NUCIFERINE

作品数：7被引量：45H指数：3
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相关领域：医药卫生更多>>
相关期刊：《Food Science and Human Wellness》《Chinese Journal of Natural Medicines》《Acta Pharmacologica Sinica》《China Medical Abstracts(Internal Medicine)》更多>>
相关基金：国家自然科学基金更多>>
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Nuciferine alleviates collagen-induced arthritic in rats by inhibiting the proliferation and invasion of human arthritis-derived fibroblast-like synoviocytes and rectifying Th17/Treg imbalance
《Chinese Journal of Natural Medicines》2024年第4期341-355,共15页WANG Hao GENG Xiaolong AI Fangbin YU Zhilun ZHANG Yan ZHANG Beibei LV Cheng GAO Ruiyang YUE Bei DOU Wei 
supported by the National Natural Science Foundation of China(No.82274329,82304991);the China Postdoctoral Science Foundation(No,2023M732336);Shanghai Science and Technology Committee Sailing Program Foundation(No.23YF1442500)。
Rheumatoid arthritis(RA)is a chronic autoimmune disorder marked by persistent synovial inflammation and joint degradation,posing challenges in the development of effective treatments.Nuciferine,an alkaloid found in lo...
关键词：Rheumatoid arthritis Collagen-induced arthritis Fibroblast-like synoviocyte Immune imbalance NUCIFERINE 
Nuciferine relieves type 2 diabetes mellitus via enhancing GLUT4 expression and translocation被引量：2
《Food Science and Human Wellness》2023年第6期2040-2051,共12页Tongxi Zhou Guanjun Song Di Tian Qinghua Liu Jinhua Shen Xinzhou Yang Ping Zhao 
financially supported by National Natural Science Foundation of China grants(81573561,81911540487,31070744);the Fundamental Research Funds for the Central Universities,South-Central University for Nationalities(CZR18003).
Nuciferine contained in lotus leaves have been confirmed to have the effect of ameliorating hyperlipemia and hyperglycemia.A laser scanning confocal microscope was used to track the translocation of glucose transporte...
关键词：NUCIFERINE Type 2 diabetes mellitus Glucose transporter 4(GLUT4) 
Nuciferine protects against high-fat diet-induced hepatic steatosis and insulin resistance via activating TFEB-mediated autophagy——lysosomal pathway被引量：10
《Acta Pharmaceutica Sinica B》2022年第6期2869-2886,共18页Xiliang Du Chiara Di Malta Zhiyuan Fang Taiyu Shen Xiaodi Niu Meng Chen Bo Jin Hao Yu Lin Lei Wenwen Gao Yuxiang Song Zhe Wang Chuang Xu Zhijun Cao Guowen Liu Xinwei Li 
supported by the National Natural Science Foundation of China (Beijing, China;grant Nos. U20A2062, 32022084, and 32002349);Jilin Province Science and Technology Development Project (Changchun, China;grant No. 20210508011RQ)
Nonalcoholic fatty liver disease(NAFLD) is characterized by hepatic steatosis and insulin resistance and there are currently no approved drugs for its treatment.Hyperactivation of mTOR complex1(mTORCl) and subsequent ...
关键词：AUTOPHAGY Fatty liver Lotus leaf LYSOSOME MiT/TFE mTORC1 Ragulator TFEB 
Effects of nuciferine on Nrf2/HO-1 signaling pathway in adipose tissue of obesity model rats
《Food Therapy and Health Care》2022年第1期1-5,共5页Zhi-Xia Yang Jia-Bao Liao 
This work was supported by the Science and Technology Project of Jiaxing.(No.2018AY3207)。
Objective:This study aimed to explore the therapeutic effect of nuciferine on high-fat diet-induced obesity in rats and the influence of nuciferine on nuclear factor erythroid 2-related factor 2(Nrf2)/heme oxygenase-1...
关键词：OBESITY NUCIFERINE ANTIOXIDANT Nrf2/HO-1 signaling pathway 
Nuciferine downregulates microRNA-33a-5p expression and upregulates ABCA1/G1 expressionin THP-1 derived macrophages
《China Medical Abstracts(Internal Medicine)》2017年第1期29-,共1页佟文娟 
Objective To explore the effects of nuciferine on the expression of microRNA-33a-5p(miR-33a-5p)and ATPbinding cassette transporter A1/G1(ABCA1/G1)in THP-1 derived macrophages.Methods Macrophages were derived from THP-...
关键词：THP MICRORNA 
Identification of the anti-tumor activity and mechanisms of nuciferine through a network pharmacology approach被引量：27
《Acta Pharmacologica Sinica》2016年第7期963-972,共10页Quan QI Rui LI Hui-ying LI Yu-bing CAO Ming BAI Xiao-jing FAN Shu-yan WANG Bo ZHANG Shao LI 
Aim： Nuciferine is an aporphine alkaloid extracted from lotus leaves, which is a raw material in Chinese medicinal herb for weight loss. In this study we used a network pharmacology approach to identify the anti-tumo...
关键词：NUCIFERINE TCM network pharmacology anti-tumor agent NEUROBLASTOMA colorectal cancer PI3K-AKT IL-1 drugClPHER 
Characterization of nuciferine metabolism by P450 enzymes and uridine diphosphate glucuronosyltransferases in liver microsomes from humans and animals被引量：7
《Acta Pharmacologica Sinica》2010年第12期1635-1642,共8页Yan-liu LU Yu-qi HE Miao WANG Li ZHANG Li YANG Zheng-tao WANG Guang JI 
Aim： To characterize the metabolism of nuciferine by P450 enzymes and uridine diphosphate glucuronosyltransferase （UGT） in liver microsomes from humans and several other animals including rats, mice, dogs, rabbits ...
关键词：NUCIFERINE METABOLISM cytochrome P450 UGT species differences rats mice RABBITS MONKEYS human 
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