云南高校图书馆联盟文献共享服务平台- URATE

URATE: 作品数：48被引量：132H指数：7; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：徐明蒋季杰程旭光汤羽李懋更多>>; 相关机构：成都体育学院南通医学院附属医院甘肃省人民医院更多>>; 相关期刊：《Acupuncture and Herbal Medicine》《Chinese Journal of Integrative Medicine》《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划北京市自然科学基金广东省自然科学基金更多>>

Transport mechanism and structural pharmacology of human urate transporter URAT1: 《Cell Research》2024年第11期776-787,共12页Yaxin Dai Chia-Hsueh Lee; supported by National Institutes of Health grants(R01GM143282 and R01NS133147);C.-H.L.and Y.D.are supported by ALSAC.; Urate is an endogenous product of purine metabolism in the liver.High urate levels in the blood lead to gout,a very common and painful inflammatory arthritis.Excreted urate is reabsorbed in the kidney mainly by URAT1 ...; 关键词：URATE ANION mechanism

Fatty acid oxidation-induced HIF-1α activation facilitates hepatic urate synthesis through upregulating NT5C2 and XDH被引量：2: 《Life Metabolism》2024年第5期17-31,共15页Ningning Liang Xuan Yuan Lili Zhang Xia Shen Shanshan Zhong Luxiao Li Rui Li Xiaodong Xu Xin Chen Chunzhao Yin Shuyuan Guo Jing Ge Mingjiang Zhu Yongzhen Tao Shiting Chen Yongbing Qian Nicola Dalbeth Tony RMerriman Robert Terkeltaub Changgui Li Qiang Xia Huiyong Yin; funded by grants from the National Key Research and Development Program of China(2022YFC2503300 and 2018YFA0800300);the National Natural Science Foundation of China(32030053 and 32241017);the startup fund from City University of Hong Kong(9380154);the RGC Theme-based Research Scheme(8770011);the TBSC Project fund,and Shenzhen Medical Research Fund(B2302042);R.T.was supported by the VA Research Service(I01 BX005927)and NIH(PAG007996).; Dyslipidemia affects approximately half of all people with gout,and prior Mendelian randomization analysis suggested a causal role for elevated triglycerides in hyperuricemia(HU),but the underlying mechanisms remain e...; 关键词：DYSLIPIDEMIA HYPERURICEMIA PURINE HYPOXANTHINE metabolic flux

Development of a radiomics model to discriminate ammonium urate stones from uric acid stones in vivo:A remedy for the diagnostic pitfall of dual-energy computed tomography: 《Chinese Medical Journal》2024年第9期1095-1104,共10页Junjiong Zheng Jie Zhang Jinhua Cai Yuhui Yao Sihong Lu Zhuo Wu Zhaoxi Cai Aierken Tuerxun Jesur Batur Jian Huang Jianqiu Kong Tianxin Lin; supported by the China Postdoctoral Science Foundation(Nos.2021TQ0387,2022M713625,and 2021M703709);the National Natural Science Foundation of China(Nos.82203188 and 81825016);Guangdong Provincial Clinical Research Center for Urological Diseases(No.2020B1111170006);the Guangdong Basic and Applied Basic Research Foundation(No.2020A1515111119); Background:Dual-energy computed tomography(DECT)is purported to accurately distinguish uric acid stones from non-uric acid stones.However,whether DECT can accurately discriminate ammonium urate stones from uric acid s...; 关键词：Ammonium urate Dual-energy scanned projection radiography Radiomics Uric acid UROLITHIASIS

Serum urate is associated with an increased risk of inflammatory bowel disease: A bidirectional Mendelian randomization study: 《World Journal of Clinical Cases》2024年第5期891-902,共12页Song Zhang Xue Fang Le Kang Xiang-Yu Sui Miao Liu Yu-Jia Luo Shuo Fu Zhao-Shen Li Sheng-BingZhao Yu Bai; Supported by National Natural Science Foundation of China,No.82170567,No.81873546,No.82170568,and No.82300627;Program of Shanghai Academic/Technology Research Leader,No.22XD1425000;The"Shu Guang"project of Shanghai Municipal Education Commission and Shanghai Education Development Foundation,No.19SG30,China;Deep Blue Project of Naval Medical University(Pilot Talent Plan);The Chenguang Program of Shanghai Education Development Foundation and Shanghai Municipal Education Commission,No.22CGA42;The Shanghai Sailing Program,No.23YF1458600;and Shanghai Natural Science Foundation,No.23ZR1478700.; BACKGROUND Previous studies have indicated bidirectional associations between urate levels and inflammatory bowel disease(IBD),including ulcerative colitis(UC)and Crohn’s disease(CD).However,it remains unclear whethe...; 关键词：Inflammatory bowel disease Urate levels ANTIOXIDANT Mendelian randomization Single nucleotide polymorphism

