LUNG

作品数：1661被引量：4184H指数：23
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Oxidative stress-triggered Wnt signaling perturbation characterizes the tipping point of lung adeno-to-squamous transdifferentiation被引量：4
《Signal Transduction and Targeted Therapy》2023年第2期730-743,共14页Zhaoyuan Fang Xiangkun Han Yueqing Chen Xinyuan Tong Yun Xue Shun Yao Shijie Tang Yunjian Pan Yihua Sun Xue Wang Yujuan Jin Haiquan Chen Liang Hu Lijian Hui Lin Li Luonan Chen Hongbin Ji 
We thank Drs.Tyler Jacks,Ronald A.DePinho,Kwok-kin Wong,and Lijian Hui for the generous gift of various mouse strains.We also thank Ruiqi Wang,Rui Liu,Pei Chen,Chao Zheng,and Jifan Shi for helpful discussion.This work was supported by the National Basic Research Program of China(Nos.2017YFA0505500 to H.J.and L.C.,2020YFA0803300 to H.J.);the National Natural Science Foundation of China(Nos.91731314,82030083,31621003,81872312,82011540007 to H.J.,12131020,31930022,12026608 to L.C.,82273093 to Z.F.,81871875,82173340 to L.H.,81802279 to H.H.,81902326 to X.W.,81402371 to Y.J.);the Strategic Priority Research Program of the Chinese Academy of Sciences(Nos.XDB19020201 to H.J.,XDB38040400 to L.C.);Basic Frontier Scientific Research Program of Chinese Academy of Science(No.ZDBS-LY-SM006 to H.J.);International Cooperation Project of Chinese Academy of Sciences(No.153D31KYSB20190035 to H.J.);the Science and Technology Commission of Shanghai Municipality(No.21ZR1470300 to L.H.);the Youth Innovation Promotion Association CAS(No.Y919S31371 to X.W.);Special Fund for Science and Technology Innovation Strategy of Guangdong Province(Nos.2021B0909050004,2021B0909060002 to L.C.);Major Key Project of PCL(No.PCL2021A12 to L.C.);JST Moonshot R&D Project(No.JPMJMS2021 to L.C.).
Lkb1 deficiency confers the Kras-mutant lung cancer with strong plasticity and the potential for adeno-to-squamous transdifferentiation(AST).However,it remains largely unknown how Lkb1 deficiency dynamically regulates...
关键词：SQUAMOUS HOMEOSTASIS LUNG 
Highly pathogenic coronavirus N protein aggravates inflammation by MASP-2-mediated lectin complement pathway overactivation被引量：5
《Signal Transduction and Targeted Therapy》2022年第10期3940-3954,共15页Ting Gao Lin Zhu Hainan Liu Xiaopeng Zhang Tingting Wang Yangbo Fu Hongzhen Li Qincai Dong Yong Hu Zhang Zhang Jing Jin Zijing Liu Weihong Yang Yaoning Liu Yanwen Jin Kaitong Li Yongjiu Xiao Junli Liu Huailong Zhao Yue Liu Ping Li Jibo Song Lu Zhang Yuwei Gao Sisi Kang Shoudeng Chen Qingjun Ma Xiuwu Bian Wei Chen Xuan Liu Qing Mao Cheng Cao 
funded by the National Science and Technology Major Projects(2018ZX09711003-005-005 and 2018ZX09201017-007);the National Basic Research Program of China(2012CB518902).
Excessive inflammatory responses contribute to the pathogenesis and lethality of highly pathogenic human coronaviruses,but the underlying mechanism remains unclear.In this study,the N proteins of highly pathogenic hum...
关键词：LUNG INFLAMMATION activation 
Clinical factors associated with composition of lung microbiota and important taxa predicting clinical prognosis in patients with severe community-acquired pneumonia被引量：4
《Frontiers of Medicine》2022年第3期389-402,共14页Sisi Du Xiaojing Wu Binbin Li Yimin Wang Lianhan Shang Xu Huang Yudi Xia Donghao Yu Naicong Lu Zhibo Liu Chunlei Wang Xinmeng Liu Zhujia Xiong Xiaohui Zou Binghuai Lu Yingmei Liu Qingyuan Zhan Bin Cao 
funded by the National Key Research and Devclopment Program of China(No,2017YFC1309301);the CAMS Innovation Fund for Medical Sciences(CIFMS:No.2018-12M-1-003);the National Science Grant for Distinguished Young Scholars(No.81425001/H0104);the Ministry of Science and Technology of China No.2017ZX10103004).
Few studies have described the key features and prognostic roles of lung microbiota in patients with severe community-acquired pneumonia(SCAP).We prospectively enrolled consecutive SCAP patients admitted to ICU.Bronch...
关键词：severe community-acquired pneumonia lung microbiota clinical improvements 7-category ordinal scale Prevotellaceae 
Mesenchymal stem cell therapy for severe COVID-19被引量：7
《Signal Transduction and Targeted Therapy》2021年第10期2945-2949,共5页Lei Shi Lifeng Wang Ruonan Xu Chao Zhang Yunbo Xie Kai Liu Tiantian Li Wei Hu Cheng Zhen Fu-Sheng Wang 
supported by the The National Key R&D Program of China(2020YFC08860900);National Science and Technology Major Project of the Ministry of Science and Technology of China(2017ZX10202102-004-002).
The coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has placed a global public burden on health authorities.Although the virological characteristics and pathoge...
