URINE

作品数：524被引量：923H指数：14
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Regional Differences of the Urinary Proteomes in Healthy Chinese Individuals被引量：2
《Chinese Medical Sciences Journal》2019年第3期157-167,共11页吴建强 秦伟伟 潘利 王小蓉 张彪 单广良 高友鹤 
supported by the Key Basic Research Program of the Ministry of Science and Technology of China(No.2013FY114100);the National Key Research and Development Program of China(No.2018YFC0910202,2016YFC1306300);the Beijing Natural Science Foundation(No.7172076);the Beijing Cooperative Construction Project(No.110651103);Beijing Normal University(No.11100704);Peking Union Medical College Hospital(2016-2.27)
Objective Urine is a promising biomarker source for clinical proteomics studies.Regional physiological differences are common in multi-center clinical studies.In this study,we investigate whether significant differenc...
关键词：URINE PROTEOMICS BIOBANK biomarkers regional differences 
Early urinary candidate biomarker discovery in a rat thioacetamide-induced liver fibrosis model被引量：3
《Science China(Life Sciences)》2018年第11期1369-1381,共13页Fanshuang Zhang Yanying Ni Yuan Yuan Wei Yin Youhe Gao 
supported by the National Key Research and Development Program of China (2016YFC1306300);the National Basic Research Program of China (2013CB530850), Beijing Natural Science Foundation (7173264, 7172076);Funds from Beijing Normal University (11100704, 10300-310421102)
Biomarker is the change associated with the disease. Blood is relatively stable because of the homeostatic mechanisms of the body. However, urine accumulates changes of the body, which makes it a better early biomarke...
关键词：URINE proteomics biomarker animal MODEL liver FIBROSIS 
Elevated urine formaldehyde in elderly patients with primary open angle glaucoma被引量：3
《International Journal of Ophthalmology(English edition)》2016年第3期411-416,共6页Ying Cui Tao Su Shao-Dan Zhang Ping Huang Ying-Ge He Ying Liu Chun Zhang Robert Ritch Rong-Qiao He 
Supported by National Basic Research Program of China(973 Program,No.2012CB911004);the National Natural Science Foundation of China(No. 81041008;No.30772376)
AIM：To investigate the risk factor of primary open angle glaucoma（POAG）,which is the leading cause of irreversible blindness worldwide.An abnormally high level of endogenous formaldehyde（FA） has recently been fou...
关键词：primary open angle glaucoma urineformaldehyde Alzheimer＇s disease 
Urinary Biomarkers of Brain Diseases被引量：10
《Genomics, Proteomics & Bioinformatics》2015年第6期345-354,共10页Manxia An Youhe Gao 
supported by the National Basic Research Program of China (Grant Nos. 2012CB517606 and 2013CB530805);the Key Basic Research Program of China (Grant No. 2013FY114100)
Biomarkers are the measurable changes associated with a physiological or pathophysio- logical process. Unlike blood, urine is not subject to homeostatic mechanisms. Therefore, greater fluctuations could occur in urine...
关键词：Brain diseases URINE PROTEOMICS Metabolomics Biomarkers 
Changes of proteins induced by anticoagulants can be more sensitively detected in urine than in plasma被引量：19
《Science China(Life Sciences)》2014年第7期649-656,共8页LI MengLin ZHAO MinDi GAO YouHe 
supported by the National Basic Research Program of China (2012CB517606,2013CB530805);Expertise-Introduction Project for Disciplinary Innovation of Universities (B08007);National Natural Science Foundation of China (31200614);Beijing Natural Science Foundation (5132028)
The most fundamental property of biomarkers is change.But changes are hard to maintain in plasma since it is strictly controlled by homeostatic mechanisms of the body.There is no homeostatic mechanism for urine.Beside...
关键词：biomarker HOMEOSTASIS URINE PLASMA PROTEOMICS 
Influence of irbesartan on the urinary excretion of cytokines in patients with chronic kidney disease被引量：2
《Chinese Medical Journal》2012年第6期1147-1152,共6页NI Jie HUANG Hai-quan LÜLin-li ZHENG Min LIU Bi-cheng 
Background The non-hemodynamic effects of angiotensin receptor blocker （ARB） in the delay of progression of chronic kidney disease （CKD） remain unclear. In this study, we investigated the influence of irbesartan o...
关键词：angiotensin receptor antagonists kidney diseases CYTOKINES protein array analysis URINE 
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