CARDAMONIN

作品数:4被引量:30H指数:3
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相关领域:医药卫生更多>>
相关期刊:《Acta Pharmacologica Sinica》《Chemical Research in Chinese Universities》《Acta Pharmaceutica Sinica B》更多>>
相关基金:国家自然科学基金国家科技支撑计划更多>>
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Cardamonin protects against lipopolysaccharide-induced myocardial contractile dysfunction in mice through Nrf2-regulated mechanism被引量:4
《Acta Pharmacologica Sinica》2021年第3期404-413,共10页Ying Tan Hong-hong Wan Ming-ming Sun Wen-jing Zhang Maolong Dong Wei Ge Jun Ren Hu Peng 
supported in part by the National Natural Science Foundation of China(81671938,81571895).
In patients with sepsis,lipopolysaccharide(LPS)from the outer membrane of gram-negative bacteria triggers cardiac dysfunction and heart failure,but target therapy for septic cardiomyopathy remains unavailable.In this ...
关键词:CARDAMONIN LIPOPOLYSACCHARIDE cardiac dysfunction INFLAMMATION apoptosis oxidative stress 
Measurement of Free and Glucuronidated Cardamonin in Rat Plasma and Bile Using UPLC-MS/MS and Its Application to a Pharmacokinetic and Bile Excretion Study
《Chemical Research in Chinese Universities》2019年第6期962-966,共5页WU Yi JING Runan JIA Guihua WANG Yixiao YU Tianmiao ZHANG Weidong 
A rapid and accurate ultra-high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry(UPLC-MS/MS)method was established and validated for the measurement of two forms of cardamonin,i.e.,fr...
关键词:Glucuronidated CARDAMONIN Pharmacokinetics BILE EXCRETION Ultra-high-performance liquid cliromatography-electrospray ionization-tandem mass spectrometr\(UPLC-MS/MS) 
Cardamonin from a medicinal herb protects against LPS-induced septic shock by suppressing NLRP3 inflammasome被引量:24
《Acta Pharmaceutica Sinica B》2019年第4期734-744,共11页Zhilei Wang Guang Xu Yuan Gao Xiaoyan Zhan Nan Qin Shubin Fu Ruisheng Li Ming Niu Jiabo Wang Youping Liu Xiaohe Xiao Zhaofang Bai 
supported by the National Key Technology R&D Program(No.2017ZX09301022);the National Key Technology R&D Program(No.2015ZX09501-004-001-008);the BeijingNova program(No.Z181100006218001);the National Natural Science Foundation of China(No.81630100)
Aberrant activation of NLRP3 inflammasome has been implicated in the pathogenesis of diverse inflammation-related diseases, and pharmacological molecules targeting NLRP3 inflammasome are of considerable value to ident...
关键词:CARDAMONIN NLRP3 INFLAMMASOME IL-1β CASPASE-1 SEPTIC shock 
Characterization of cardamonin metabolism by P450 in different species via HPLC-ESI-ion trap and UPLC- ESI-quadrupole mass spectrometry被引量:3
《Acta Pharmacologica Sinica》2009年第10期1462-1470,共9页Yu-qi HE Li YANG Yong LIU Jiang-wei ZHANG Jun TANG Juan SU Yuan-yuan LI Yan-liu LU Chang-hong WANG Ling YANG Zheng-tao WANG 
Aim: To characterize the metabolism of cardamonin by the P450 enzymes in human and animal liver microsomes. Methods: Cardamonin was incubated with both human and animal liver microsomal incubation systems containing...
关键词:CARDAMONIN METABOLISM P450 human liver microsome species difference 
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