CARCINOGENIC

作品数：52被引量：1002H指数：7
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Contamination assessment,source apportionment and associated health risks of PTEs in agricultural soil under five land-use patterns in Sanya,China
《China Geology》2024年第3期469-479,共11页Jian-zhou Yang Yan-gang Fu Qiu-li Gong Sheng-ming Ma Jing-jing Gong Jian-weng Gao Zhen-liang Wang Yong-wen Cai Shi-xin Tang 
supported by Open Foundation of the Key Laboratory of Coupling Process and Effect of Natural Resources Elements(No.2023KFKTB001);the Science&Technology Fundamental Resources Investigation Program(2022FY101800);the National Nonprofit Institute Research Grant of IGGE(AS2023D01);the projects of the China Geological Survey(DD20230309 and DD20190305);the National Natural Science Foundation of China(42002105)。
To understand the levels of potentially toxic elements(PTEs)contamination in soils and their effects on human health from different agricultural land use in Sanya,China.128 soil samples(64 topsoil samples and correspo...
关键词：Potentially toxic trace elements(PTEs) SOILS Land-use Geo-accumulation index(Igeo) Hazard quotient(HQ) Total carcinogenic risk index(TR) Source apportionment Health risk Agricutural geological survey engineering 
Human AKR1A1 involves in metabolic activation of carcinogenic aristolochic acidⅠ
《中国药理学与毒理学杂志》2024年第9期641-651,共11页GAO Zhenna YOU Xinyue LIU Weiying WU Jiaying XI Jing CAO Yiyi ZHANG Xiaohong ZHANG Xinyu LUAN Yang 
国家自然科学基金(81873081)。
OBJECTIVE To investigate whether aldo-keto reductases(AKRs)can act as a nitrore⁃ductase(NR)and bioactivate aristolochic acidⅠ(AA-Ⅰ)to produce AA-Ⅰ-DNA adducts.METHODS①Human-induced hepatocytes(hiHeps)and human bla...
关键词：metabolic activation nitro-reduction aldo-keto reductase superfamily aristolochic acidⅠ 
The combined detection of carcinoembryonic antigen,carcinogenic antigen 125,and carcinogenic antigen 19-9 in colorectal cancer patients
《World Journal of Gastrointestinal Surgery》2024年第7期2073-2079,共7页Ling-Zhen Gong Qian-Wen Wang Jie-Wen Zhu 
BACKGROUND Hepatic metastases are common and difficult to treat after colorectal cancer(CRC)surgery.The predictive value of carcinoembryonic antigen(CEA),cancer antigen(CA)125 and CA19-9 combined tests for liver metas...
关键词：Colorectal cancer Liver metastasis Serum markers Carcinoembryonic antigen Cancer antigen 125 Cancer antigen 19-9 Receiver operating characteristic analysis 
Molecular mechanism for the unusual enhancement of the second-step chemiluminescence production from the carcinogenic tetrabromohydroquinone and H2O_(2)
《Journal of Environmental Sciences》2024年第7期330-342,共13页Zi-Han Wang Chun-Hua Huang Zhi-Sheng Liu Li Mao Ben-Zhan Zhu 
supported by National Natural Science Foundation of China(Nos.22176205,22021003,92043301,21836005);“From 0 to 1”Original Innovation Project,the Basic Frontier Scientific Research Program,CAS(No.ZDBS-LYSLH027)。
We have found recently that two-step intrinsic hydroxyl radical(·OH)-dependent chemiluminescence(CL)could be produced by carcinogenic tetrahaloquinone and H_(2)O_(2).However,the first-step CL was too fast to clearly ...
关键词：Two-step chemiluminescence Bromohydroquinone Hydrogen peroxide Hydroxyl radical CRET 
The transcriptome analysis of cleft lip/palate-related PTCH1 variants in GMSM-K cells show carcinogenic potential
《BIOCELL》2023年第1期205-214,共10页MINGZHAO LI QIAN ZHANG WENBIN HUANG SHIYING ZHANG NAN JIANG XIAOSHUAI HUANG FENG CHEN 
This work was supported by the Natural Science Foundation of China(Nos.81870747,82170916);Clinical Medicine Plus X–Young Scholars Project(PKU2021LCXQ003);the Fundamental Research Funds for the Central Universities(BMU2021YJ001).
