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Researchers Reveal New Epigenetic Suppressors and Potential Therapeutic Modality for Lung Cancer: 《Bulletin of the Chinese Academy of Sciences》2022年第1期56-57,共2页XU Guoliang JI Hongbin; Genetics and epigenetics are inextricably linked in the pathogenesis of cancer,among which epigenetic aberrations are frequently observed and also known to cooperate with genetic alterations to drive malignant transfo...; 关键词：alterations Lung Cancer

Identification of reference genes provides functional insights into meiotic recombination suppressors in Gerbera hybrida被引量：2: 《Horticultural Plant Journal》2022年第1期123-132,共10页Fan Li Ying Cheng Lulin Ma Shenchong Li Jihua Wang; funded by Yunnan Fundamental Research Projects(Grant No.2019FD030);Major Science and Technology Project of Yunnan Provincial Department of Science and Technology(Grant Nos.2019ZG006,202102AE090052);Ten-thousand Talents Program of Yunnan Province–Yunling Scholar of Industrial Technology Leading Talent Project(Grant No.Yun Fagai Renshi[2018]No.212)。; Gerbera Hybrida is one of the important cut flowers across the world.The novel traits are the primarily market requirements and the breeding targets,mainly determined by the degree of genetic variation after hybridiza...; 关键词：erbera hybrida Reference gene Gene expression Meiotic recombination suppressor

Direct acetylation of a conserved threonine of RIN4 by the bacterial effector HopZ5 or AvrBsT activates RPM1-dependent immunity in Arabidopsis被引量：5: 《Molecular Plant》2021年第11期1951-1960,共10页Arabidopsis Sera Choi Maxim Prokchorchik Hyeonjung Lee Ravi Gupta Yoonyoung Lee Eui-Hwan Chung Buhyeon Cho Min-Sung Kim Sun Tae Kim Kee Hoon Sohn; This research was supported by Basic Science Research Programs through the National Research Foundation of Korea(NRF)funded by the Ministry of Education(NRF-2019R1I1A1A01060108);Korean government(MSIT)(NRF-2018R1A5A1023599 and NRF-2019R1A2C2084705)。; Plant pathogenic bacteria deliver effectors into plant cells to suppress immunity and promote pathogen survival;however, these effectors can be recognised by plant disease resistance (R) proteins to activate innate im...; 关键词：Acetyltransferase effectors Effector-triggered immunity Immunity suppressors NLR Plant deacetylase Plant immunity

AU-rich element-binding proteins in colorectal cancer被引量：9: 《World Journal of Gastrointestinal Oncology》2019年第2期71-90,共20页Noémie Legrand Dan A Dixon Cyril Sobolewski; Supported by the National Institutes of Health/National Cancer Institute Cancer Center Support grant P30 CA168524(DD);supported by a grant of the Geneva Cancer League(Grant no.1711); Trans-acting factors controlling mRNA fate are critical for the post-transcriptional regulation of inflammation-related genes, as well as for oncogene and tumor suppressor expression in human cancers. Among them, a gr...; 关键词：COLORECTAL cancer Adenylate-Uridylate-rich element-binding proteins ONCOGENES Tumor SUPPRESSORS POST-TRANSCRIPTIONAL regulation

Presynaptic inhibition of nociceptive neurotransmission by somatosensory neuron-secreted suppressors被引量：3: 《Science China(Life Sciences)》2017年第9期1013-1018,共6页Kaicheng Li Bing Cai Changlin Li Xu Zhang; supported by National Natural Science Foundation of China(31630033,31130066,31671094,81300961);Chinese Academy of Sciences(XDB02010000,QYZDY-SSW-SMC007);Shanghai Science and Technology Committee(16JC1420500); Noxious stimuli cause pain by activating cutaneous nociceptors.The Aδ-and C-fibers of dorsal root ganglion(DRG) neurons convey the nociceptive signals to the laminae Ⅰ—Ⅱ of spinal cord.In the dorsal horn of spinal...; 关键词：pain sensation SYNAPSE dorsal root ganglion spinal cord