关键词：ACUTE LUNG clarified 
In vivo self-assembled small RNAs as a new generation of RNAi therapeutics被引量：14
《Cell Research》2021年第6期631-648,共18页Zheng Fu Xiang Zhang Xinyan Zhou Uzair Ur-Rehman Mengchao Yu Hongwei Liang Hongyuan Guo Xu Guo Yan Kong Yuanyuan Su Yangyang Ye Xiuting Hu Wei Cheng Jinrong Wu Yanbo Wang Yayun Gu Sheng-feng Lu Dianqing Wu Ke Zen Jing Li Chao Yan Chen-Yu Zhang Xi Chen 
supported by grants from the National Basic Research Program of China(973 Program)(2014CB542300);the National Natural Science Foundation of China(32022015,32001077,31871295 and 21877060);the Natural Science Foundation of Jiangsu Province(BE2016737);the Fundamental Research Funds for the Central Universities(020814380125,020814380130,020814380133 and 020814380146);supported by a research grant from the State Key Laboratory of Reproductive Medicine(SKLRM-K201801).
RNAi therapy has undergone two stages of development,direct injection of synthetic siRNAs and delivery with artificial vehicles or conjugated ligands;both have not solved the problem of efficient in vivo siRNA deliver...
关键词：VIVO LUNG gramme 
Application of germ-free NOD-scid IL2rg^(null)mice as a humanized model for tumor microbiome precision medicine
《Science China(Life Sciences)》2021年第4期644-647,共4页Chengwei Wu Haitao Shang Xianhong Jiang Xinning Wang Hong Wei 
supported by grants from the National Key Research and Development Program of China(2017YFD0500503,2017YFD0501000);the National Natural Science Foundation of China(81770434,81370906);the National Program on Key Basic Research Project of China(973 Program)(2007CB513007,2013CB531406)。
In 2013,tumor immunotherapy topped the list of the top ten scientific breakthroughs(Couzin-Frankel,2013),and it was widely used in the treatment of lung cancer,kidney cancer,and melanoma(Routy et al.,2018).However,the...
关键词：al. LUNG cancer 
Phage capsid nanoparticles as multivalent inhibitors of viral infections
《Science Bulletin》2020年第24期2050-2052,M0004,共4页Manzar Abbas Muhammad Ovais Chunying Chen 
financial support from the European Union’s Horizon 2020 program under grant 839177 (PEPREP);financial support from the Ministry of Science and Technology of China (2016YFA0201600, 2016YFE0133100);the Science Fund for Creative Research Groups of the National Natural Science Foundation of China (11621505)。
In the present time, coronavirus disease COVID-19 has become prevalent across the globe and declared as a pandemic by the world health organization(WHO) [1]. As of now, many vaccines and medicines are in the approval ...
关键词：病毒感染 衣壳 LUNG 
The deubiquitylase UCHL3 maintains cancer stem-like properties by stabilizing the aryl hydrocarbon receptor被引量：3
《Signal Transduction and Targeted Therapy》2020年第1期1609-1622,共14页Lianlian Ouyang Bin Yan Yating Liu Chao Mao Min Wang Na Liu Zuli Wang Shouping Liu Ying Shi Ling Chen Xiang Wang Yan Cheng Ya Cao Desheng Xiao Lingqiang Zhang Shuang Liu Yongguang Tao 
The National Natural Science Foundation of China(81672991 and 81874139[S.L.],81672787[Y.T.],81672308[X.W.]);the National Basic Research Program of China(2015CB553903[Y.T.])supported this study.
Cancer stem cells(CSCs)exhibit highly aggressive and metastatic features and resistance to chemotherapy and radiotherapy.Aryl hydrocarbon receptor(AhR)expression varies among non-small cell lung cancers(NSCLCs),and th...
关键词：LUNG markedly CHEMOTHERAPY 
Rab22a-NeoF1:a promising target for osteosarcoma patients with lung metastasis
《Signal Transduction and Targeted Therapy》2020年第1期1074-1075,共2页Kai Xie Xinyi Zhang Yongguang Tao 
supported by the National Natural Science Foundation of China(81672787,Y.T.);the National Basic Research Program of China(2015CB553903,Y.T.);the Key Area R&D Program of the Hunan Province in China(2019SK2253,Y.T.)。
Osteosarcoma is the most common primary malignant bone tumor among adolescents and children,with high level of lung metastasis and poor prognosis.The treatment of metastatic cases remains a challenge in the clinic,lea...
关键词：METASTASIS OSTEOSARCOMA LUNG 
Automatic Detection of Lung Nodules Using 3D Deep Convolutional Neural Networks被引量：2
《Journal of Shanghai Jiaotong university(Science)》2019年第4期517-523,共7页FU Ling MA Jingchen CHEN Yizhi LARSSON Rasmus ZHAO Jun 
the National Natural Science Foundation of China(No.81371624);the National Key Research and Development Program of China(No.2016YFC0104608);the National Basic Research Program of China(No.2010CB834302);the Shanghai Jiao Tong University Medical Engineering Cross Research Funds(Nos.YG2013MS30 and YG2014ZD05)
Lung cancer is the leading cause of cancer deaths worldwide. Accurate early diagnosis is critical in increasing the 5-year survival rate of lung cancer, so the efficient and accurate detection of lung nodules,the pote...
关键词：LUNG NODULE DETECTION COMPUTER-AIDED DETECTION (CAD) convolutional NEURAL NETWORK (CNN) fully convolutional NEURAL NETWORK (FCN) 
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