NEUTROPHILS

作品数：230被引量：934H指数：16
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相关机构：中国医学科学院北京协和医学院第二军医大学中国人民解放军第三〇二医院中国科学技术大学更多>>
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Trichomonas vaginalis induces extracellular trap release in mouse neutrophils in vitro
《Acta Biochimica et Biophysica Sinica》2021年第12期1736-1738,共3页Yuhang Gao Xin Li Nan Zhang Panpan Zhao Shan Li Lixin Tai Xinyu Li Ling Li Jianhua Li Xichen Zhang Min Sun Lili Cao Pengtao Gong 
This work was supported by the grants from the National Key Basic Research Program of China(No.2015CB150300);the Fundamental Research Funds for the Central Universities.
Trichomonas vaginalis,a zoonotic anaerobic parasite first discovered in the secretions of vaginitis patients in 1836,is mainly transmitted through sexual activities.In addition,T.vaginalis can also be transmitted thro...
关键词：INFLAMMATION vaginalis PARASITE 
PKM2 controls the degranulation of secondary and tertiary granules in neutrophils by phosphorylating SNAP-23
《Cellular & Molecular Immunology》2021年第8期2048-2050,共3页Xinlei Sun Dong Wang Yan Wang Lei Ye Fujie Shi Shuang Qu Hongwei Liang Ke Zen 
This work was supported by grants from the Ministry of Science and Technology of China(2018YFA0507100);the National Natural Science Foundation of China(31670917,31770981,32000634,and 81803626);the Natural Science Foundation of Jiangsu Province(BK20180556);the fellowship of China Postdoctoral Science Foundation(2018M630642).
Polymorphonuclear neutrophils(PMNs)possess multiple distinct types of cytoplasmic granules:secondary granules,tertiary granules,and azurophil granules[1].It has been suggested that PMN degranulation is controlled by e...
关键词：PKM2 NEUTROPHILS TERTIARY 
Basic fibroblast growth factor protects against influenza A virus-induced acute lung injury by recruiting neutrophils被引量：3
《Journal of Molecular Cell Biology》2018年第6期573-585,共13页Keyu Wang Chengcai Lai Tieling Li Cheng Wang Wei Wang Bing Ni Changqing Bai Shaogeng Zhang Lina Han Hongjing Gu Zhongpeng Zhao Yueqiang Duan Xiaolan Yang Li Xing Lingna Zhao Shanshan Zhou Min Xia Chengyu Jiang Xiliang Wang Penghui Yang 
funding from the National High Technology Research and Development Program of China (SS2015AA020924);the National Natural Science Foundation of China (81771700);the Ministry of Science and Technology of China (2013ZXI0004003 and SS2012AA020905);the National Major Research and Development Program (2016YFA0502203 and 2017YFC1200800);P.Y.was supported by the Beijing Nova Program (Z141107001814054).
Influenza virus (IAV)infection is a major cause of severe respiratory illness that affects almost every country in the world.IAV infections result in respiratory illness and even acute lung injury and death,but the un...
关键词：influenza H1N1 virus recombinant FGF2 protein neutrophil recruitment FGFR2-PI3K-AKT-NFκB signaling therapeutic target 
Characterization and biological significance of IL-23-induced neutrophil polarization被引量：4
《Cellular & Molecular Immunology》2018年第5期518-530,共13页Yang Li Linnan Zhu Zhulang Chu Tao Yang Hai-Xi Sun Fan Yang Wei Wang Yuzhu Hou Peng Wang Qingjie Zhao Yaling Tao Lianfeng Zhang Xiaodong Zhang Yong Zhao 
supported by grants from the National Basic Research Program of China(2014ZX10002002-001-002,YZ;2011CB710903,YZ);the National Natural Science Foundation of China for General and Key Programs(81530049,81130055,YZ);the Knowledge Innovation Program of the Chinese Academy of Sciences(XDA04020202-19,YZ);the Beijing Municipal Hospital Authority‘Yangfan Program’(ZYLX201408,XZ);the CAS/SAFEA International Partnership Program for Creative Research Teams(YZ).
Neutrophils are heterogeneous with distinct subsets,and can switch phenotypes to exert regulatory functions on immunity.We herein demonstrate that IL-23-treated neutrophils selectively produce IL-17A,IL-17F and IL-22,...
关键词：COLITIS IL-17 IL-23 INFLAMMATION NEUTROPHILS POLARIZATION 
Surface modification of PGP for a neutrophil–nanoparticle co-vehicle to enhance the anti-depressant effect of baicalein被引量：4
《Acta Pharmaceutica Sinica B》2018年第1期64-73,共10页Baoyu Chen Man Luo Jianming Liang Chun Zhang Caifang Gao Jue Wang Jianxin Wang Yongji Li Desheng Xu Lina Liu Ning Zhang Huijun Chen Jing Qin 
financial support from the National Natural Science Foundation of China (81673372, 81690263, 81361140344 and 81773911);the National Basic Research Program of China (2013CB 932502);the Opening Project of Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education (Sichuan University, Chengdu, China);the Development Project of Shanghai Peak Disciplines–Integrated Medicine (No. 20150407);the Open Project Program of Key Lab of Smart Drug Delivery (Fudan University, Shanghai, China), Ministry of Education, China
Exploiting cells as vehicles combined with nanoparticles combined with therapy has attracted increasing attention in the world recently. Red blood cells, leukocytes and stem cells have been used for tumor immunotherap...
关键词：PGP peptide NEUTROPHILS Dual-brain targeting delivery Solid lipid nanoparticle Depression BAICALEIN Olfactory bulbectomy rats 
RO-heparin Inhibits L-Selectin-mediated Neutrophils Adhesion to Vascular Endothelium Under Flow Conditions被引量：2
《Chemical Research in Chinese Universities》2006年第3期302-307,共6页CHEN Zhi-hong XU Li BA Xue-qing ZENG Xian-lu 
SupportedbytheNationalBasicResearchProgramofChina(No.2002CB513000)andtheNationalNaturalScienceFoundationofChina(Nos.30570927and30570928).
Selectins are carbohydrate-binding cell adhesion molecules that play a major role in the initiation of inflammatory responses. Accumulaed evidence has suggested that heparin＇s anti-inflammatory effects are mainly med...
关键词：RO-heparin Neutrophils adhesion L-SELECTIN Human umbilical vein endothelial cells （HUVECs） 
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