HAPTEN

作品数：24被引量：54H指数：4
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相关领域：医药卫生农业科学更多>>
相关作者：张笑天韩雅郭宁宁陈世忠王弘更多>>
相关机构：北京大学更多>>
相关期刊：《Chemical Research in Chinese Universities》《Science Bulletin》《Journal of Chinese Pharmaceutical Sciences》《Cellular & Molecular Immunology》更多>>
相关基金：国家自然科学基金国家高技术研究发展计划中国博士后科学基金北京市自然科学基金更多>>
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Development of ic-ELISA and colloidal cold-based immunochromatographic assay for red 2G detection in fruit drinks, red wine, and yoghurts
《Food Bioscience》2023年第2期865-871,共7页Xiaoling Li Xinxin Xu Lingling Guo Shanshan Song Liqiang Liu Yingyue Zhu Hua Kuang Chuanlai Xu Liguang Xu 
This work was funded by the National Key R&D Program(2019YFC1604602);grants from Science and Technology Program of Jiangsu Market Supervision and Administration Bureau(KJ21125093);This work was also supported by the Fundamental Research Funds for the Central Universities(JUSRP622012).
Red 2G(R2G),a cheap industrial colorant,cannot be added to food.An anti-R2G monoclonal antibody(mAb)was prepared by immunizing mice with the conjugate of R2G hapten and protein,which based on the 1-ethyl-3-(3-dimethyl...
关键词：Monoclonal antibody Red 2G Ic-ELISA HAPTEN Colloidal gold-based immunochromatographic assay 
Rational hapten design and establishment of broad-spectrum indirect competitive enzyme-linked immunosorbent assay for benzimidazoles monitoring in milk
《Food Quality and Safety》2023年第1期152-166,共15页王梓乐 张亮 杨艳红 张会霞 张维春柏 郑丕苗 江海洋 
the Ministry of Science and Technology of the People's Republic of China(No.2020YFF01014605).
Objectives Benzimidazoles(BZs)are commonly used for the treatment of soil-transmitted helminth infections in veterinary clinics;however,misuse and overdosing of BZs will cause residual problems and have the potential ...
关键词：BENZIMIDAZOLES novel hapten broad-spectrum antibody IMMUNOASSAY quantitative structure-activity relationship MILK MONITORING 
Synthesis of haptens and production of antibodies to bisphenol A
《Frontiers of Agricultural Science and Engineering》2017年第3期366-372,共7页Xiya ZHANG Xiaoyun DONG Sijun ZHAO Yuebin KE Kai WEN Suxia ZHANG Zhanhui WANG Jianzhong SHEN 
supported by the National Natural Science Foundation of China (31622057)
Three immunizing haptens of bisphenol A(BPA), including two new haptens, were used to produce highly sensitive and specific polyclonal antibodies. The spacer arms of haptens for coupling to the protein carrier were lo...
关键词：bisphenol A CROSS-REACTIVITY HAPTEN indirect competitive ELISA polyclonal antibody 
Analysis on molecular interaction mechanism of four hapten flavonoids in Shuang-huang-lian powder injection with bovine serum albumin被引量：2
《Journal of Chinese Pharmaceutical Sciences》2017年第5期366-371,共6页江海秀 管颜青 张笑天 韩雅 郭宁宁 王弘 陈世忠 
Nature Science Foundation of Beijing,China(Grant No.7142088)
Baicalein, baicalin, scutellarin and Chrysin-7-O-β-D-glucuronide are the major flavonoids of the Shuang-huang-lian powder injection. These flavonoids are thought to be haptens that can induce allergic reactions. The ...
关键词：Hapten flavonoids SPR Molecular modeling BSA Interaction 
Staphylococcal enterotoxin B-derived haptens promote sensitization被引量：1
《Cellular & Molecular Immunology》2013年第1期78-83,共6页Shao-Bo Yang Tong-Li Li Xiao Chen Yun-Fang An Chang-Qing Zhao Jun-BaoWen Dao-Fa Tian Zhong Wen Min-Qiang Xie Ping-Chang Yan 
T helper 2 （Th2） polarization is a major pathological feature in allergic diseases; its etiology is not fully understood. This study aims to elucidate the adjuvant effect of the microbial product-derived small pepti...