Cancer progression involves the sonic hedgehog(SHH)pathway,in which the receptor PTCH1 actives the downstream pathways.Dysfunction of PTCH1 can lead to nevoid basal cell carcinoma Syndrome(NBCCs)including neoplastic d...
关键词：CRISPR/Cas9 PTCH1 variant Carcinogenic potential Transcriptome sequencing 
Evaluation of concentrations of trace metal(loid)s in indigenous crab species and human health risk implications
《Emerging Contaminants》2022年第1期371-380,共10页Prince Onyedinma Ukaogo Jian Tang Ahamefula Anselm Ahuchaogu Okenwa Uchenna Igwe Anthony I.Obike Precious Onyinyechi Emole Loai Aljerf Ojah Emmanuel Onah Ali Tijjani Atem Bethel Ajong 
Despite the nutritional benefits of crab consumption,the bioaccumulation of hazardous trace metals(loid)in crabs can endanger consumers’health.The consumption of crab has received less attention.As,Cd,Cr,Cu,Li,Hg,Fe,...
关键词：CRAB ANTHROPOGENIC CARCINOGENIC Target hazard quotient BIOACCUMULATION Trace metals(loid) 
Dietary Intake, Carcinogenic and Non-Carcinogenic Risk Potentials of Lead, Cadmium, Mercury and Arsenic Exposure via Consumption of Dried Crayfish in Calabar, Nigeria
《Journal of Geoscience and Environment Protection》2022年第8期340-363,共24页Udiba U. Udiba Michael O. Odey Udeme U. Udofia Ekom R. Akpan John Ama Ekpo. E. Antai Monica U. Dan 
Intense pressure from both onshore and offshore oil exploration and exploitation activities, together with the accompanying urbanization and industrialization has resulted in massive contamination of land and water re...
关键词：Oil Industry Heavy Metals CRAYFISH Human Health Risk CARCINOGENIC NON-CARCINOGENIC 
Anti-aging and anti-carcinogenic effects of 1α,25-dihyroxyvitamin D_(3) on skin
《Plastic and Aesthetic Research》2022年第1期445-454,共10页Neena Philips Mikel Portillo-Esnaola Philips Samuel Maria Gallego-Rentero Tom Keller JanFranco 
Photoaging and carcinogenesis are facilitated by oxidative stress,inflammation,angiogenesis,and extracellular matrix(ECM)remodeling.Oxidative effects include DNA damage,membrane oxidation,lipid peroxidation,and altera...
关键词：Ultraviolet radiation superoxide dismutase p53 INTERLEUKINS tumor necrosis factor-α transforming growth factor-β vascular endothelial growth factor collagen ELASTIN matrix metalloproteinases 
Ecological and Human Health Risk Assessment of Pesticide Residues in Fish and Sediments from Vea Irrigation Reservoir被引量：2
《Journal of Environmental Protection》2021年第4期265-279,共15页Kanton Bello Richard Danladi Osei Akoto 
The low yield of food production ascribed to harm caused by pests has led to the application of pesticides to food crops. Pesticide residues from the application on crops are mostly found in foods that can cause disea...
关键词：PESTICIDES Risk CARCINOGENIC ORGANOCHLORINE ORGANOPHOSPHORUS Synthetic Pyrethroids 
Pharmacological aspects of fisetin
《Asian Pacific Journal of Tropical Biomedicine》2021年第1期1-9,共9页Lucia Dwi Antika Rita Marleta Dewi 
Over the past decades,epidemiological studies have concluded that a diet rich in plant-derived products plays a pivotal role in human health.Fisetin(3,3’,4’,7-tetrahydroxyflavone)is a hydrophobic polyphenolic compou...
关键词：FISETIN Anti-inflammatory ANTI-DIABETIC Anti-carcinogenic ANTI-OSTEOPOROSIS Cardioprotective activity 
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