A novel approach for controlling translation initiation in mammalian cells is demonstrated based on the conditional attachment of eukaryotic translation initiation factor-binding proteins to the 3′UTR of mRNAs via sm...
Dear Editor, We report two NMR complex structures of PHDUHRF1 binding to unmodified or K9 trimethylated histone mils, which clarify a controversy regarding how the binding of UHRF1 to H3 tails is mediated. Based on o...
DNA methylation is the epigenetic mark with the longest history and that we probably understand best, yet we still have no adequate account for why specific DNA sequences are selected to become methylated. Gene-specif...
We thank Gerd Pfeifer (Beckman Research Institute of City of Hope) and Taiping Chen (Novartis Institutes for Biomedical Research) for helpful discussions and Jiemin Wong (East China Normal University) for critical reading of the manuscript. We are grateful to Masaki Okano (RIKEN Center for Developmental Biol- ogy) for providing Dnmt triple knockout ES cells. This work was supported by grants from the Ministry of Science and Technology of China (2005CB522400 and 2006CB943900), the National Natural Science Foundation of China (30730059) and the Shanghai Municipal Government (08dj 1400501, 0852S 11223) to GLX.
Cytosine methylation of genomic DNA controls gene expression and maintains genome stability. How a specific DNA sequence is targeted for methylation by a methyitransferase is largely unknown. Here, we show that histon...
The tumor suppressor PTEN controls a variety of biological processes including cell proliferation, growth, migration, and death. As a master cellular regulator, PTEN itself is also subjected to deliberated regulation ...