云南高校图书馆联盟文献共享服务平台- Β-DEFENSIN

Β-DEFENSIN: 作品数：33被引量：77H指数：5; 导出分析报告; 相关领域：农业科学更多>>; 相关作者：李思明姜葵王邦茂万欢英李彪更多>>; 相关机构：江西省农业科学院天津医科大学总医院上海交通大学医学院附属瑞金医院教育部更多>>; 相关期刊：《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》《Chinese Medical Journal》《浙江临床医学》更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金广东省自然科学基金更多>>

Incorporation of human β-defensin-1 into immunoliposomes to facilitate targeted autophagy therapy of colon carcinoma: 《World Journal of Clinical Oncology》2025年第3期8-12,共5页Ying Huang Xi-Ye Wang Jia-Yue Huang Zheng-Wei Huang; Supported by National Natural Science Foundation of China,No.82104070;Guangdong Universities Keynote Regions Special Funded Project,No.2022ZDZX2002。; Based on the discovery that humanβ-defensin-1(hBD-1)triggers autophagy in colon cancer cells and inhibits proliferation,we proposed the consideration of its druggability.As a protein,its stability,targetability and b...; 关键词：Humanβ-defensin-1 IMMUNOLIPOSOMES Colon cancer SW620 AUTOPHAGY

Humanβ-defensin-1 activates autophagy in human colon cancer cells via regulation of long non-coding RNA TCONS_00014506被引量：1: 《World Journal of Gastrointestinal Oncology》2024年第7期2894-2901,共8页Nabil Eid Fabian Davamani; Macroautophagy(hereafter referred to as autophagy)is a prosurvival mechanism for the clearance of damaged cellular components,specifically related to exposure to various stressors such as starvation,excessive ethanol ...; 关键词：Colon cancer Humanβ-defensin-1 Long noncoding RNA Mammalian target of rapamycin AUTOPHAGY LC3-II BECLIN-1 Autophagy flux

Humanβ-defensin-1 affects the mammalian target of rapamycin pathway and autophagy in colon cancer cells through long noncoding RNA TCONS_00014506被引量：4: 《World Journal of Gastrointestinal Oncology》2024年第4期1465-1478,共14页Yu-Xin Zhao Yan Cui Xin-Hong Li Wen-Hong Yang Shi-Xiang An Jia-Xian Cui Min-Yu Zhang Jing-Kun Lu Xuan Zhang Xiu-Mei Wang Li-Li Bao Peng-Wei Zhao; Supported by National Natural Science Foundation of China,No.82360329;Inner Mongolia Medical University General Project,No.YKD2023MS047;Inner Mongolia Health Commission Science and Technology Plan Project,No.202201275.; BACKGROUND Colorectal cancer has a low 5-year survival rate and high mortality.Humanβ-defensin-1(hBD-1)may play an integral function in the innate immune system,contributing to the recognition and destruction of canc...; 关键词：Colon cancer Humanβ-defensin-1 LncRNA Mammalian target of rapamycin AUTOPHAGY

A tetrahedral framework nucleic acid based multifunctional nanocapsule for tumor prophylactic mRNA vaccination被引量：2: 《Chinese Chemical Letters》2023年第7期169-175,共7页Yuhao Liu Songhang Li Shiyu Lin Sirong Shi Taoran Tian Bowen Zhang Tao Zhang Yunfeng Lin; supported by National Key R&D Program of China (No. 2019YFA0110600);National Natural Science Foundation of China (No. 81970916);Sichuan Province Youth Science and Technology Innovation Team (No. 2022JDTD0021);Research Funding from West China School/Hospital of Stomatology Sichuan University (No. RCDWJS2021-20);China Postdoctoral Science Foundation (No. 2022TQ0381)。; Synthetic antigen-encoding mRNA plays an increasingly significant role in tumor vaccine technology owing to its antigen-specific immune-activation. However, its immune efficacy is challenged by inferior delivery effic...; 关键词：Tetrahedral framework nucleic acid(tFNA) RNA nanovaccine Cytosine-phosphate-guanine(CpG)motifs Murineβ-defensin 2(mDF2β) Tumor immunotherapy

