IGURATIMOD

作品数：8被引量：13H指数：3
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相关领域：医药卫生更多>>
相关作者：张冕更多>>
相关机构：江苏省人民医院苏州大学更多>>
相关期刊：《Bone Research》《药学进展》《Acta Pharmacologica Sinica》《国外药讯》更多>>
相关基金：国家自然科学基金更多>>
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Iguratimod suppresses plasma cell differentiation and ameliorates experimental Sjögren’s syndrome in mice by promoting TEC kinase degradation
《Acta Pharmacologica Sinica》2024年第9期1926-1936,共11页Ya-qi Yang Yi-jun Liu Wen-xuan Qiao Wei Jin Shun-wei Zhu Yu-xi Yan Qiong Luo Qiang Xu 
National Natural Science Foundation of China(82230116,21937005,81773743,81973331);Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(ZYYCXTD-C-202208);Fundamental Research Funds for the Central Universities of China(0208/14380185).
Primary Sjögren’s syndrome(pSS)is a chronic inflammatory autoimmune disease with an unclear pathogenesis,and there is currently no approved drug for the treatment of this disease.Iguratimod,as a novel clinical anti-r...
关键词：Sjögren’s syndrome IGURATIMOD B cell TEC kinase protein degradation salivary gland 
Iguratimod in treatment of primary Sjögren’s syndrome concomitant with autoimmune hemolytic anemia:A case report被引量：1
《World Journal of Clinical Cases》2022年第4期1286-1290,共5页Juan Zhang Xin Wang Jing-Jing Tian Rong Zhu Rui-Xue Duo Yi-Chen Huang Hai-Li Shen 
Supported by the Lanzhou Science and Technology Plan Project,No.2018-3-48;Lanzhou Talent Innovation and Entrepreneurship Project,No.2019-RC-35;and 2019 Special Fund for Doctoral Training of Lanzhou University Second Hospital,No.YJS-BD-15.
BACKGROUND Primary Sjögren's syndrome(pSS)concomitant with autoimmune hemolytic anemia(AIHA)but without eye and mouth dryness is exceedingly rare.Iguratimod(IGU)has been widely used in the treatment of pSS.However,the...
关键词：Autoimmune hemolytic anemia IGURATIMOD Primary Sjögren’s syndrome Case report 
Iguratimod promotes transformation of mononuclear macrophages in elderly patients with rheumatoid arthritis by nuclear factor-κB pathway被引量：4
《World Journal of Clinical Cases》2021年第10期2181-2191,共11页Sha Liu Li-Ping Song Rong-Bin Li Le-Heng Feng Hui Zhu 
BACKGROUND The role of macrophages in rheumatoid arthritis(RA)and its mechanism have attracted much attention in RA pathogenesis.Macrophages accumulate in the synoviums of RA,and the proportion of M1 type pro-inflamma...
关键词：Rheumatoid arthritis IGURATIMOD MACROPHAGE Polarity Nuclear factor-κB 
Iguratimod: a valuable remedy from the Asia Pacific region for ameliorating autoimmune diseases and protecting bone physiology被引量：4
《Bone Research》2019年第4期327-337,共11页Jie Li Jun Bao Jian Zeng Aizhu Yan Chunqiu Zhao Qiang Shu 
supported by the Natural Science Foundation of Shandong Province (ZR2012HM038);the Shenzhen Science and Technology Innovation Committee Fund (JCYJ2016033117365255);the China International Medical Foundation (Simcere-Z2014-06-2-1635);the China Torch Program (2013GH021476)
Autoimmune diseases are affected by complex pathophysiology involving several cell types,cytokines,antibodies,and mimicking factors.Different drugs are used to ameliorate these autoimmune reactions,including nonsteroi...
关键词：AUTOIMMUNE DRUGS DISEASES 
Iguratimod, a Disease-Modifying Anti-Rheumatic Drug, Inhibits Osteoclastogenesis and Bone Resorption through Suppression of the Nuclear Factor of Activated T Cells Signaling Pathway
《Open Journal of Rheumatology and Autoimmune Diseases》2016年第4期106-119,共14页Jun Shiota Hidetoshi Murao Akihiko Miura Masaaki Mikami Keiichi Tanaka 
Introduction: The aim of this study was to observe an inhibition of bone resorption and osteoclastogenesis by iguratimod (IGU, T-614), a disease-modifying anti-rheumatic drug, using adjuvant-induced arthritis (AIA) ra...
关键词：Bone Resorption IGURATIMOD NFATc1 OSTEOCLAST Rheumatoid Arthritis 
Anti-rheumatic Drug Iguratimod(T-614) Alleviates Cancer-induced Bone Destruction via Down-regulating Interleukin-6 Production in a Nuclear Factor-κB-dependent Manner被引量：4
《Journal of Huazhong University of Science and Technology(Medical Sciences)》2016年第5期691-699,共9页孙越 叶达伟 张鹏 吴颖星 王邦彦 彭广 于世英 
supported by grants from the National Natural Science Foundation of China(Nos.81372852 and 81202095)
Cytokines are believed to be involved in a “vicious circle” of progressive interactions in bone metastasis. Iguratimod is a novel anti-rheumatic drug which is reported to have the capability of anti-cytokines. In th...
关键词：rheumatic T-614 Interleukin invasion regulating cytometry metastasis manner suppression destruction 
抗类风湿性关节炎药Iguratimod
《药学进展》2009年第9期429-430,共2页
关键词：IGURATIMOD IL-6拮抗剂 类风湿性关节炎 
01069 Iguratimod——有希望的类风湿性关节炎新药
《国外药讯》2005年第1期26-26,共1页李燕燕 
Iguratimod(T614，Careram)(Ⅰ)是一种新的缓解疾病的抗风湿性药物(DMARD)，它有望成为类风湿性关节炎患者的一种有效治疗药物。2004年6月在德国柏林召开的欧洲风湿性关节炎联盟(EULAR)会议上介绍的一份Ⅲ期研究表明，(Ⅰ)的疗效和安全...
关键词：IGURATIMOD 类风湿性关节炎药 新药 药理 
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