RALTITREXED

作品数：22被引量：53H指数：4
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相关作者：张楠森王平全杨惠娣高红军李书权更多>>
相关机构：上海第二医科大学附属仁济医院解放军第307医院武警辽宁省总队医院上海交通大学更多>>
相关期刊：《Journal of Interventional Medicine》《中华医学信息导报》《有机化学》《Cancer Communications》更多>>
相关基金：国家自然科学基金北京市自然科学基金国家重点基础研究发展计划广东省自然科学基金更多>>
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SALIRI-based(raltitrexed plus irinotecan)therapy as a second-line treatment for patients with metastatic colorectal cancer(SALLY):A prospective,multicenter,non-interventional,registry study
《Cancer Communications》2024年第8期910-914,共5页Shuqui Qin Jin Li Aiping Zhou Yanqiao Zhang Xianglin Yuan Liangjun Zhu Baoli Qin Shan Zeng Lin Shen Ying Yuan Weibo Wang Jun Liang Xianwen Zhang Feng Ye Ping Chen HuaizhangWang Zhenyan Yu Lu Yue Yong Fang Jianping Xiong Jianwei Yang Yiye Wan Xianli Yin Wenling Wang Nong Xu XiaohongWang Zemin Xiao Huafang Su YingWang Kangsheng Gu Shuiping Tu Zishu Wang Bo Liu Xiaohua Hu Weixian Liu Xiaofeng Li 
Primary chemotherapy options for colorectal cancer(CRC)involve four key drugs:fluorouracils(5-FU),oxaliplatin,irinotecan and raltitrexed.The first-line regimen consists of 5-FU and leucovorin combined with oxaliplatin...
关键词：drugs chemotherapy FOLFIRI 
Comparing effectiveness and safety of paclitaxel plus raltitrexed vs. paclitaxel alone in second-line palliative chemotherapy for metastatic gastric adenocarcinoma: A randomized phase Ⅱ clinical trial
《Cancer Biology & Medicine》2023年第9期682-688,共7页Xiaoying Zhao Zhiyu Chen Xiaowei Zhang Xiaodong Zhu Wen Zhang Lixin Qiu Chenchen Wang Mingzhu Huang Zhe Zhang Wenhua Li Lei Yang Weijian Guo 
Objective:Paclitaxel(P)is a standard second-line chemotherapy in the treatment of advanced gastric cancer.This study compared the clinical outcome of a paclitaxel plus raltitrexed(RP)regimen as second-line treatment i...
关键词：Gastric adenocarcinoma RALTITREXED PACLITAXEL second-line palliative chemotherapy 
Hepatic arterial infusion of oxaliplatin plus raltitrexed in unresectable hepatocellular carcinoma with or without portal vein tumour thrombosis被引量：1
《Gastroenterology Report》2022年第1期341-348,共8页Shiguang Chen Wenchang Yu Kongzhi Zhang Weifu Liu Xiaolong Wang Chuanben Chen 
supported by the Guiding Project of Science and Technology Program of Fujian Province,China[grant number:2019Y0060].
Background Unresectable hepatocellular carcinoma(HCC)has a poor prognosis.According to the HCC management guidelines in China,the standard treatment of Barcelona Clinic Liver Cancer(BCLC)stage B or C HCC with portal v...
关键词：hepatic arterial infusion hepatocellular carcinoma OXALIPLATIN portal vein tumour thrombosis RALTITREXED 
Raltitrexed as a synergistic hyperthermia chemotherapy drug screened in patient-derived colorectal cancer organoids被引量：2
《Cancer Biology & Medicine》2021年第3期750-762,共13页Lisi Zeng Quanxing Liao Haoran Zhao Shengwei Jiang Xianzi Yang Hongsheng Tang Qingjun He Xiansheng Yang Shuxian Fang Jinfu He Weiwen Cui Laiqiang Huang Shaohua Ma Shuzhong Cui 
supported by grants from the National Natural Science Foundation of China(Grant Nos.81972918 and 61971255);Shenzhen Science and Technology Innovation Committee(Grant No.KQJSCX20180327143623167);NANJING CHIA TAI TIANQING Company,Foundation for Young Innovative Talents in Education of Guangdong(Grant No.2017KQNCX161);Natural Science Foundation of Guangdong Province(Grant No.2018A030310249);Key Clinical Technique of Guangzhou(Grant No.2019ZD16)。
Objective:Organoids have recently been used as in vitro models to screen chemotherapy drugs in combination with hyperthermia treatment in colorectal cancer.Our research aimed to establish a library of patient-derived ...
