the National Key Research and Development Program of China(2021YFA1100101 and 2017YFA0103402);the National Natural Science Foundation of China(32025015 and 31771607);the Peking-Tsinghua Center for Life Sciences.
The emergence of single-cell genomic and transcriptomic sequencing accelerates the development of single-cell epigenomic technologies,providing an unprecedented opportunity for decoding cell fate decisions largely enc...
supported by grants 31370315,31570187,31870231,and 32070205 from the National Science Foundation of China;16102422,16103621,16101114,16103817,16103615,16100318,16101819,16101920,16306919,AOE/M-403-16,R4012-18,and C6021-19EF from the RGC of Hong Kong;ITS/480/18FP and MHP/033/20 from the Innovation and Technology Commission(ITC)of Hong Kong;the Hetao Shenzhen-Hong Kong Science and Technology Innovation Cooperation Zone project(HZQB-KCZYB-2020083);internal funding support from HKUST.
Nuclear proteins are major constituents and key regulators of nucleome topological organization and manipulators of nuclear events.To decipher the global connectivity of nuclear proteins and the hierarchically organiz...
supported by CNRS,INSERM,the European Research Council(ERC)under the European Union's Horizon 2020 research and innovation program(Grant agreement n°787300(BASILIC)to B.M.),ANR(SUPERBASILIC Project to B.M.),Plan Cancer 2015-Projet Cl 5091 AS(to B.M.),the MSDAvenir Fund(to B.M.),the Investissement d'Avenir program PHENOMIN(ANR-10-INBS-07,to B.M.),the ProFi(ANR-10-INBS-08 to O.B.-S.),and fellowships from DC Biol Labex(ANR-11-LABEX-0043,grant ANR-10-IDEX-0001-02 PSL,J.C.-G.),the China Scholarship Council(YZ.),the ANR(YZ.),and MSDAvenir(D.M.).
Deciphering how T-cell antigen receptor signals are modulated by coinhibitors is a fundamental goal in immunology and of considerable clinical interest because blocking coinhibitory signals via therapeutic antibodies ...
Fasciculation and elongation zeta/zygin(FEZ) proteins are a family of hub proteins and share many characteristics like high connectivity in interaction networks, they are involved in several cellular processes, evolve...
Supported by Fundao de AmparoàPesquisa do Estado S o Paulo(FAPESP,Grant No.2010/51730-0);Conselho Nacional de Pesquisa e Desenvolvimento(CNPq);Centro Nacional de Pesquisa em Energia e Materiais(CNPEM)
Aside from Polo and Aurora, a third but less studied kinase family involved in mitosis regulation is the never in mitosis-gene A(NIMA)-related kinases(Neks). The founding member of this family is the sole member NIMA ...