PRION

作品数：175被引量：154H指数：5
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Stable silver nanoparticles–aptamer bioconjugates for cellular prion protein imaging
《Chinese Science Bulletin》2014年第10期964-970,共7页Lei Zhan Li Peng Cheng-Zhi Huang 
supported by the National Basic Research Program of China(2011CB933600)
Combining the unique optical properties of metal nanoparticles and the specific recognition of aptamer,aptamer–nanoparticle conjugates have been extensively used in a wide range of applications,particularly multifunc...
关键词：nanoparticles APTAMER DITHIOCARBAMATE Cellular PRION protein 
Crystallization and preliminary X-ray crystallographic analysis of yeast prion protein Ure2p with shortened N-terminal被引量：1
《Chinese Science Bulletin》2001年第12期1012-1014,共3页WANG Liwei ZHU Li ZHOU Junmei RAO Zihe 
This work was supported by the National NaturalScience Foundation of China (Grant Nos. 39870174 and 39970155); the State "863" High-Tech Project (Grant No. 103130306); and "973" Project (Grant Nos. G1999075602, G1999011902 and 1998051105).
An orthorhombic crystal form of a recombi-nant yeast prion protein with shortened N-terminal, 90Ure2p, has been obtained. Crystals were grown by the vapordiffu-sion technique against a mother liquor containing imidazo...
关键词：YEAST PRION Ure2p crystallization. 
Evidence for oxidative damage to prion protein in prion diseases
《Chinese Science Bulletin》2000年第17期1546-1554,共9页YANG Chiming (Chi Ming Yang)Institute for Life Science and Health at UCSD, P. O. Box 12035, La Jolla, CA 92039, USA: College of Life Science & Biotechnology, Shanghai JiaoTong University. Shanghai 200030, China: College of Chemistry, Nankui University, Tianjin 300071, 
In prion diseases the irreversible protein structural transformation process is completed in the brains of mammals within a few months, the uniformly generated infectivity displays extraordinary resistance to inactiva...
关键词：PRION OXIDATIVE damage sequence-specific free RADICALS VARIANT of CREUTZFELDT-JAKOB disease (v CJD). 
Protein-only" or "virino" in prion diseases?被引量：2
《Chinese Science Bulletin》2000年第3期285-288,共4页YANG Chiming (Chi Ming Yang) & CHEN Yi1. Institute for Life Science and Health at UCSD, P.O.Box 12035, La Jolla, CA 92039, USA 2. Institute of Chemistry, Academy of Sciences, Beijing 100080, China Correspondence should be addressed to Yang Chiming 
60-year prion and scrapie research has led to a dilemma in understanding the unknown aetiology of the infectious neurodegenerative disorders with intriguing features. Current progress and dilemma in prion research are...
关键词：PRIONS MAD COW disease NEURODEGENERATIVE disorder subviral PATHOGEN PRION radical. 
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