In this article,we consider a new family of exponential type estimators for estimating the unknown population mean of the study variable.We propose estimators taking advantage of the auxiliary variable information und...
supported by the National Natural Science Foundation of China[grant number 52203370]
Objective To investigate the value of pretreatment inflammatory-nutritional biomarkers in predicting the pathological response of locally advanced rectal cancer(LARC)after neoadjuvant chemotherapy(nCT).Methods This re...
Introduction: Malnutrition is a public health problem. It is responsible for high morbidity and mortality in children aged 6 - 59 months. The aim of this study was to determine the outcome of children with complicated...
BACKGROUND There is paucity of data on outcomes of acute severe ulcerative colitis(ASUC)in older adults(≥60 years of age).AIM To assess steroid non-response rates during the index admission for ASUC in older adults.S...
supported by the National Key R&D Program of China(2019YFC1315701 to Y.S.);sponsored by National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital&Shenzhen Hospital,Chinese Academic of Medical Sciences and Peking Union Medical College,Shenzhen(SZ2020ZD004,E010121002);supported by Sanming Project of Medicine in Shenzhen(No.SZSM201812062,No.SZSM201612097);Shenzhen Science and Technology Program(KCXFZ20201221173008022);Shenzhen Key Medical Discipline Construction Fund(No.SZXK075).
Cancers are highly complex diseases that are characterized by not only the overgrowth of malignant cells but also an altered immune response.The inhibition and reprogramming of the immune system play critical roles in...
supported by the National Natural Science Foundation of China[Grant No.81573507,81473283,81173131,and 81320108027];the Natural Major Projects for science and technology development from Science and Technology Ministry of China[Grant No.2012ZX09506001-004];the Major Scientific and Technological Project of Guangdong Province[Grant No.2011A080300001];the Medical Scientific Research Foundation of Guangdong Province of China[Grant No.A2020123].
Background:Infliximab(IFX)is the first-line treatment for patients with Crohn’s disease(CD)and is noted for its relatively high cost.The therapeutic efficacy of IFX has noticeable individual differences.Known single-...
supported by grants from the National Natural Science Foundation of China(#81870374,#81670498);Guangdong Science and Technology(#2017A030306021);Science and Technology Innovation Young Talents of Guangdong Special Support Plan(#2016TQ03R296);the Fundamental Research Funds for the Central Universities(#19ykzd11).
Background:Infliximab(IFX)is effective at inducing and maintaining clinical remission and mucosal healing in patients with Crohn’s disease(CD);however,9%–40%of patients do not respond to primary IFX treatment.This s...
financially supported by the National Natural Science Foundation of China(81570370);CAMS Innovation Fund for Medical Sciences(2017-I2M-1-009)
Background Cardiac resynchronization therapy(CRT)is a highly effective treatment in patients with a class I recommendation.However,a small proportion of the strictly selected patients still fail to respond.This study ...
Objective To evaluate factors relevant to primarynon-response in patients with Crohn's disease undergoinginfliximab ( IFX) treatment at week 14. Methods Patientswith Crohn's disease in the Third Hospital of PekingUniv...
supported by Grants from the National Major Science and Technology Project for Infectious Diseases of China(2012ZX10004503);Major State Basic Research Development Program of China(973 Program;No.2013CB530505)
Dear Editor,Natural killer(NK)cells are lymphocytes that play important roles in the host defense against hepatitis C virus(HCV)infection.Killer cell immunoglobulin-like receptors(KIRs)are a group of regulatory molecu...