SEPTIC

作品数：186被引量：494H指数：12
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相关领域：医药卫生更多>>
相关作者：黎介寿罗丹唐会杨建军纪木火更多>>
相关机构：南京军区南京总医院首都医科大学附属北京朝阳医院山东大学东南大学更多>>
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Nicotinamide mononucleotide protects septic hearts in mice via preventing cyclophilin F modification and lysosomal dysfunction
《Acta Pharmacologica Sinica》2025年第4期976-988,共13页Rui Ni Xiao-yun Ji Ting Cao Xiu-wen Liu Chao Wang Chao Lu Angel Peng Zhu-xu Zhang Guo-Chang Fan Jin Zhang Zhao-liang Su Tian-qing Peng 
supported by the Canadian Institute of Health Research(Grant No.PJT-180304 to TQP);Projects of International Cooperation from Jiangsu,China(Grant No.BZ2024031 to ZLS).
Myocardial dysfunction is a decisive factor of death in septic patients.Cyclophilin F(PPIF)is a major component of the mitochondrial permeability transition pore(mPTP)and acts as a critical mPTP sensitizer triggering ...
关键词：SEPSIS cyclophilin F LPS myocardial dysfunction nicotinamide mononucleotide Mito-TEMPO 
Current opinions on the use of prophylactic antibiotics in patients undergoing laparoscopic cholecystectomy
《World Journal of Gastrointestinal Surgery》2025年第3期427-430,共4页Efstathios T Pavlidis Ioannis N Galanis Theodoros E Pavlidis 
Inappropriate use of antibiotics leads to microbial resistance.Single-dose antibio-tic prophylaxis prior to laparoscopic cholecystectomy is well known for reducing the risk of postoperative infection in high-risk pati...
关键词：Prophylactic antibiotics Gallstone disease Laparoscopic cholecystectomy Acute cholecystitis Skin incision infection Septic complications 
Single-cell transcriptomics illustrates the immune inflammatory responses of septic mice spleen after capsaicin treatment
《Genes & Diseases》2025年第1期9-13,共5页Weijin Qiu Qian Zhang Jing Liu Xueling He Guangqing Cheng Jiayun Chen Yunmeng Bai Piao Luo Ping Gong Fei Shi Jigang Wang 
supported by the Establishment of Sino-Austria“Belt and Road”Joint Laboratory on Traditional Chinese Medicine for Severe Infectious Diseases and Joint Research(No.2020YFE0205100);the National Key Research and Development Program of China(No.2020YFA0908000);the Innovation Team and Talents Cultivation Program of the National Administration of Traditional Chinese Medicine(China)(No.ZYYCXTD-C-202002);the National Natural Science Foundation of China(No.82074098,81841001);the Fundamental ResearchFunds for the Central Public Welfare Research Institutes(China)(No.ZZ13-ZD-07,ZXKT18003,ZZ14-YQ-050,ZZ14-ND-010,ZZ15-ND-10,ZZ14-FL-002,ZZ14-YQ059,ZZ15-YQ-063);Shenzhen Science and Technology Innovation Commission(Guangdong,China)(No.JCYJ20210324115800001 and JCYJ20210324114014039);the National Key R&D Program of China Key projects for international cooperation on science,technology and innovation(No.2020YFE0205100);the Shenzhen Medical Research Fund of Shenzhen Medical Academy of Research and Translation(Guangdong,China)(No.B2302051);the Distinguished Expert Project of Sichuan Province Tianfu Scholar(China)(No.CW202002);China Academy of Chinese MedicalSciencess(CACMS)InnovationFund(No.CI2023E002);State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs.
Sepsis,a life-threatening condition triggered by a dysregulated host response to infection,remains a major challenge for therapeutic intervention.Despite the growing interest in immunomodulatory strategies for sepsis ...
关键词：inflammatory CAPSAICIN TREATMENT 
Nicotinamide adenine dinucleotide rejuvenates septic bone marrow mesenchymal stem cells
《World Journal of Stem Cells》2025年第2期53-67,共15页Xin Xia Kun Zhou Lin-Ying An Min Zhao Bin-Le Tian Jin-Yan Zhao Zhi-Gang Zhou Yin Tong 
Shanghai Natural Science Foundation,No.21ZR1452300;the Clinical Research Innovation Plan of Shanghai General Hospital,No.CCTR-2022B04.
BACKGROUND Sepsis is a severe illness characterized by systemic and multiorgan reactive responses and damage.However,the impact of sepsis on the bone marrow,particularly on bone marrow mesenchymal stem cells(BMSCs),is...
