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Up-Regulation of Trem2 Inhibits Hippocampal Neuronal Apoptosis and Alleviates Oxidative Stress in Epilepsy via the PI3K/Akt Pathway in Mice被引量：33
《Neuroscience Bulletin》2019年第3期471-485,共15页Ai-Hua Liu Min Chu Yu-Ping Wang 
supported by Beijing Key Laboratory of Neuromodulation(BZ0098);the Precision Medicine Project of the Ministry of Science and Technology of China(2016YFC0904400)
Epilepsy is a chronic and severe neurological disorder that has negative effects on the autonomous activities of patients. Functionally, Trem2(triggering receptor expressed on myeloid cells-2) is an immunoglobulin rec...
关键词：Trem2 EPILEPSY NEURONAL apoptosis PI3K/Akt pathway OXIDATIVE stress 
PML contributes to p53-independent p21 up-regulation in gamma-irradiation induced DNA damage responses被引量：1
《Chinese Science Bulletin》2011年第30期3148-3154,共7页CAO Lin SONG Yi TIAN BaoLei LIU JiLai LIU Bin ZHANG JiaNing SUN ZhiXian 
supported by the National Basic Research Program of China (2007CB914604);the National Natural Science Foundation of China (30900276, 30970683, 30600162)
The cyclin-dependent kinase inhibitor p21 WAF1/Cip1 is a critical cell cycle regulator which translocates into the nucleus to participate in DNA repair during DNA damage responses. In the present study, we showed that...
关键词：DNA损伤 Γ射线照射 PML P21 P53 反应 增殖细胞核抗原 细胞周期蛋白 
Up-Regulation of CCR5 and CXCR4 Expression on Human Monocytes by Interferon Gamma
《Tsinghua Science and Technology》2003年第4期440-444,共5页陆韵 刘祖强 陈应华 
Supported by the National Key Basic Research Specific Funds (No. G19990 75 6 0 7) and the National ScienceFoundation for Outstanding Young Scientist of China(No. 30 0 2 5 0 38)
Chemokine receptors, mainly CCR5 and CXCR4, have been proved to be the important coreceptors in HIV 1 entry. HIV 1 disease progression is, in general, characterized by an initial predominance of CCR5 using macrop...
关键词：HIV  1 IFN  γ chemokine receptor CXCR4 CCR5 
Lipopolysaccharide upregulates the expression of Toll-like receptor 4 in human vascular endothelial cells被引量：1
《Chinese Medical Journal》2002年第2期286-289,158,共4页杨清武 朱佩芳 王正国 蒋建新 
theMajorStateBasicResearchDevelopmentProgramofChina (No G19990 5 42 0 3)
OBJECTIVE: To investigate the expression of Toll-like receptor 2 (TLR2) and Toll-like receptor 4 (TLR4) and the effect of lipopolysaccharide (LPS) on their expression in cultured endothelial cells. METHODS: Total RNA ...
关键词：Drosophila Proteins Cell Line Dose-Response Relationship  Drug Endothelium  Vascular Gene Expression Regulation Humans LIPOPOLYSACCHARIDES Membrane Glycoproteins RNA  Messenger Receptors  Cell Surface Research Support  Non-U.S. Gov't Time Factors Toll-Like Receptor 2 Toll-Like Receptor 4 Toll-Like Receptors Umbilical Veins UP-REGULATION 
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