supported by grants from the National Natural Science Foundation of China(82025020,82230072 and 32270874);the National Key R&D Program of China(2021YFA1100400 and 2021YFC2701400);the Science and Technology Commission of Shanghai Municipality(21140902300 and 22ZR1464000);Major Program of Development Fund for Shanghai Zhangjiang National Innovation Demonstration Zone(ZJ2018-ZD-004);Medical Research Project of Jing’an District,Shanghai(2023ZX03);Shanghai Municipal Health Commission(202240011);Peak Disciplines(Type IV)of Institutions of Higher Learning in Shanghai;sponsored by Shanghai Blue Cross Brain Hospital Co.,Ltd.,and Shanghai Tongji University Education Development Foundation.
Organ transplantation is the last-resort option to treat organ failure.However,less than 10%of patients benefit from this only option due to lack of major histocompatibility complex(MHC)-matched donor organs and 25%–...
funded by the 1.3.5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(No.20HXJ5014);Sichuan Science and Technology Program(No.2022NSFSC1298).
The loss of laryngeal function profoundly impacts the quality of life for specific patients with distorted laryngeal structure or total laryngectomy,particularly in social contexts.Consequently,allotransplantation has...
The respiratory tract is known to harbor a microbial community including bacteria,viruses,and fungi.New techniques contribute enormously to the identification of unknown or culture-independent species and reveal the i...
Restoration of upper extremity function poses a unique surgical challenge.With considerations ranging from ensuring appropriate skeletal support and musculotendinous and ligamentous anatomy,restoring adequate vascular...
Vascularized composite allotransplantation(VCA)is a novel surgical practice that involves the transplantation of multiple tissue types as a functional unit without the primary purpose of extending life.While VCA of th...
This work was supported by grants from the Ministry of Science and Technology of Taiwan,China(MOST 106-2314-B-182A-048-MY3);Chang Gung Medical Foundation(CMRPG3B0261,CMRPG6F0601-3,and CMRPG3C121-3).
The role of the vascularized bone marrow component as a continuous source of donor-derived hematopoietic stem cells that facilitate tolerance induction of vascularized composite allografts is not completely understood...
supported by the National Natural Science Foundation of China(81891002 and 81971178);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16040700);the National Key Research and Development Program of China(2017YFA0104701,2017YFA0104704,2016YFC1101501 and 2016YFC1101502)。
Spinal cord injury(SCI), especially complete transected SCI, leads to loss of cells and extracellular matrix and functional impairments. In a previous study, we transplanted adult spinal cord tissues(aSCTs) to replace...
Osseointegration(OI),targeted muscle reinnervation(TMR),and vascularized composite allotransplantation(VCA)are just a few ways by which our reconstructive ladder is evolving.It is important to recognize that amputatio...
The development of vascularized composite allotransplantation (VCA) and its clinical need has led to the need for more animal models to study and perform the research required to further this specialty in terms of fun...
This study was financially supported by the National Key R&D Program of China(grant No.2017YFC1200503);the National Key Research Program(grant No.2016YFD0500400 and grant No.2017ZX10104001).
Background:Rabies,for which the mortality rate is almost 100%,is a zoonotic viral disease that can be transmitted via solid organs or tissue allotransplantation.Dozens of deaths from rabies via solid organs or tissues...