supported by grants from the Fundamental Research Funds for the Central Universities(No.JD2231);the National Natural Science Foundation of China(No.82102038).
To the Editor:Postmenopausal osteoporosis is a typical bone metabolic disruption disease caused by estrogen deficiency,characterized by deteriorated bone structure,reduced bone mineral density(BMD),and thinned sclerot...
Over the past decades,epidemiological studies have concluded that a diet rich in plant-derived products plays a pivotal role in human health.Fisetin(3,3’,4’,7-tetrahydroxyflavone)is a hydrophobic polyphenolic compou...
supported by the National Natural Science Foundation of China(Grant Nos.81973291 to Xiaofei Chen,81573396 to Yifeng Chai,81973275 to Yongfang Yuan,81703674 to Yue Liu,81703779 to Rong Wang,81803815 to Shaozhan Wang and 81871099 to Xiao Chen);Fund of Shanghai Science and Technology Committee,China(19QA1411500 to Xiaofei Chen,17401900800 to Yongfang Yuan and 17YF1424700 to Yue Liu)
Osteoporosis is a bone metabolic disease caused by the imbalance between osteoblasts and osteoclasts due to excess osteoclastogenesis,manifesting in the decrease of bone density and bone strength.Scutellariae Radix sh...
Background: Alpinia officinarum Hance is valued as an edible medicinal plant. The rhizome is widely reported to have anticancer activity whereas little information is available on the aerial part. This study investiga...
National Natural Science Foundation of China,Grant/Award Number:31771628;Initial Program of Excellent Young High School Teachers,Guangdong,China,Grant/Award Number:Yue Jiaoshi Han [2016]6:YQ2015081;Guangdong Natural Science Fund for Distinguished Young Scholars,Grant/Award Number:2017A030306024
Background: The zebrafish(Danio rerio) has recently been shown to be an ideal model to study bone disease including osteoporosis. The zebrafish osteoporosis model could be induced by glucocorticoid treatment with chem...
Aims: Aim was to evaluate the anti-osteoporotic and anti-osteoarthritic activity of fresh water snail (Viviparous bengalensis) (VB) flesh extract (VBE) in experimental model. Settings and Design: Experimental osteopor...
Objective To observe the expression of matrix gla protein(MGP) mRNA in primary osteoblasts of Sprague-Dawley(SD) rat in vitro after treatment with anti-osteoporosis agents[vitamin K2,PTH,1,25(OH)2D3,and alendronate],a...
Objective The standard extract of Pueraria Lobata(SEP)was extracted from the traditional Chinese medicine Pueraria Lobata.and the anti-osteoporotic effect of SEP were evaluated in the paper.Methods The ovariotomied ra...
A simple and efficient procedure for synthesis of 1-hydroxymethylene-1,1-bisphos- phoates from aldehydes is described. This method was applied to the synthesis of novel catechol substituted bisphosphonates as the a...