URACILS

作品数：9被引量：4H指数：1
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相关领域：理学更多>>
相关作者：郭盈闫寒王孝伟张志丽刘俊义更多>>
相关机构：北京大学更多>>
相关期刊：《Science China Chemistry》《Chinese Journal of Structural Chemistry》《Journal of Chinese Pharmaceutical Sciences》《Chinese Chemical Letters》更多>>
相关基金：国家自然科学基金更多>>
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Practical and sustainable approach for clean preparation of 5-organylselanyl uracils
《Chinese Chemical Letters》2021年第1期475-479,共5页Jin-Yang Chen Chun-Tao Zhong Qing-Wen Gui Yuan-Ming Zhou Yang-Yang Fang Kai-Jian Liu Ying-Wu Lin Zhong Cao Wei-Min He 
financial support from the National Natural Science Foundation of China(No.21902014);the Basic Frontier Research Project of Chongqing(No.Cstc2018jcyjAX0051);Hunan Provincial Natural Science Foundation of China(No.2019JJ20008)。
An eco-friendly,sustainable and practical method for the efficient preparation of 5-organylselanyl uracils through the electrochemical selenylation of uracils and dio rganyl diselenides at room temperature under oxida...
关键词：Selenylation ELECTROCHEMISTRY Diorganyl diselenides Atom-economy RECYCLABILITY 
Benign perfluoroalkylation of uracils and uracil nucleosides via visible light-induced photoredox catalysis
《Chinese Chemical Letters》2017年第8期1751-1754,共4页Ben-Hou Zhang Jing-Jing Kong Yang Huang Yue-Guang Lou Xiao-Fei Li Chun-Yang He 
financially supported by the Young Talents Cultivation Program of the China Association for Science and Technology(No.2015-41);The Training Programme Foundation for the Talents of the Zun Yi Science and Technology Bureau(No.201540);Key Programs of Guizhou Province(125 Program,No.2015039);The Natural Science Foundation of Jiangsu Province(No.BK20141265)
In this work, an efficient and facile method for the preparation of 5-perfluoroalkylation uracils and uracil nucleosides through visible-light-mediated reaction has been developed. The reaction processes in high effic...
关键词：Uracils Uracil Nucleosides Blue LED Photoredox catalysis Perfluoroalkylation 
Exploration on the site-preference of the hydrogen bonding interactions between uracils and/or thymines被引量：1
《Science China Chemistry》2011年第11期1759-1769,共11页LI Yang WANG ChangSheng 
supported by the National Natural Science Foundation of China (20973088);the Educational Department of Liaoning Province (2007T091, 2008T106)
Understanding the mechanisms underlying the assembly of nucleobases is a great challenge. The ability to deeply understand how nucleobases interact with themselves as well as with other molecules will allow us to gain...
关键词：URACILS thymines binding energies hydrogen-bonded dimers hydrogen-bonded trimers hydrogen-bonded tetramers 
Synthesis and anti-HIV-1 activity evaluation of N-1-alkyl-5-halogeno-6-alkylamino uracils as novel non-nucleoside HIV-1 reverse transcriptase inhibitors
《Journal of Chinese Pharmaceutical Sciences》2011年第2X期146-153,共8页闫寒 王孝伟 郭盈 张志丽 刘俊义 
National Natural Science Foundation of China (Grant No.20672008 and 20972011).
N-1-alkyl-5-halogeno-6-alkylamino uracils,which are novel 1-[(2-hydroxyethoxy) methyl]-6-(phenylthio) thymine (HEPT) analogues,were synthesized as the selective and potent non-nucleoside human immunodeficiency virus(H...
关键词：HIV-1 reverse transcriptase Non-nucleoside reverse transcriptase inhibitors HEPT analogues 
Synthesis and anti-HIV-1 activity evaluation of N-l-alkyl-5-halogeno-6- alkylamino uracils as novel non-nucleoside HIV-I reverse transcriptase inhibitors
《Journal of Chinese Pharmaceutical Sciences》2011年第2期146-153,共8页Han Yan Xiao-Wei Wang Ying Guo Zhi-Li Zhang Jun-Yi Liu 
Foundation items： National Natural Science Foundation of China （Grant No. 20672008 and 20972011）.
N-l-alkyl-5-halogeno-6-alkylamino uracils, which are novel l-[（2-hydroxyethoxy） methyl]-6-（phenylthio） thymine （HEPT） analogues, were synthesized as the selective and potent non-nucleoside human immunodeficiency...
关键词：HIV-1 reverse transeriptase Non-nucleoside reverse transcriptase inhibitors HEPT analogues 
2D-QSARs of 1-Alkoxymethyl-5-alkyl-6-naphthylmethyl Uracils as HEPT Analogues with Anti-HIV-1 Activity被引量：1
《Chinese Journal of Structural Chemistry》2008年第12期1519-1525,共7页殷丽琴 杨晓梅 余仕问 姚立峰 胡栋宝 谢小光 
supported by NNSFC (20563005)
The two-dimensional Quantitative Structure-Activity Relationship （2D-QSAR） models have been developed to estimate and predict the inhibitory activities of a series of HEPT analogues against HIV-1 by using quantum ch...
关键词：QSAR quantum chemical parameters stepwise multiple regression Cross-Validation methodology 
Synthesis of 1-[(O,O-diphenyl phosphonyl)arylmethyleneamino carbonylmethyl]uracils被引量：2
《Chinese Chemical Letters》1999年第9期739-740,共2页Xue Jun LIU Guo Chen CHI Ru Yu CHEN(Institute and National Key Laboratory of Elemento-Organic Chemistry, Nankai UniversityTianjin 300071) 
A new series of compounds, 1-[(O,O-diphenyl phosphonyl)arylmethylene aminocarbonylmethyl]uracils, were synthesized in yield of 54.6-72.0% with DCC/BtOH as the coupling reagent, and their biological activities are bein...
关键词：URACIL alpha-aminophosphonic acid 
Synthesis of Novel New Substituted(Thio)uracils
《厦门大学学报（自然科学版）》1999年第S1期265-265,共1页
Supported by the National Natural Foundation of China !(No. 29702006. 29832050)
关键词：Synthesis of Novel New Substituted Thio)uracils 
Structure Based Library Approach to Photosynthesis Inhibitors:The Solid Phase Synthesis of Hydro-Uracils and Thiouracils
《Chinese Chemical Letters》1998年第2期139-142,共4页Yu, AM Yang, HZ Zhang, ZP 
A general method for the solid phase synthesis of hydro-uracils and thiouracils is described. Resino ester 2 reacts with various primary amines to give secondary amines 3, which are converted to the resino ureas (thio...
关键词：solid phase synthesis hydro-uracils and thiouracils photosynthesis inhibitors 
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