Antihyperuricemic and Nephroprotective Effects of the Total Flavonoids from Carya cathayensis Leaves(CCTF)in Potassium Oxonate/hypoxanthine-induced Hyperuricemic Mice: 《Clinical Complementary Medicine and Pharmacology》2023年第4期91-98,共8页Jiahui Hao Fangmei Zhou; The Zhejiang Traditional Chinese Medicine Administration(CN)(Project No.2023ZF012).; Background:Abnormally high level of uric acid in the blood,defined as hyperuricemia(HUA),increases the chance of developing various disorders,such as gout,hypertension,and diabetes.There is a critical need to create s...; 关键词：Leaves of Carya cathayensis HYPERURICEMIA Urate transporters Total flavonoids

Tailoring Polyimide Chain by Melamine-Cyanurate Supramolecule via a Molecular Welding Strategy Achieving Superior Thermal Conductivity: 《Journal of Thermal Science》2023年第4期1558-1568,共11页ZHAO Chenggong LI Yifan MA Manping KAN Ankang XIE Huaqing YU Wei; funding from the Shanghai Sailing Program (21YF1414200); Polyimide(PI)films are widely used in printed circuit boards,electronic packaging,interlayer media,display panels,and other fields.Improving the thermal conductivity of PI film is of great significance to promote effe...; 关键词：polyimide film molecular chain arrangement intermolecular interaction heat dissipation

New and emerging therapies in gout: 《Rheumatology & Autoimmunity》2023年第2期70-77,共8页Reeta James Binoy J.Paul; Gout is a disease that has been pestering humankind for centuries.Hence,gout therapeutics has always been a field of ongoing research.Beginning from colchicine,which was the first drug to come into use,to the latest i...; 关键词：caspase inhibitor GOUT inflammasome inhibitor urate transporter-1 inhibition

Galangin probably ameliorates hyperuricemia by inhibiting urate acid transport 1 (URAT1): Homology modeling and mechanism exploration: 《Journal of Polyphenols》2022年第1期55-63,共9页Aijinxiu Ma Fuqi Wang Xu Zhao; This work was supported by Young and Middle Aged Teachers’Career Development Support Project of Shenyang Pharmaceutical University(ZQN2019005).; Urate acid transporter 1(URAT1)is the main transporter of uric acid reabsorption,which closely related to the pathogenesis of hyperuricemia.Screening URAT1 inhibitors and studying their possible metabolic processes is...; 关键词：plant polyphenols GALANGIN URAT1 HYPERURICEMIA homology modeling

Hearing loss due to urate deposition in the middle ear:A case report and literature review: 《Journal of Otology》2022年第1期50-53,共4页M.Hoste M.Cabri-Wiltzer S.Hassid J.-C.Degols J.Vilain; Gout is the most common cause of monoarthritis in men occurring classically in the great toe and the knee.Extra-articular gout manifestations are rare.Only a few cases of head and neck urate crystals deposits have bee...; 关键词：Hearing loss Urate deposit GOUT Middle ear OTOSCOPY

CDER167,a dual inhibitor of URAT1 and GLUT9,is a novel and potent uricosuric candidate for the treatment of hyperuricemia被引量：9: 《Acta Pharmacologica Sinica》2022年第1期121-132,共12页Ze-an Zhao Yu Jiang Yan-yu Chen Ting Wu Qun-sheng Lan Yong-mei Li Lu Li Yang Yang Cui-ting Lin Ying Cao Ping-zheng Zhou Jia-yin Guo Yuan-xin Tian Jian-xin Pang; This work was supported by the National Natural Science Foundation of China(81773794 and 81974507)and the Natural Science Foundation of Guangdong Province(2018A0303130088).; Urate transporter 1(URAT1)and glucose transporter 9(GLUT9)are important targets for the development of uric acid-lowering drugs.We previously showed that the flexible linkers of URAT1 inhibitors could enhance their po...; 关键词：GOUT HYPERURICEMIA uric acid-lowering drugs RDEA3710 CDER167 urate transporter 1(URAT1) glucose transporter 9(GLUT9)

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