DEFB126 polymorphisms and association with idiopathic asthenozoospermia in China: 《Asian Journal of Andrology》2022年第6期607-614,共8页Jiao-Yu He Jian-Ying Peng Qiu-Fu Li Xiao-Li Lin Yan-Ru Cui Shi-Yu Ma Shi-Yun Fan Yi-Ran Liu Zhi-Lin Song Jun-Hang Deng Xia Wei Xian-Ping Ding; Idiopathic asthenozoospermia,a common factor in male infertility,is characterized by altered sperm motility function in fresh ejaculate.Although theβ-defensin 126(DEFB126)protein is associated with asthenozoospermia,...; 关键词：β-defensin 126 idiopathic asthenozoospermia in silico analysis single-nucleotide polymorphisms

Human β-defensin 2 enhances IL-1β production and pyroptosis through P2X7-mediated NLRP3 expression in macrophages被引量：1: 《BIOCELL》2022年第5期1197-1207,共11页PANPAN WANG GANG LI LI GAO CHUANJIANG ZHAO; This work was supported by National Natural Science Foundation of China(NSFC)(81500871);Natural Science Foundation of Guangdong Province(2016A030310214).; Periodontal disease is the leading cause of tooth loss,which is also a high-risk factor for other diseases including oral cancer and cardiovascular disease.Periodontitis is one of the most common type of periodontal d...; 关键词：PERIODONTITIS Humanβ-defensin 2 IL-1Β Signal transduction PYROPTOSIS

Human β-defensin-2 Enhances Anti-tumor Efficacy of Survivin-based Broad-spectrum DNA Vaccine in Mouse Tumor Model: 《Chinese Journal of Biomedical Engineering(English Edition)》2021年第4期139-151,171,共14页LUO Yan-xi WANG Ming-long WANG Shi-bing SUN Ting XIE Tian YAN Hui; Zhejiang Province Medical and Health Research Projects,grant number:2014KYA041;Natural Science Foundation of Zhejiang Province;grant number:LGF19H160032 and 2015C03055;the Key Programs of the National Natural Science Foundation of China;grant number:81730108; Objective:Malignant tumors greatly endanger and affect the quality of human life.Among antitumor biotherapy strategies,DNA vaccines hold promise in part because of their unique advantages.In this study,an effective br...; 关键词：survivin T34A β-defensin 2 molecular adjuvant ANTITUMOR DNA vaccine

Human β-defensin 3 gene modification promotes the osteogenic differentiation of human periodontal ligament cells and bone repair in periodontitis被引量：7: 《International Journal of Oral Science》2020年第2期162-171,共10页Lingjun Li Han Jiang Rixin Chen Jing Zhou Yin Xiao Yangheng Zhang Fuhua Yan; supported by the National Natural Science Foundation Project(No.81771078 and No.81570982);Jiangsu Provincial Medical Innovation Team(No.CXTDB2017014);the Nanjing Clinical Research Center for Oral Diseases(No.2019060009)。; Efforts to control inflammation and achieve better tissue repair in the treatment of periodontitis have been ongoing for years.Humanβ-defensin 3,a broad-spectrum antimicrobial peptide has been proven to have a variet...; 关键词：PERIOD PERIODONTAL LIGAMENT

DICER1 regulates antibacterial function of epididymis by modulating transcription of p-defensins被引量：4: 《Journal of Molecular Cell Biology》2019年第5期408-420,共13页Chunhua Tang Minjie Ni Shengsong Xie Yao Zhang Chaobao Zhang Zimei Ni Chen Chu Ligang Wu Yuchuan Zhou Yonglian Zhang; the National Basic Research Program of China(973 Program;2014CB943103);the National Natural Science Foundation of China(31471104,31671203,and 31571192).; DICER1 is a key enzyme responsible for the maturation of microRNAs. Recent evidences suggested that DICER1 and microRNAs expressed in epididymis were involved in the control of male fertility. However, the exact mecha...; 关键词：EPIDIDYMIS ANTIBACTERIAL PROPERTY DICER1 Β-DEFENSIN

β-defensin 2在肺缺血再灌注损伤中的表达及机制研究: 《宁夏医学杂志》2019年第1期8-11,I0003,共5页李桂荣戴友爱谈建新孙洁邹健聂晓伟陈静瑜; 南京医科大学科技发展基金项目(2016NJMUZD067); 目的探讨β-defensin 2在肺缺血再灌注损伤中的表达及机制。方法将16只SPF级雄性SD大鼠随机分成对照组(Control组)和肺缺血再灌注损伤组(LIRI组),LIRI组大鼠开胸,左肺缺血1 h,再灌注2 h,建立肺缺血再灌注损伤模型,Control组开胸2 h,收...; 关键词：肺缺血再灌注损伤炎症反应肺移植

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