DELLA Proteins Promote Anthocyanin Biosynthesis via Sequestering MYBL2 and JAZ Suppressors of the MYB/bHLH/WD40 Complex in Arabidopsis thaliana被引量：53: 《Molecular Plant》2016年第5期711-721,共11页Ye Xie Huijuan Tan Zhaoxue Ma Jirong Huang; Anthocyanin accumulation is recognized as a visible biomarker of plants that have suffered from environmental stresses. However, the molecular mechanisms underlying stress-induced anthocyanin biosynthesis remain uncle...; 关键词：DELLA MYBL2 JAZ anthocyanin biosynthesis abiotic stresses

Oncogenic role of p21 in hepatocarcinogenesis suggests a new treatment strategy被引量：7: 《World Journal of Gastroenterology》2015年第42期12150-12156,共7页Shogo Ohkoshi Masahiko Yano Yasunobu Matsuda; Supported by Grant-in-Aid for Scientific Research(C)(22590722 for Ohkoshi S)from the Japan Society for the promotion of Science(JSPS); A well-known tumor suppressor, p21, acts parado-xically by promoting tumor growth in some cellular conditions. These conflicting functions have been demonstrated in association with the HBx gene and in hepatocarcinoge...; 关键词：P21 Tumor SUPPRESSORS ONCOGENE SUBCELLULAR localiz

Fast-Suppressor Screening for New Components in Protein Trafficking,Organelle Biogenesis and Silencing Pathway in Arabidopsis thaliana Using DEX-Inducible FREE1-RNAi Plants被引量：3: 《Journal of Genetics and Genomics》2015年第6期319-330,共12页Qiong Zhao Caiji Gao PoShing Lee Lin Liu Shaofang Li Tangjin Hu Jinbo Shen Shuying Pan Hao Ye Yunru Chen Wenhan Cao Yong Cui Peng Zeng Sheng Yu Yangbin Gao Liang Chen Beixin Mo Xin Liu Shi Xiao Yunde Zhao Silin Zhong Xuemei Chen Liwen Jiang; supported by grants from the NIH GM114660 to Y.Zhao;the Research Grants Council of Hong Kong (CUHK466011,465112,466613,CUHK2/CRF/11G,C401114R and Ao E/M-05/12);NSFC/RGC (N_CUHK406/12);NSFC (31270226 and 31470294);Shenzhen Peacock Project (KQTD201101) to L.Jiang; Membrane trafficking is essential for plant growth and responses to external signals.The plant unique FYVE domain-containing protein FREE1 is a component of the ESCRT complex（endosomal sorting complex required for tr...; 关键词：SUPPRESSORS FREE1 Endomembrane trafficking Arabidopsis NGS

SOCS3 Expression Correlates with Severity of Inflammation in Mouse Hepatitis Virus Strain 3-induced Acute Liver Failure and HBV-ACLF被引量：9: 《Journal of Huazhong University of Science and Technology(Medical Sciences)》2014年第3期348-353,共6页李咏韩梅芳李维娜师爱超张元亚王宏艳王发席李兰吴婷丁琳陈韬严伟明罗小平宁琴; supported by the grants from the National Science Foundation of China Advanced Program(No.NSFC81171558,NSFC81271808 and NSFC81030007);Innovation Team Development Plan of the Ministry of Education of China[No.IRT1131(2011)];National Twelfth-Five Years Project in Science and Technology of China(No.2013ZX10002-003); Summary： Recently, suppressor of cytokine signaling-3 （SOCS3） has been shown to be an inducible endogenous negative regulator of Janus kinase/signal transducers and activators of transcription （JAK/STAT） pathway ...; 关键词：suppressors of cytokine signaling-3 HBV-induced acute-on-chronic liver failure mouse hepatitis virus strain 3 fulminant liver failure BALB/cJ mice

The role of XPC protein deficiency in tobacco smoke-induced DNA hypermethylation of tumor suppressor genes被引量：1: 《Open Journal of Genetics》2013年第4期285-293,共9页Gan Wang Le Wang Vanitha Bhoopalan Yue Xi Deepak K. Bhalla David Wang Xiaoxin S. Xu; DNA hypermethylation of tumor suppressor genes has been frequently observed in cancer patients, and therefore, may provide a valuable biomarker for cancer prevention and treatment. DNA hypermethylation may also provid...; 关键词：DNA HYPERMETHYLATION Tumor SUPPRESSORS XPC TOBACCO Smoke DNA Damage DNA Repair Deficiency ATR DNMT3A

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