关键词：SEPSIS Bone mesenchymal stem cells Hematopoietic stem cells SENESCENCE Nicotinamide adenine dinucleotide 
Effectiveness and safety of Shenfu injection in septic patients with hypoperfusion:A multi-center,open-label,randomized,controlled trial
《Journal of Intensive Medicine》2024年第4期484-490,共7页Di Liu Tingting Pan Xiang Li Duming Zhu Yingchuan Li Hongyu He Fang Wu Lijing Jiang Yang Chen Xiaoli Wang Jialin Liu Ruoming Tan Hongping Qu 
supported by the Shanghai Municipal Health and Family Planning Commission General Hospital Chinese and Western Medicine Clinical Cooperation Pilot Construction Project,grant number:ZY(2018-2020)-FWTX-1108.
Background:To evaluate the effectiveness and safety of the Shenfu injection(SFI)combined with standard bundle treatment in septic patients with hypoperfusion.Method:This study was a multi-center,randomized,open-label,...
关键词：SEPSIS Shenfu injection Traditional Chinese medicine Prognosis 
Radix Sanguisorbae Improves Intestinal Barrier in Septic Rats via HIF-1α/HO-1/Fe^(2+)Axis
《Chinese Journal of Integrative Medicine》2024年第12期1101-1112,共12页LIU Yi-yan BAO Dai-qin ZHANG Zi-sen ZHU Yu LIU Liang-ming LI Tao 
Objective:To investigate whether Radix Sanguisorbae(RS,Diyu)could restore intestinal barrier function following sepsis using a cecal ligation and puncture(CLP)-induced septic rat model and lipopolysaccharide(LPS)-chal...
关键词：Radix Sanguisorbae SEPSIS ferroptosis intestinal barrier function network pharmacology Chinesemedicine 
Advancing cell-based therapy in sepsis:An anesthesia outlook
《Chinese Medical Journal》2024年第13期1522-1534,共13页Hui Ye Xiaoyu Zou Xiangming Fang 
National Natural Science Foundation of China(No.82230074)
Sepsis poses a health challenge globally owing to markedly high rates of morbidity and mortality.Despite employing bundle therapy over two decades,approaches including transient organ supportive therapy and clinical t...
关键词：SEPSIS PERIOPERATIVE Receptors chimeric antigen Immunotherapy adoptive Perfusion Tissue repair Multiple organ failure Shock septic 
Exploring the effects of coronary artery disease as a preexisting comorbidity on mortality in hospitalized septic patients:a retrospective observation study
《Emergency and Critical Care Medicine》2024年第2期47-51,共5页Anmol Multani Greg Stahl Kerry Johnson Scott Goade Robert D.Arnce 
The study followed the principles of the Declaration of Helsinki as revised in 2013.Institutional Review Board Steering Committee of FHS in Joplin,MO,issued approval to the study(approval no.2021002)on August 24,2020.Written informed consent was waived by the IRB of FHS owing to the retrospective observational study design and the anonymized data retrieved from the hospital database.
Background:Sepsis has high prevalence and mortality rate,and it is imperative to identify populations at risk of poor sepsis outcomes.Septic patients with preexisting chronic comorbidities are shown to have worse seps...
关键词：COMORBIDITY Coronary artery disease Inflammation Mortality rate in sepsis prognosis SEPSIS 
Xuebijing improves intestinal microcirculation dysfunction in septic rats by regulating the VEGF-A/PI3K/Akt signaling pathway
《World Journal of Emergency Medicine》2024年第3期206-213,共8页A-ling Tang Yan Li Li-chao Sun Xiao-yu Liu Nan Gao Sheng-tao Yan Guo-qiang Zhang 
supported by a grant from National Natural Science Foundation of China (82272196)。
BACKGROUND:This study aims to explore whether Xuebijing(XBJ) can improve intestinal microcirculation dysfunction in sepsis and its mechanism.METHODS:A rat model of sepsis was established by cecal ligation and puncture...
关键词：SEPSIS XUEBIJING Vascular endothelial growth factor A MICROCIRCULATION Rat Phosphoinositide 3-kinase Protein kinase B 
Is there sufficient evidence to support the use of antibiotic holiday just before the second stage of an infected total hip or knee arthroplasty revision surgery?
《World Journal of Orthopedics》2024年第5期483-485,共3页Konstantinos Tsikopoulos Konstantinos Sidiropoulos 
The practice of implementing an antibiotic holiday before the second stage of hip or knee arthroplasty is currently controversial due to limited evidence for this approach,as per the International Consensus Meeting 20...
关键词：Septic knee prosthesis revision Two stages Antibiotic holiday 
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