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作品数:379被引量:607H指数:10
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相关领域:医药卫生生物学更多>>
相关作者:胡姗姗周琼李刚张松林张婷更多>>
相关机构:中国科学技术大学湖北华中马瑞利汽车照明有限公司南京航空航天大学中国海洋大学更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划中国博士后科学基金国家高技术研究发展计划更多>>
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  • 期刊=Cell Researchx
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An engineered surrogate poly(A)tail to wag translation initiation
《Cell Research》2024年第2期95-96,共2页Stefan Lohse Wilfried Weber 
A novel approach for controlling translation initiation in mammalian cells is demonstrated based on the conditional attachment of eukaryotic translation initiation factor-binding proteins to the 3′UTR of mRNAs via sm...
关键词:TRANSLATION OVERCOME LIMITATIONS 
Structural basis for site-specific reading of unmodified R2 of histone H3 tail by UHRF1 PHD finger被引量:5
《Cell Research》2011年第9期1379-1382,共4页ChengkunWang  JieShen  ZhongzhengYang  PingChen  BinZhao  WeiHu  WenxianLan  XiaotianTong  HoumingWu  GuohongLi ChunyangCao 
Dear Editor, We report two NMR complex structures of PHDUHRF1 binding to unmodified or K9 trimethylated histone mils, which clarify a controversy regarding how the binding of UHRF1 to H3 tails is mediated. Based on o...
关键词:组蛋白H3 PHD 结构 修改 基础 阅读 尾部 站点 
DNA methylation: a new twist in the tail
《Cell Research》2011年第8期1155-1156,共2页Gavin Kelsey 
DNA methylation is the epigenetic mark with the longest history and that we probably understand best, yet we still have no adequate account for why specific DNA sequences are selected to become methylated. Gene-specif...
关键词:DNA甲基化 DNA甲基转移酶 基因组印记 催化结构域 尾部 DNA序列 遗传标记 抑癌基因 
Histone tails regulate DNA methylation by allosterically activating de novo methyltransferase被引量:17
《Cell Research》2011年第8期1172-1181,共10页Bin-Zhong Li Zheng Huang Qing-Yan Cui Xue-Hui Song Lin Du Albert Jeltsch Ping Chen Guohong Li En Li Guo-Liang Xu 
We thank Gerd Pfeifer (Beckman Research Institute of City of Hope) and Taiping Chen (Novartis Institutes for Biomedical Research) for helpful discussions and Jiemin Wong (East China Normal University) for critical reading of the manuscript. We are grateful to Masaki Okano (RIKEN Center for Developmental Biol- ogy) for providing Dnmt triple knockout ES cells. This work was supported by grants from the Ministry of Science and Technology of China (2005CB522400 and 2006CB943900), the National Natural Science Foundation of China (30730059) and the Shanghai Municipal Government (08dj 1400501, 0852S 11223) to GLX.
Cytosine methylation of genomic DNA controls gene expression and maintains genome stability. How a specific DNA sequence is targeted for methylation by a methyitransferase is largely unknown. Here, we show that histon...
关键词:de novo DNA methylation Dnmt3a Histone H3 tail PHD domain allosteric stimulation 
PTEN: a default gate-keeping tumor suppressor with a versatile tail被引量:7
《Cell Research》2008年第8期807-816,共10页Xinjiang Wang Xuejun Jiang 
The tumor suppressor PTEN controls a variety of biological processes including cell proliferation, growth, migration, and death. As a master cellular regulator, PTEN itself is also subjected to deliberated regulation ...
关键词:PTEN tumor suppressor posttranslational regulation UBIQUITINATION p53 
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