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作品数：44被引量：87H指数：5
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相关领域：医药卫生更多>>
相关作者：吴蔚然朱子涛周宝玉陈宏王国相更多>>
相关机构：中国科学院中日友好医院吉林大学白求恩第一医院中山大学附属第一医院更多>>
相关期刊：《Stroke & Vascular Neurology》《Neural Regeneration Research》《China Medical Abstracts(Internal Medicine)》《Neuroscience Bulletin》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划天津市自然科学基金湖北省自然科学基金更多>>
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Synaptic and synchronic impairments in subcortical brain regions associated with early non-cognitive dysfunction in Alzheimer's disease
《Neural Regeneration Research》2026年第1期248-264,共17页Nicolás Riffo-Lepe Juliana González-Sanmiguel Lorena Armijo-Weingart Paulina Saavedra-Sieyes David Hernandez Gerson Ramos Loreto S.San Martín Luis G.Aguayo 
supported by ANID/CONICYT Fondecyt Regular 1221080(to LGA);Fondecyt Postdoctoral fellow 3210260(to LAW);ANID PhD fellowship 21202521(to NRL);21211228(to JGS);21211758(to PSS)and 21230078(to DH)。
For many decades,Alzheimer's disease research has primarily focused on impairments within cortical and hippocampal regions,which are thought to be related to cognitive dysfunctions such as memory and language deficits...
关键词：Alzheimer's disease AMPA receptors AMYGDALA epilepsy gamma-aminobutyric acid GLUTAMATE hippocampus NEURODEGENERATION neuronal excitability N-methyl-D-aspartate receptors non-cognitive nucleus accumbens 
Neural Network Mechanisms Underlying General Anesthesia:Cortical and Subcortical Nuclei
《Neuroscience Bulletin》2024年第12期1995-2011,共17页Yue Hu Yun Wang Lingjing Zhang Mengqiang Luo Yingwei Wang 
supported by the National Natural Science Foundation of China(82271292,82371286,and 82101350);the Foundation of Shanghai Municipal Science and Technology Medical Innovation Research Project(23Y21900600).
General anesthesia plays a significant role in modern medicine.However,the precise mechanism of general anesthesia remains unclear,posing a key scientific challenge in anesthesiology.Advances in neuroscience technique...
关键词：General anesthesia Neural network CORTEX Subcortical nuclei CONSCIOUSNESS 
Imitating and exploring the human brain’s resting and task-performing states via brain computing:scaling and architecture
《National Science Review》2024年第5期10-21,共12页Wenlian Lu Longbin Zeng Jiexiang Wang Shitong Xiang Yang Qi Qibao Zheng Ningsheng Xu Jianfeng Feng DTB Consortium 
supported by the National Key R&D Program of China(2019YFA0709502);the ShanghaiMunicipal Science and Technology Major Project(2018SHZDZX01);the Zhejiang Lab,the Shanghai Center for Brain Science and Brain-Inspired Technology,the Programme of Introducing Talents of Discipline to Universities(B18015);the National Natural Science Foundation of China(62072111 and 62306078).
A computational human brain model with the voxel-wise assimilation method was established based on individual structural and functional imaging data.We found that the more similar the brain model is to the biological ...
关键词：digital twin brain computational cortico-subcortical model fMRI data assimilation interoceptive circuit 
Treadmill training in Parkinson's disease:possible role of prefrontal modifications in the improved cortical-subcortical network function
《Neural Regeneration Research》2024年第2期407-408,共2页Hao Ding Amgad Droby Abdul Rauf Anwar Jeffrey M.Hausdorff Bahman Nasseroleslami Anat Mirelman Inbal Maidan Muthuraman Muthuraman 
supported by the Deutsche Forschungsgemeinschaft(DFG,German Research Foundation),No.424778381-TRR 295(to MM)。
Parkinson’s disease(PD)is a complex neurodegenerative disorder characterized by a range of motor symptoms such as bradykinesia,resting tremor,rigidity,and postural instability,as well as non-motor symptoms,such as de...
关键词：RIGIDITY FATIGUE 
Cortico–subcortical spatiotemporal dynamics in Parkinson’s disease can be modulated by transcranial alternating current stimulation被引量：1
《Brain Science Advances》2023年第2期114-135,共22页Tiantian Liu Zilong Yan Ziteng Han Jian Zhang Boyan Fang Tianyi Yan 
This work was supported by the National Natural Science Foundation of China(Grant Nos.U20A20191,82071912,12104049,82202291);the Fundamental Research Funds for the Central Universities(Grant No.2021CX11011);the National Key Research and Development Program of China(Grant No.2020YFC2007305).
Objective:We investigated changes in cortico–subcortical spatiotemporal dynamics to explore the treatment mechanisms oftranscranial alternating current stimulation(tACS)in patientswith Parkinson’s disease(PD).Method...
