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Up-regulation of oxidative stress and inflammation in the brain of albino wistar rats following sub-acute administration of Synclisia scabrida root extract
《TMR Integrative Medicine》2022年第30期1-7,共7页Emmanuel Uchechukwu Modo Ijeoma Nina Eke Utibe Evans Bassey Anthony Chibuzor Nnamudi Ekam Ime Akpakpan Okon Effiom Etim Iheanyichukwu Wopara Prosper Great Legborsi 
Objective: Synclisia scabrida is a medicinal plant used over the years for the treatment ofseveral medical conditions yet there is paucity of information on its systemic and organspecific toxicity. Consequently, sub-a...
关键词：Synclisia scabrida oxidative stress antioxidant INFLAMMATION NEUROTOXICITY 
Piperlongumine Inhibits Zika Virus Replication In vitro and Promotes Up-Regulation of HO-1 Expression, Suggesting An Implication of Oxidative Stress被引量：5
《Virologica Sinica》2021年第3期510-520,共11页Weizhi Lu Linjuan Shi Jing Gao Huimin Zhu Ying Hua Jintai Cai Xianbo Wu Chengsong Wan Wei Zhao Bao Zhang 
supported by the National Natural Science Foundation (Nos. 31670168, 31470271 and 81730110);National Key R&D Program of China (Grant No. 2018YFC1602206);Guangdong Provincial Science and Technology (No. 2018B020207006)。
Owing to the widespread distribution of mosquitoes capable of transmitting Zika virus, lack of clinical vaccines and treatments, and poor immunity of populations to new infectious diseases, Zika virus has become a glo...
关键词：Piperlongumine Heme oxygenase-1(HO-1) Reactive oxygen species Zika virus(ZIKV) Human brain microvascular endothelial cells 
Up-regulation of Thioredoxin 1 by aerobic exercise training attenuates endoplasmic reticulum stress and cardiomyocyte apoptosis following myocardial infarction被引量：2
《Sports Medicine and Health Science》2020年第3期132-140,共9页Mengxin Cai Zujie Xu Wenyan Bo Fangnan Wu Wenpu Qi Zhenjun Tian 
supported by National Natural Science Foundation of China(Grant No.31701039,31671240);the Fundamental Research Funds for the Central Universities,Shaanxi Normal University(Grant Number GK201803096).
Exercise training(ET)has been reported to reduce oxidative stress and endoplasmic reticulum(ER)stress in the heart following myocardial infarction(MI).Thioredoxin 1(Trx1)plays a protective role in the infarcted heart....
关键词：Endoplasmic reticulum stress Myocardial infarction Exercise training Thioredoxin 1 Oxidative stress 
Up-regulation of miR-139-5p protects diabetic mice from liver tissue damage and oxidative stress through inhibiting Notch signaling pathway被引量：3
《Acta Biochimica et Biophysica Sinica》2020年第4期390-400,共11页Hua Wei Liwei Huang Fenghua Wei Guangzhi Li Bin Huang Jun Li Cong Cao 
the grant from the First Batch of High-level Talent Scientific Research Projects of the Affiliated Hospital of Youjiang Medical University for Nationalities in 2019(No.R20196314).
The occurrence and development of diabetes seriously threaten the health of patients.Therefore,the mechanism exploration of diabetes is of great significance for more effective control of this disease.In this study,we...
关键词：miR-139-5p Notch signaling pathway DIABETES oxidative stress 
Up-Regulation of Trem2 Inhibits Hippocampal Neuronal Apoptosis and Alleviates Oxidative Stress in Epilepsy via the PI3K/Akt Pathway in Mice被引量：34
《Neuroscience Bulletin》2019年第3期471-485,共15页Ai-Hua Liu Min Chu Yu-Ping Wang 
supported by Beijing Key Laboratory of Neuromodulation(BZ0098);the Precision Medicine Project of the Ministry of Science and Technology of China(2016YFC0904400)
Epilepsy is a chronic and severe neurological disorder that has negative effects on the autonomous activities of patients. Functionally, Trem2(triggering receptor expressed on myeloid cells-2) is an immunoglobulin rec...
关键词：Trem2 EPILEPSY NEURONAL apoptosis PI3K/Akt pathway OXIDATIVE stress 
Up-regulation of mitochondrial chaperone TRAP1 in ulcerative colitis associated colorectal cancer被引量：9
《World Journal of Gastroenterology》2014年第45期17037-17048,共12页Ru Chen Sheng Pan Keith Lai Lisa A Lai David A Crispin Mary P Bronner Teresa A Brentnall 
Supported by Grants from National Institutes of Health,No.R21CA164548;from Crohn’s and Colitis Foundation of America
AIM: To characterize tumor necrosis factor receptor-associated protein 1 (TRAP1) expression in the progression of ulcerative colitis (UC)-associated colorectal cancer.
关键词：Ulcerative colitis Colorectal cancer Inflammation Oxidative stress Tumor necrosis factor receptor-associated protein 1 
Up-regulation of divalent metal transporter 1 in 6-hydroxydopamine intoxication is IRE/IRP dependent被引量：26
《Cell Research》2010年第3期345-356,共12页Hong Jiang Ning Song Huamin Xu Shuzhen Zhang Jun Wang Junxia Xie 
We thank Dr Wei-dong Le for providing the MES23.5 cell line. This work was supported by grants from the National Program of Basic Research sponsored by the Ministry of Science and Tech- nology of China （2006CB500704）, the National Natural Science Foundation of China （30930036, 30770757, 30870858） and the Natural Science Fund of Shandong Province for Distinguished Young Scholars （JQ200807）.
Iron plays a key role in Parkinson＇s disease （PD）. Increased iron content of the substantia nigra （SN） has been found in PD patients, and divalent metal transporter 1 （DMT1） has been shown to be up-regulated in...
关键词：divalent metal transporter 1 iron iron regulatory protein Parkinson＇s disease oxidative stress ANTIOXIDANT 
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