LUNG

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  • 期刊=Signal Transduction and Targeted Therapyx
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Integration of novel biomarkers in prospective trials: biological insights from CHOICE-01
《Signal Transduction and Targeted Therapy》2025年第1期3-4,共2页Edward Christopher Dee Puneeth Iyengar 
The recent publication of the CHOICE-01 study,reporting overall survival(OS)and published in Signal Transduction and Targeted Therapy,1 recapitulated findings from an earlier publication of the trial.2 The CHOICE-01 i...
关键词：PROSPECTIVE CHEMOTHERAPY LUNG 
Mechanism exploration and model construction for small cell transformation in EGFR-mutant lung adenocarcinomas
《Signal Transduction and Targeted Therapy》2024年第11期5144-5156,共13页Yan Li Tongji Xie Shouzheng Wang Lin Yang Xuezhi Hao Yan Wang Xingsheng Hu Lin Wang Junling Li Jianming Ying Puyuan Xing 
the National Natural Science Foundation of China(No.82172876);CAMS Innovation Fund for Medical Sciences(No.2021-1-I2M-012);Beijing Hope Run Special Fund of Cancer Foundation of the People’s Republic of China(LC2019L04,LC2022A20).
Small-cell lung cancer(SCLC)transformation accounts for 3-14%of resistance in EGFR-TKI relapsed lung adenocarcinomas(LUADs),with unknown molecular mechanisms and optimal treatment strategies.We performed transcriptomi...
关键词：LUNG ADENOCARCINOMA PREVENTION 
A breath of fresh air:targeted non-viral in vivo gene correction in the mammalian lung
《Signal Transduction and Targeted Therapy》2024年第11期4771-4772,共2页Jixin Liu Dirk Grimm 
D.G.appreciates support by the German Research Foundation(DFG)through the DFG Collaborative Research Centers SFB1129(Projektnummer 240245660);TRR179(Projektnummer 272983813).
In a recent study published in Science,1 Sun and colleagues showcase the power and potential of lung SORT LNPs,i.e.,lipid nanoparticles that upon systemic delivery in mice specifically and efficiently target cells in ...
关键词：LUNG CORRECTION EDITOR 
Biofilms and exopolysaccharides in Pseudomonas aeruginosa:pathogenesis,immune evasion,and lung–brain signaling during pneumonia
《Signal Transduction and Targeted Therapy》2024年第9期3550-3551,共2页Shuaibing Zhang Pierre Stallforth 
supported by Deutsche Forschungsgemeinschaft(German Research Foundation)under Germany’s Excellence Strategy EXC 2051(Project-ID 390713860,“Balance of the Microverse”);-SFB1127/2 ChemBioSys—Project ID 239748522;the Werner Siemens Foundation.
A recent study by Granton et al.in Cell investigates the role of exopolysaccharide(EPS)in Pseudomonas aeruginosa’s biofilm formation,immune evasion,and lung–brain signaling during pneumonia.1 This research significa...
关键词：PNEUMONIA LUNG 
CDC7 inhibition impairs neuroendocrine transformation in lung and prostate tumors through MYC degradation
《Signal Transduction and Targeted Therapy》2024年第8期3519-3532,共14页Alvaro Quintanal-Villalonga Kenta Kawasaki Esther Redin Fathema Uddin Swanand Rakhade Vidushi Durani Amin Sabet Moniquetta Shafer Wouter R.Karthaus Samir Zaidi Yingqian A.Zhan Parvathy Manoj Harsha Sridhar Dennis Kinyua Hong Zhong Barbara P.Mello Metamia Ciampricotti Umesh K.Bhanot Irina Linkov Juan Qiu Radhika A.Patel Colm Morrsey Sanjoy Mehta Jesse Barnes Michael C.Haffner Nichlas D.Socci Richard P.Koche Elisa de Stanchina Sonia Molina-Pinelo Sohrab Salehi Helena A.Yu Joseph M.Chan Charles M.Rudin 
This study was supported by PO1 NIH PO1CA163227(Prostate Cancer Donor Program),NIH T32 CA1600001(to A.Q.V.),NCI R01 CA264078(to C.M.R.and,H.A.Y.);The Doris Duke Foundation(Grant 2021184)(to MCH),NCI P50 CA97186(to M.H.and C.M.),NCI R35 CA263816(to C.M.R.),NCI U24 CA213274(to C.M.R.),Yasuda Medical Foundation(to K.K.);the American Lung Association(to A.Q.V.);the Druckenmiller Center for Lung Cancer Research(to A.Q.V.,K.K.,and C.M.R.);This study was also supported by the Regional Ministry of Health and Consume of Andalucia RC-0004-2020(SMP);the Carlos II Health Institute through the projects"PI20/01109 and PI23/01679"(Co-funded by European Regional Development Fund/European Social Fund;"A way to make Europe""nvesting in your future")(SMP).
