BACKGROUND Colorectal cancer is a frequent cause of cancer-related mortality in patients with lymph node or distant metastases.Pericolonic tumor deposits(TDs)are considered prognostically distinct from lymph node meta...
Supported by Ministry of Health of the Czech Republic,No. NV18-09-00493 and No. NU21J-06-00027
Advances in diagnostics of inflammatory bowel diseases(IBD)and improved treatment strategies allowed the establishment of new therapeutic endpoints.Currently,it is desirable not only to cease clinical symptoms,but mai...
BACKGROUND Microscopic colitis is a leading cause of diarrhea in the older adults.There is limited information about risk factors.We hypothesized that obesity would be associated with microscopic colitis.AIM To examin...
Ulcerative colitis(UC)is a chronic,nonspecific,relapsing inflammatory bowel disease.The colorectum is considered the chief target organ of UC,whereas upper gastrointestinal(UGI)tract manifestations are infrequent.Rece...
Supported by Fondo de Investigación Sanitaria,Instituto de Salud Carlos III,Subdirección General de Investigación Sanitaria,Ministerio de Economía y Competitividad,CP10/00502,PI13/00935 and CIBERehd,CB06/04/0021(MV)
Microscopic colitis(MC) is a chronic inflammatory bowel disease that has emerged in the last three decades as a leading cause of chronic watery diarrhoea. MC classically includes two main subtypes: lymphocytic colitis...
AIM To evaluate mucosal baseline m RNA expression of tissue transglutaminase 2(t TG2), interferon gamma(IFNγ), toll-like receptor 2(TLR2) and Myeloid Differentiation factor 88(MyD 88) in patients with microscopic ent...
Microscopic enteritis(ME) is an inflammatory condition of the small bowel that leads to gastrointestinal symptoms,nutrient and micronutrient deficiency.It is characterised by microscopic or sub-microscopic abnormaliti...
Classic polyarteritis nodosa(PAN) that targets mediumsized muscular arteries and microscopic polyangiitis(MPA),characterized by inflammation of small-caliber vessels and the presence of circulating myeloperoxidase ant...
Research Committee of Orebro County Council;Sezin Gunaltay's salary is covered by a grant from Orebro University
AIM:To investigate Toll-like receptor(TLR)signaling regulators in microscopic and ulcerative colitis patients.METHODS:Total RNA and microRNA were isolated from fresh frozen colonic biopsies of non-inflamed controls an...
The risk of developing dysplasia leading to colorectal cancer (CRC) is increased in both ulcerative colitis and Crohn’s disease. The prognosis of CRC may be poorer in patients with inflammatory bowel disease (...