supported in part by the National Natural Science Foundation of China(81671938,81571895).
In patients with sepsis,lipopolysaccharide(LPS)from the outer membrane of gram-negative bacteria triggers cardiac dysfunction and heart failure,but target therapy for septic cardiomyopathy remains unavailable.In this ...
A rapid and accurate ultra-high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry(UPLC-MS/MS)method was established and validated for the measurement of two forms of cardamonin,i.e.,fr...
supported by the National Key Technology R&D Program(No.2017ZX09301022);the National Key Technology R&D Program(No.2015ZX09501-004-001-008);the BeijingNova program(No.Z181100006218001);the National Natural Science Foundation of China(No.81630100)
Aberrant activation of NLRP3 inflammasome has been implicated in the pathogenesis of diverse inflammation-related diseases, and pharmacological molecules targeting NLRP3 inflammasome are of considerable value to ident...
Aim: To characterize the metabolism of cardamonin by the P450 enzymes in human and animal liver microsomes. Methods: Cardamonin was incubated with both human and animal liver microsomal incubation systems containing...