The Y-located testis-specific protein Y-encoded (TSPY) and its X-homologue TSPX originated from the same ancestral gene, but act as a proto-oncogene and a tumor suppressor gene, respectively. TSPY has specialized in m...
partially supported by a Merit-Reviewed grant from the Department of Veterans Affairs;a Peer-Reviewed Cancer Research Program grant from the Department of Defense (W81XWH-16-1-0488) to Y-FCL
Testis specific protein Y-encoded(TSPY) is a Y-located proto-oncogene predominantly expressed in normal male germ cells and various types of germ cell tumor. Significantly, TSPY is frequently expressed in somatic ca...
Male and female differ genetically by their respective sex chromosome composition, that is, XY as male and XX as female. Although both X and Y chromosomes evolved from the same ancestor pair of autosomes, the Y chromo...
supported by World Bank funded National Agricultural Innovation Project(C4/C30015)
Background: The Y chromosome in mammal is paternally inherited and harbors genes related to male fertility and spermatogenesis. The unique intra-chromosomal recombination pattern of Y chromosome and morphological dif...
supported by the grants from the Meritreviewed Research and REAP Prostate Cancer Programs of Department of Veterans Affairs,Department of Defense Prostate Cancer Research Program and National Institutes of Health to Y.-EC.L.Y.-EC.Lau is a Research Career Scientist of the Department of Veterans Affairs.We thank Dr.Yunmin Li for technical assistance
The testis specific protein Y-encoded (TSPY) is a member of TSPY/SET/NAP1 superfamily, encoded within the gonadoblastoma locus on the Y chromosome. TSPY shares a highly conserved SET/NAP-domain responsible for prote...