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Adaptive neoadjuvant endocrine therapy screens out prime population of ribociclib intensive adjuvant therapy: 《Chinese Journal of Cancer Research》2025年第1期115-117,共3页Zhao Bi Tongyue Ren Yongsheng Wang; supported by China Postdoctoral Science Foundation(No.2022M721987);Natural Science Foundation of Shandong Province(No.ZR2024QH058).; The latest data from the NATALEE trial showed the absolute 3-year invasive disease-free survival benefit was 4.9%between the experimental and control groups.That is to say,in the intermediate-risk hormone receptor pos...; 关键词：Breast cancer Ribociclib hormone receptor positive/human epidermal growth factor receptor-2 negative subgroup neoadjuvant endocrine therapy

PICTURE WINDOW HOUSE: 《城市环境设计》2025年第1期87-88,共2页Shigeru Ban Nobutaka Hiraga Anne Scheou Tomoo Nitta Soichiro Hiyoshi 无 Hiroyuki Hirai(Photography); Transparency in Architecture.I am deeply fond of the architecture of Mies van der Rohe.His design of the Farnsworth House(1951)stands as a groundbreaking work in Western architectural history,marking the first time a ...; 关键词：farnsworth house stands Mies van der Rohe Farnsworth House TRANSPARENCY opening fusuma shoji screens fusuma shoji screens architecture

Genome-wide CRISPR screens identify CLC-2 as a drug target for anti-herpesvirus therapy:tackling herpesvirus drug resistance: 《Science China(Life Sciences)》2025年第2期515-526,共12页Fayu Yang Nan Wei Shuo Cai Jing Liu Qingping Lan Hao Zhang Lu Shang Bo Zheng Mi Wang Yingchun Liu Lifang Zhang Chenzhong Fei Wu Tong Changlong Liu Ersheng Kuang Guangzhi Tong Feng Gu; supported by the National Natural Science Foundation of China(32071443);China Postdoctoral Science Foundation(2023M731465);the Natural Science Foundation of Gansu province(23JRRA1134)。; The emergence of drug resistance to virus(i.e.,acyclovir(ACV)to herpesviruses)has been termed one of the common clinical issues,emphasizing the discovery of new antiviral agents.To address it,a genome-wide clustered r...; 关键词：HERPESVIRUSES CRISPR host-directed therapy CLC-2 DIDS

Percutaneous Penetration and Dermal Exposure Risk Assessment of UV Absorbents in Sunscreens and Isolation Cosmetics: 《Environment & Health》2024年第8期541-552,共12页Lu Bai Juan Li Binbin Guo Ruitong Cai Chunyan Zhao Yanli Guo Yawei Wang Guibin Jiang; We gratefully acknowledge the financial support from the National Natural Science Foundation of China(22136006,22021003,and 22106169);Strategic Priority Research Program of the Chinese Academy of Sciences,Grant XDB0750000.; Ultraviolet absorbents(UVs)make up a group of industrial chemicals that is used in various consumer products and industrial applications.Due to their extensive production and usage,UVs have been detected in multiple e...; 关键词：ultraviolet absorbents SUNSCREEN dermal exposure dermal penetration risk assessment

Genome-wide CRISPR screens identify PTPN21 and WDR26 as modulators of the mitochondrial stress-induced ISR: 《Life Metabolism》2024年第4期55-61,共7页Wen Li Mingyue Dong Kaiyu Gao Jialiang Guan Ying Liu; supported by the National Natural Science Foundation of China(32293212,92254305,and 31925012);the HHMI International Research Scholar Program(55008739)to Y.L.Y.L.was also supported by the Peking-Tsinghua Center for Life Sciences,Beijing Advanced Innovation Center for Genomics,and the Tencent Foundation through the XPLORER PRIZE.; Dear Editor,Organisms have evolved mitochondrial stress response pathways to surveil mitochondrial function and activate repair programs upon detection of mitochondrial dysfunction[1].Failure to respond to mitochondri...; 关键词：stress DISEASES primarily

Decoding γδ T cell anticancer therapies: integrating CRISPR screens with tumor organoids: 《Signal Transduction and Targeted Therapy》2023年第12期5572-5574,共3页Jian Zhou Min Wu Gen Yang; support from research grants provided by the National Natural Science Foundation of China(12375334);the National Key Research and Development Program of China(Grant No.2022YFD1201600);the Key Program of Wenzhou Institute,University of Chinese Academy of Sciences(WIUCASQD2021015).; In a recent publication in Nature,1 Mamedov and colleagues identified pathways that modulateγδT cell killing and BTN3A cellular expression through integrating genome-wide CRISPR screens and tumor organoid culture,de...; 关键词：integrating DEEPENING culture

Discovery of target genes and pathways at GWAS loci by pooled single-cell CRISPR screens: 《四川生理科学杂志》2023年第8期1520-1520,共1页John A Morris; Most variants associated with complex traits and diseases identified by genome-wide association studies(GWAS)map to noncoding regions of the genome with unknown effects.Using ancestrally diverse,biobank-scale GWAS dat...; 关键词：GWAS TRAITS massive

Bioinformatics approaches to analyzing CRISPR screen data:from dropout screens to single-cell CRISPR screens: 《Quantitative Biology》2022年第4期307-320,共14页Yueshan Zhao Min Zhang Da Yang; This study was supported by the Shear Family Foundation(to D.Y.),the American Cancer Society Research Scholar Award(132632-RSG-18-179-01-RMC to D.Y.);National Cancer Institute(1R01CA222274 and R01CA255196 to D.Y.).; Background:Pooled CRISPR screen is a promising tool in drug targets or essential genes identification with the utilization of three different systems including CRISPR knockout(CRISPRko),CRISPR interference(CRISPRi)and...; 关键词：CRISPR/Cas9 dropout screen sorting-based screen single-cell CRISPR screen drug-gene interaction

The beginning of a new era:pioneering direct screens for RNA modulators: 《Signal Transduction and Targeted Therapy》2022年第8期2660-2661,共2页F.X.Reymond Sutandy Rebecca George Tharyan Christian Münch; supported by grants from the European Research Council(ERC StG 803565);the Deutsche Forschungsgemeinschaft(DFG,German Research Foundation)Project-ID 390339347(Emmy Noether Programme);the EnABLE consortium funded by the Hessian Ministry for Arts and Sciences.; In a recent study published in Nature,1 Aguilar et al.describe the small molecule X1 that targets the long non-coding RNA Xist.Upon X1 binding,Xist changes its structure,which prevents its role in X-chromosome inactiv...; 关键词：DRUGS SCREEN currently

Young People Spend So Long Staring At Screens Half May Need Glasses In 30 Years: 《语数外学习（高中版）（上）》2021年第11期90-91,共2页胡坤鹏; 没事就把手机、平板拿出来看看,已成为现代人的常态。电子设备极大地方便了我们的生活。但同时过度使用电子设备带来的危害也不容忽视。科学家称,手机和电脑屏幕是儿童和年轻人近视风险上升的罪魁祸首。预计到2050年,世界上一半人可能...; 关键词：电子设备电脑屏幕过度使用手机近视

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