关键词：Colorectal cancer ORGANOIDS hyperthermia chemotherapy sensitization enhancement ratio RALTITREXED 
Structural analysis of a shrimp thymidylate synthase reveals species-specific interactions with dUMP and raltitrexed被引量：1
《Journal of Oceanology and Limnology》2020年第6期1891-1899,共9页LIU Changshui ZANG Kun LI Shihao LI Fuhua MA Qingjun 
Supported by the National Natural Science Foundation of China(Nos.31572660,31872600);the“1000 Talents Program”,and the Qingdao Innovation Leadership Project(No.18-1-2-12-zhc)。
Thymidylate synthase(TS)is a key enzyme in the de novo biosynthesis of thymidine monophosphate,serving as a well-known drug target in chemotherapy against cancers and infectious diseases.Additional to its clinical val...
关键词：thymidylate synthase(TS) closed conformation deoxyuridine monophosphate(dUMP) thymidine monophosphate(TMP) RALTITREXED Litopenaeus vannamei 
PhaseⅡstudy of induction chemotherapy followed by concurrent chemoradiotherapy with raltitrexed and cisplatin in locally advanced nasopharyngeal carcinoma被引量：5
《Chinese Journal of Cancer Research》2020年第5期665-672,共8页Yuan Wu Xueyan Wei Zilong Yuan Hongbin Xu Yanping Li Ying Li Liu Hu Guang Han Yu Qian Desheng Hu 
supported by The Radiation Therapy Major Project of the Ministry of Science and Technology of China(No.2016YFC0105711);supported partly by Natural Science Foundation of China(No.81401913)。
Objective:For locally advanced nasopharyngeal carcinoma(LA-NPC)patients,high incidences of distant metastases and severe treatment related toxicities are the main obstacles needed to be overcome.Raltitrexed,a specific...
关键词：Nasopharyngeal carcinoma RALTITREXED CISPLATIN induction chemotherapy concurrent chemoradiotherapy 
_D-Proline capped gold nanoclusters for turn-on detection of serum Raltitrexed
《Chinese Chemical Letters》2019年第9期1627-1630,共4页Weifei Lan Qiqi Tan Juan Qiao Gangyi Shen Li Qi 
the financial support from the National Natural Science Foundation of China (Nos. 21575144, 91732103, 21874138, 21635008, 21621062)
With _D-proline as the reducing and capping agent, fluorescent gold nanoclusters were rapidly prepared(_D-Pro@AuNCs) within 10 min at 100℃. In the present of gold nanoparticles, the fluorescence of _DPro@AuNCs was re...
关键词：D-Pro capped gold NANOCLUSTERS Fluorescent probe Turn on Sensing SERUM RTX 
Safety and efficacy of hepatic arterial infusion chemotherapy with raltitrexed and oxaliplatin post-transarterial chemoembolization for unresectable hepatocellular carcinoma被引量：9
《Journal of Interventional Medicine》2019年第2期91-96,共6页Baojiang Liu Xu Zhu Song Gao Jianhai Guo Xiaodong Wang Guang Cao Linzhong Zhu Peng Liu Haifeng Xu Hui Chen Xin Zhang Shaoxing Liu Fuxin Kou 
supported by the National Natural Science Foundation of China(81571781).
Objective:To investigate the safety,efficacy,and prognostic factors of hepatic arterial infusion chemotherapy(HAIC)with raltitrexed and oxaliplatin post-transarterial chemoembolization(TACE)for unresectable hepatocell...
关键词：Hepatocellular carcinoma TRANSCATHETER ARTERIAL CHEMOEMBOLIZATION (TACE) Hepatic ARTERIAL infusion chemotherapy(HAIC) OXALIPLATIN RALTITREXED 
Effects of Huachansu capsules combined with raltitrexed and olisaplatin on advanced colorectal cancer immunity, tumor markers, matrix metalloproteinases and angiogenesis
《Journal of Hainan Medical University》2018年第23期46-49,共4页Xiao-Feng Sha Zeng-Fang Song Jie Ding Jiao Zhang 
Objective:To investigate the effects of Huachansu capsules combined with raltitrexed and olisaplatin on advanced colorectal cancer immunity, tumor markers, matrix metalloproteinases and angiogenesis.Methods: Eighty-tw...
关键词：Huachansu CAPSULE RALTITREXED Olithaplatin Colorectal cancer Tumor marker Matrix METALLOPROTEINASE ANGIOGENESIS 
Transarterial embolization and low-dose continuous hepatic arterial infusion chemotherapy with oxaliplatin and raltitrexed for hepatocellular carcinoma with major portal vein tumor thrombus被引量：6
《World Journal of Gastroenterology》2018年第23期2501-2507,共7页Lin-Zhong Zhu Song Xu Hai-Long Qian 
the National Key R and D Program of China,No.2016YFC0106604;the National Natural Science Foundation of China,No.81502591
AIM To determine the efficacy and safety of transarterial embolization and low-dose continuous hepatic arterial infusion chemotherapy with oxaliplatin and raltitrexed in hepatocellular carcinoma(HCC) with major portal...
关键词：Transarterial EMBOLIZATION OXALIPLATIN MAJOR portal vein tumor THROMBUS RALTITREXED CONTINUOUS hepatic arterial infusion chemotherapy 
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