TSPY

作品数:8被引量:20H指数:3
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相关领域:农业科学医药卫生更多>>
相关作者:黄金明游伟蒋小兵罗晓林官久强更多>>
相关机构:山东省农业科学院四川省草原科学研究院北京大学山东省畜禽疫病防治与繁育重点实验室更多>>
相关期刊:《Journal of Animal Science and Biotechnology》《黑龙江畜牧兽医》《农业生物技术学报》《Asian Journal of Andrology》更多>>
相关基金:国家肉牛牦牛产业技术体系项目山东省农业良种工程项目山东省自然科学基金山东省科技攻关计划更多>>
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Battle of the sexes: contrasting roles of testis-specific protein Y-encoded (TSPY) and TSPX in human oncogenesis
《Asian Journal of Andrology》2019年第3期260-269,共10页Yun-Fai Chris Lau Yunmin Li Tatsuo Kido 
The Y-located testis-specific protein Y-encoded (TSPY) and its X-homologue TSPX originated from the same ancestral gene, but act as a proto-oncogene and a tumor suppressor gene, respectively. TSPY has specialized in m...
关键词:ANDROGEN receptor AR-V7 cell cycle regulation cyclin B-CDK1 ONCOGENE SEX chromosomes SEX differences TSPX TSPY tumor suppressor 
牦牛、犏牛和黄牛组织中TSPY基因表达水平研究被引量:4
《黑龙江畜牧兽医》2017年第6期232-235,298,共5页官久强 蒋小兵 杨平贵 安添午 谢荣清 赵洪文 罗晓林 
国家肉牛牦牛产业技术体系项目(CARS-38);利用高通量测序技术研究犏牛雄性不育的分子机理;金川多肋牦牛种质资源研究项目(2014NZ0094);牦牛现代产业链关键技术集成研究与产业示范项目(2012NZ0047)
为了进一步研究TSPY基因与雄性不育的关系,试验采用荧光定量和免疫组化技术对黄牛、犏牛和牦牛不同组织TSPY基因进行定量分析。结果表明:TSPY基因在睾丸组织中高表达。在睾丸组织中,犏牛、黄牛TSPY基因相对表达量均显著高于牦牛(P<0.05)...
关键词:牦牛 犏牛 黄牛 TSPY基因 基因表达 
Identification of a TSPY co-expression network associated with DNA hypomethylation and tumor gene expression in somatic cancers被引量:2
《Journal of Genetics and Genomics》2016年第10期577-585,共9页Tatsuo Kido Yun-Fai Chris Lau 
partially supported by a Merit-Reviewed grant from the Department of Veterans Affairs;a Peer-Reviewed Cancer Research Program grant from the Department of Defense (W81XWH-16-1-0488) to Y-FCL
Testis specific protein Y-encoded(TSPY) is a Y-located proto-oncogene predominantly expressed in normal male germ cells and various types of germ cell tumor. Significantly, TSPY is frequently expressed in somatic ca...
关键词:Co-expression network DNA methylation Gene expression signature Cancer subclassification Y chromosome genes TSPY Cancer/testis antigens 
Roles of the Y chromosome genes in human cancers被引量:9
《Asian Journal of Andrology》2015年第3期373-380,共8页Tatsuo Kido Yun-Fai Chris Lau 
Male and female differ genetically by their respective sex chromosome composition, that is, XY as male and XX as female. Although both X and Y chromosomes evolved from the same ancestor pair of autosomes, the Y chromo...
关键词:germ cell tumors RBMY  Y-linked somatic cancers TSPY Y chromosome 
Absolute copy number differences of Y chromosomal genes between crossbred (Bos taurus×Bos indicus) and Indicine bulls被引量:3
《Journal of Animal Science and Biotechnology》2013年第4期257-263,共7页Ayan Mukherjee Gulshan Dass Jagan Mohanarao G Moloya Gohain Biswajit Brahma Tirtha Kumar Datta Sachinandan De 
supported by World Bank funded National Agricultural Innovation Project(C4/C30015)
Background: The Y chromosome in mammal is paternally inherited and harbors genes related to male fertility and spermatogenesis. The unique intra-chromosomal recombination pattern of Y chromosome and morphological dif...
关键词:Absolute copy SRY DDX3Y usPgY TSPY CROSSBRED 
Expression of the human TSPY gene in the brains of transgenic mice suggests a potential role of this Y chromosome gene in neural functions被引量:1
《Journal of Genetics and Genomics》2011年第5期181-191,共11页Tatsuo Kido Stephanie Schubert Jrg Schmidtke Yun-Fai Chris Lau 
supported by the grants from the Meritreviewed Research and REAP Prostate Cancer Programs of Department of Veterans Affairs,Department of Defense Prostate Cancer Research Program and National Institutes of Health to Y.-EC.L.Y.-EC.Lau is a Research Career Scientist of the Department of Veterans Affairs.We thank Dr.Yunmin Li for technical assistance
The testis specific protein Y-encoded (TSPY) is a member of TSPY/SET/NAP1 superfamily, encoded within the gonadoblastoma locus on the Y chromosome. TSPY shares a highly conserved SET/NAP-domain responsible for prote...
关键词:TSPY TSPX CASK Y chromosome Neuron TESTIS 
睾丸特异蛋白Y基因(TSPY)对奶牛早期胚胎性别的鉴定被引量:2
《农业生物技术学报》2009年第3期433-438,共6页黄金明 王长法 李建斌 仲跻峰 
山东省自然科学基金项目(No.Y2007D72);山东省农业良种工程项目(No.2006LZ10-04)资助
为方便性别鉴定方法在现场应用,利用睾丸特异蛋白基因(TSPY)建立了奶牛早期胚胎的非电泳性别鉴定方法。设计并合成了TSPY雄性特异和雌、雄共有基因引物,并利用已知性别的奶牛血液DNA为模板,初步建立了性别鉴定的PCR反应体系和非电泳的...
关键词:奶牛胚胎 性别鉴定 睾丸特性蛋白Y基因(TSPY) PCR 
利用TSPY基因鉴定奶牛早期胚胎性别的研究
《家畜生态学报》2006年第3期10-12,共3页黄金明 张俊功 游伟 朱荣生 崔绪奎 
山东省科技攻关项目(031020108-1);山东省农业科学院畜牧兽医研究所青年基金项目
TSPY(testis-specific protein)是Y染色体上特异的基因。公牛Y染色体上的TSPY基因的拷贝数达200个。本研究主要探讨利用TPSY基因鉴定胚胎性别的可能性。利用TSPY特异引物,通过PCR技术扩增牛血样DNA的结果为公牛血样均为阳性,母牛为阴性...
关键词: 胚胎 PCR 性别鉴定 TSPY基因 
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