关键词：INTESTINE food allergy HAPTEN microbial products IMMUNIZATION 
Synthesis and characteristics of a novel artificial hapten using the copper mercaptide of penicillenic acid from penicillin G for immunoassay of heavy metal ions被引量：5
《Science China(Life Sciences)》2011年第9期813-821,共9页XU Wu XIE Peng FAN LiuYin CAO ChengXi XI Tao ZHOU Pei 
supported by the National Natural Science Foundation of China (Grant No. 30821005);National High Technology Research and Development Program of China (Grant No. 2007AA10Z401)
In this paper, we describe the synthesis of a novel copper ion hapten using the copper mercaptide of penicillenic acid （CMPA） derived from penicillin. Results from tests with immune rabbits indicate that： （i） A n...
关键词：IMMUNOASSAY copper ion HAPTEN ENVIRONMENT food sample 
Preparation of hapten-specific monoclonal antibody for cadmium and its ELISA application to aqueous samples被引量：4
《Frontiers of Environmental Science & Engineering》2011年第3期409-416,共8页Huan HE Bo TANG Cheng SUN Shaogui YANG Weijuan ZHENG Zichun HUA 
This work was supported by the National High Technology Research and Development Program of China(No.2006AA06Z411);China Postdoctoral Science Foundation(No.20100471297);Jiangsu Planned Projects for Postdoctoral Research Funds(No.0902065C).
High-affinity and specific monoclonal antibodies against cadmium-ethylene diamine tetraacetic acid(EDTA)complex have been produced using the hybridoma technique.A hapten was synthesized and characterized by Fourier Tr...
关键词：CADMIUM HAPTEN monoclonal antibody enzyme-linked immunosorbent assay(ELISA) 
Syntheses of haptens and hapten-protein conjugates for insecticide propoxur and cyhalothrin被引量：3
《Science China Chemistry》2010年第5期1107-1112,共6页Sang, GuangMing  Luo, ShiNeng  Lin, JianGuo  Qiu, Ling  Chen, ChuanQing  Yang, HaiLin  Xia, YongMei 
supported by the National High Technology Research and Development Program of China(2006AA10Z449);the National Natural Science Foundation of China(20801024);Wu Jieping Medical Foundation(32067500615)
A facile procedure was described for the hapten design of the N-methylcarbamate insecticide propoxur.Two new haptens of propoxur(hapten 1a and hapten 1b) were synthesized by introducing appropriate spacers in the pest...
关键词：HAPTEN design INSECTICIDE synthesis artificial antigen 
Characterization of Hapten-Protein Conjugates for Immunoassay of Polycyclic Aromatic Hydrocarbons(PAHs)被引量：3
《Chemical Research in Chinese Universities》2008年第6期697-700,共4页ZHANG Yan-feng GAO Zhi-xian SUN Hong-wen DAI Shu-gui 
Supported by National High-Tech Research and Development Program of China(No.2002AA649180);PhD Programs Foundation of Ministry of Education of China(No.20010055005)
Preparation and characterization of the hapten-protein conjugates are fundamental to developing environmental immunoassays. As a hapten, 1-pyrenebutyric acid（PBA） was conjugated to the carrier protein of bovine seru...
关键词：Polycyclic aromatic hydrocarbons HAPTEN Conjugate IMMUNOASSAY CHARACTERIZATION 
Application of Current Hapten in the Production of Broad Specificity Antibodies Against Organophosphorus Pesticides被引量：2
《Agricultural Sciences in China》2008年第11期1341-1347,共7页LIU Xian-jin YAN Chun-rong LIU Yuan YU Xiang-yang ZHANG Cun-zheng 
supported by the grants of National Natural Science Foundation of China (30471155);National 863 Program of China (2006AA06Z411)
Diethylphosphono acetic acid （DPA） was used as a current hapten to generate broad specificity polycolonal antibodies against a group of organophosphorus pesticides. Six New Zealand white rabbits were immunized with ...
关键词：organophosphorus pesticides broad specificity antibody enzyme-linked immunosorbent assay （ELISA） 
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