THIOSTREPTON

作品数:4被引量:0H指数:0
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相关领域:医药卫生更多>>
相关作者:汪健姜斌郭跃辉王竞袁海花更多>>
相关机构:中国科学院大学上海交通大学上海交通大学医学院附属第三人民医院重庆医科大学更多>>
相关期刊:《Cellular & Molecular Immunology》《Acta Pharmacologica Sinica》《American Journal of Molecular Biology》《现代肿瘤医学》更多>>
相关基金:上海市科学技术委员会资助项目北京市自然科学基金国家自然科学基金更多>>
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Thiostrepton alleviates experimental colitis by promoting RORγt ubiquitination and modulating dysbiosis
《Cellular & Molecular Immunology》2023年第11期1352-1366,共15页Ya Luo Cheng Liu Yuan Luo Xianglian Zhang Jing Li Changjiang Hu Shiming Yang 
This work was supported by the National Key Research and Development Program of China(2018YFA0507900);the National Natural Science Foundation of China(81802460);the Natural Science Foundation of Chongqing(CSTB2022NSCQ-MSX0184).
Thiostrepton(TST)is a natural antibiotic with pleiotropic properties.This study aimed to elucidate the therapeutic effect of TST on experimental colitis and identify its targets.The effect of TST on colon inflammation...
关键词:Thiostrepton(TST) COLITIS RORΓT IL-17A Gut microbiota 
c-FLIP promotes drug resistance in non-small-cell lung cancer cells via upregulating FoxM1 expression
《Acta Pharmacologica Sinica》2022年第11期2956-2966,共11页Wen-die Wang Yue Shang Chen Wang Jun Ni Ai-min Wang Gao-jie Li Ling Su Shu-zhen Chen 
the National Natural Science Foundation of China(81702934);CAMS Innovation Fund for Medical Sciences(CIFMS,2019-12M-1-003,2021-12M-1-030);Beijing Natural Science Foundation(7202132,7192041).
The forkhead box M1(FoxM1)protein,a transcription factor,plays critical roles in regulating tumor growth and drug resistance,while cellular FLICE-inhibitory protein(c-FLIP),an anti-apoptotic regulator,is involved in t...
关键词:non-small-cell lung cancer C-FLIP FOXM1 UBIQUITINATION THIOSTREPTON osimertinib 
Thiostrepton介导FOXM1下调对非小细胞肺癌细胞生长及其AG1478药物敏感性的影响
《现代肿瘤医学》2013年第1期38-42,共5页公小迪 袁海花 王炯轶 郭跃辉 时婧 王竞 姜斌 
上海市教委基金资助项目(编号:08YZ47);上海市科委基金资助项目(编号:10JC1409200);上海市交通大学医学院科技基金项目(编号:11XJ22014)
目的:探讨硫链丝菌素(thiostrepton,TST)对肺癌细胞A549增殖及其对AG1478药物敏感性的影响。方法:CCK-8法检测TST、AG1478单药及两药联用后A549细胞的增殖抑制率;Western blot检测不同浓度TST对A549细胞中FOXM1的表达影响;利用RNAi技术...
关键词:非小细胞肺癌 FOXM1 细胞增殖 RNA干扰 硫链丝菌素 药物敏感性 
Cloning, purification and characterization of the ribosomal protein L11 from E. coli
《American Journal of Molecular Biology》2011年第1期33-42,共10页Roumiana Todorova 
A high-expression system of L11 was constructed and investigated its interaction with other elements of the ribosome using physicochemical methods. The gene rplK, coding for the protein L11 from the E. coli 50S riboso...
关键词:CLONING Of L11 Rplk Gene Purification Under Denaturing Condition REFOLDING Interaction With RIBOSOME THIOSTREPTON Intrinsic DISORDER 
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