Neuroendocrine(NE)transformation is a mechanism of resistance to targeted therapy in lung and prostate adenocarcinomas leading to poor prognosis.Up to date,even if patients at high risk of transformation can be identi...
关键词：TUMORS markedly TRANSFORMATION 
Cellular precision modulation of JAK1:tailoring therapies for allergic lung inflammation
《Signal Transduction and Targeted Therapy》2024年第7期2843-2844,共2页Xiaocheng Yan Siegfried Ussar 
X.Y.received support from China Scholarship Council(No.201908370218).
In a recent publication published in Cell,Tamari et al.unraveled a previously unrecognized role of JAK1 signaling in vagal sensory neurons regulating the immune response to allergic lung inflammation.1 The authors sho...
关键词：JAK1 ALLERGIC LUNG 
Correction:Anti-lymphangiogenesis for boosting drug accumulation in tumors被引量：1
《Signal Transduction and Targeted Therapy》2024年第7期3141-3142,共2页Chunling Wang Junchao Xu Xiaoyu Cheng Ge Sun Fenfen Li Guangjun Nie Yinlong Zhang 
Correction to:Signal Transduction and Targeted Therapy https://doi.org/10.1038/s41392-024-01794-4,published online 15 April 2024 After the article was published online,1 the authors noticed one inadvertent mistake in ...
关键词：LUNG BOOSTING repeatedly 
Diabetes and pulmonary infection:how hyperglycaemia shapes the immune system被引量：2
《Signal Transduction and Targeted Therapy》2024年第4期1245-1246,共2页Christian Herder Michael Roden Nicolas Venteclef 
supported by a grant from Horizon Europe (INTERCEPT-T2D,101095433);supported by the German Diabetes Center (DDZ),which is funded by the German Federal Ministry of Health (Berlin,Germany);the Ministry of Culture and Science of the state North Rhine-Westphalia (Düsseldorf,Germany);receives additional funding from the German Federal Ministry of Education and Research (BMBF)through the German Center for Diabetes Research (DZD e.V.).
In a recent study published in Nature,Nobs and colleagues aimed to identify novel mechanisms that may explain why diabetes is associated with an increased susceptibility to viral respiratory infections.Their analyses ...
关键词：IMPAIRED LUNG RESPIRATORY 
Lung microbiome:new insights into the pathogenesis of respiratory diseases被引量：5
《Signal Transduction and Targeted Therapy》2024年第2期652-678,共27页Ruomeng Li Jing Li Xikun Zhou 
supported by the National Natural Science Foundation of China(No.82241049,81922042,82072999,82172285 and 82273320);the 1·3·5 Project of Excellent Development of Discipline of West China Hospital of Sichuan University(No.ZYYC21001);the“Zero to One”Innovation Research Project of Sichuan University(No.2022SCUH0029).
The lungs were long thought to be sterile until technical advances uncovered the presence of the lung microbial community.The microbiome of healthy lungs is mainly derived from the upper respiratory tract(URT)microbio...
关键词：RESPIRATORY DISEASES LUNG 
Targeting complement hyperactivation:a novel therapeutic approach for severe pneumonia induced by influenza virus/staphylococcus aureus coinfection
《Signal Transduction and Targeted Therapy》2024年第1期51-54,共4页Leili Jia Haihua Luo Lizhong Li Mingyao Wang Jiangfeng Liu Yuan Liang Shan Li Yong Jiang Juntao Yang Hongbin Song 
supported by grants from the National Key Research and Development Program of China(Nos.2018YFC1200100,2016YFC1200905);National Key Technology R&D Program of China(No.2017ZX10104001);National Natural Science Foundation of China(Nos.30801004,81371807);NSFC-Guangdong Joint Foundation of China(No.U1601225);Beijing Municipal Natural Science Foundation(No.7122132);the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2021-I2M-1-044);the National College Students Innovation and Entrepreneurship Training Program of China(No.2023zglc06011).
Dear Editor,Infections by the influenza virus are a significant and widespread global health threat,as these infections have an annual death toll ranging from 290,000 to 650,000.1 A significant proportion of these fat...
关键词：INFLUENZA PNEUMONIA LUNG 
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