关键词：spatiotemporal dynamics cortico–subcortical co-activation pattern transcranial alternating current stimulation Parkinson’s disease resting-state functional MRI 
Morphological changes in Parkinson's disease based on magnetic resonance imaging:A mini-review of subcortical structures segmentation and shape analysis被引量：1
《World Journal of Psychiatry》2022年第12期1356-1366,共11页Jin-Huan Deng Han-Wen Zhang Xiao-Lei Liu Hua-Zhen Deng Fan Lin 
Supported by the Guangdong Basic and Applied Basic Research Foundation,No.2021A1515220131;Youth Exploration Fund of Shenzhen Health Economics Society,No.202211;and Clinical Research Project of Shenzhen Second People’s Hospital,No.223375022.
Parkinson's disease(PD)is a neurodegenerative disorder caused by the loss of dopaminergic neurons in the substantia nigra,resulting in clinical symptoms,including bradykinesia,resting tremor,rigidity,and postural inst...
关键词：Parkinson's disease Dopaminergic neurons Magnetic resonance imaging Substantia nigra MORPHOLOGICAL 
The grey matter volume and fractional amplitude of low-frequency fluctuation alterations in cerebral small vessel disease patients with subcortical ischemic depression and their relationship with brain derived neurotrophic factor gene polymorphism
《China Medical Abstracts(Internal Medicine)》2022年第2期123-124,共2页ZHOU Xia 
Objective To investigate the relationship between brain derived neurotrophic factor (BDNF) gene polymorphism and the change of grey matter volume (GMV) and fractional amplitude of low-frequency fluctuation(fALFF) in c...
关键词：PATIENTS alterations cerebral 
Surface-based map plasticity of brain regions related to sensory motor and pain information processing after osteonecrosis of the femoral head被引量：4
《Neural Regeneration Research》2022年第4期806-811,共6页Jie Ma Xu-Yun Hua Mou-Xiong Zheng Jia-Jia Wu Bei-Bei Huo Xiang-Xin Xing Sheng-Yi Feng Bo Li Jian-Guang Xu 
supported by National Key R&D Program of China,No.2018YFC2001600(to JGX);the National Natural Science Foundation of China,Nos.81802249(to XYH),81871836(to MXZ);a grant from Shanghai Science and Technology Committee of China,Nos.18511108300(to JGX),18441903903900(to XYH),18441903800(to MXZ);Three-Year Action Plan for Traditional Chinese Medicine Development from Shanghai Municipal Health Commission of China,No.ZY(2018-2020)-ZWB-1001-CPJS49(to BL);ZY(2018-2020)-RCPY-3007(to JM);Traditional Chinese Medicine Diagnosis and Treatment Technology Improvement Project from Shanghai Municipal Commission of Health and Family Planning of China,No.Zyjx-2017006(to BL);Special Project of Postgraduate Innovation Training of China,No.A1-GY20-204-0107(to JM)。
Pain is one of the manifestations of hip disorder and has been proven to lead to the remodeling of somatotopic map plasticity in the cortex.However,most studies are volume-based which may lead to inaccurate anatomical...
关键词：cortical thickness functional connectivity hip disorder osteonecrosis of the femoral head Re Ho sensorimotor cortex surface-based map plasticity volume of subcortical gray matter nuclei 
Assessment of structural brain changes in patients with type 2 diabetes mellitus using the MRI-based brain atrophy and lesion index被引量：8
《Neural Regeneration Research》2022年第3期618-624,共7页Heng Zhao Fang Wang Guang-Hua Luo Hao Lei Fei Peng Qiu-Ping Ren Wei Chen Yan-Fang Wu Li-Chun Yin Jin-Cai Liu Shi-Nong Pan 
supported by the National Natural Science Foundation of China,No.81271538 (to SNP);345 Talent Project and the Natural Science Foundation of Liaoning Province of China,No.2019-ZD-0794 (to SNP);the Natural Science Foundation of Hunan Province of China,Nos.2017JJ2225 (to JCL),2018JJ2357 (to GHL);Hunan Provincial Science and Technology Innovation Program of China,No.2017SK50203 (to HZ)。
Patients with type 2 diabetes mellitus(T2 DM) often have cognitive impairment and structural brain abnormalities.The magnetic resonance imaging(MRI)-based brain atrophy and lesion index can be used to evaluate common ...
关键词：brain atrophy and lesion index cognitive impairments gray matter lesions magnetic resonance imaging Mini-Mental State Examination structural brain subcortical dilated perivascular spaces T1-weighted image T2-weighted image type 2 diabetes mellitus 
The Amygdala Responds Rapidly to Flashes Linked to Direct Retinal Innervation:A Flash-evoked Potential Study Across Cortical and Subcortical Visual Pathways被引量：2
《Neuroscience Bulletin》2021年第8期1107-1118,共12页Yanmei Chen Yiling Ni Jianhong Zhou Hua Zhou Qian Zhong Xinyue Li Jichuan Zhang Yuanye Ma Jingkuan Wei 
the National Key Research and Development Program of China(2018YFA0108503);the National Natural Science Foundation of China(81760251 and 81560234);the Yunnan Provincial Natural Science Foundation(2018FB118 and KKSY201626001).
Rapid detection and response to visual threats are critical for survival in animals.The amygdala(AMY)is hypothesized to be involved in this process,but how it interacts with the visual system to do this remains unclea...
关键词：Subcortical visual pathway AMYGDALA Superior colliculus Corticosterone Flash-evoked potential 
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