云南高校图书馆联盟文献共享服务平台- CALPASTATIN

CALPASTATIN: 作品数：22被引量：84H指数：5; 导出分析报告; 相关领域：医药卫生农业科学更多>>; 相关作者：唐仁勇余冰陈代文郑光华李志刚更多>>; 相关机构：四川农业大学中国医科大学沈阳农业大学北京中医药大学更多>>; 相关期刊：《International Journal of Ophthalmology(English edition)》《中国运动医学杂志》《广州中医药大学学报》《畜牧兽医学报》更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家体育总局应用基础研究项目泰国研究基金更多>>

Calpain/Calpastatin 在离体心脏中的表达分析: 《中文科技期刊数据库（全文版）医药卫生》2023年第10期9-11,共3页宋俊杰滕小梅叶文学; 研究 Calpain/Calpastatin系统在离体心脏中表达变化规律并探索 Calpastatin 过表达的方法,为离体心脏保护机制研究提供方法。方法 (1)获取小鼠心脏后用微量灌注泵灌注HTK液2 h,置于4 ℃ HTK心脏保存液中,模拟离体心脏冷缺血2 h、3 h、...; 关键词：离体心脏 CALPAIN CALPASTATIN SPECTRIN 腺病毒

Role of CAST-Drp1 Pathway in Retinal Neuron-Regulated Necrosis in Experimental Glaucoma被引量：1: 《Current Medical Science》2023年第1期166-172,共7页Su-mei LIU Lv-shuang LIAO Ju-fang HUANG Shu-chao WANG; supported by the National Natural Science Foundation of China(No.82101126);the Natural Science Foundation of Hunan Province(No.2021JJ40873).; Objective Numerous studies have indicated that excitatory amino acid toxicity,such as glutamate toxicity,is involved in glaucoma.In addition,excessive glutamate can lead to an intracellular calcium overload,resulting ...; 关键词：retinal ganglion cells GLAUCOMA CALPASTATIN dynamin-related protein l central nervous system regulated necrosis GLUTAMATE

Targeted inhibition of calpain in mitochondria alleviates oxidative stress-induced myocardial injury被引量：4: 《Acta Pharmacologica Sinica》2021年第6期909-920,共12页Dong Zheng Ting Cao Lu-lu Zhang Guo-chang Fan Jun Qiu Tian-qing Peng; the Natural Science Foundation of Jiangsu Province(BK20171216)。; The protein levels and activities of calpain-1 and calpain-2 are increased in cardiac mitochondria under pathological conditions including ischemia,diabetes,and sepsis,and transgenic overexpression of mitochondrial-ta...; 关键词：CALPAIN CALPASTATIN heart myocardial injury MITOCHONDRIA oxidative stress ATP synthase HYPERGLYCEMIA global ischemia-reperfusion

Targeting molecular pathways for the treatment of inherited retinal degeneration被引量：2: 《Neural Regeneration Research》2020年第10期1784-1791,共8页Meltem Kutluer Li Huang Valeria Marigo; supported by grants from the Telethon Foundation(GGP14180,GGP19113);the European Union(LSHGCT-2005-512036 and transMed,MSCA-ITN-2017-765441)(all to VM); Inherited retinal degeneration is a major cause of incurable blindness characterized by loss of retinal photoreceptor cells.Inherited retinal degeneration is characterized by high genetic and phenotypic heterogeneity ...; 关键词：ACHROMATOPSIA calcium CALPAINS CALPASTATIN congenital stationary night blindness Leber’s congenital amaurosis retinitis pigmentosa stargardt disease

Calpastatin participates in the regulation of cell migration in BAP1-deficient uveal melanoma cells: 《International Journal of Ophthalmology(English edition)》2019年第11期1680-1687,共8页Han Yue Feng-Xi Meng Jiang Qian Bin-Bin Xu Gang Li Ji-Hong Wu; Supported by the Science and Technology Commission of Shanghai (No.14411961800); AIM: To detect how BRCA-associated protein 1(BAP1) regulates cell migration in uveal melanoma(UM) cells. METHODS: Wound healing and transwell assays were performed to detect UM cell migration abilities. Protein chip, ...; 关键词：UVEAL MELANOMA BRCA-associated protein 1 CALPASTATIN cell migration

Calpastatin减轻病毒性心肌炎心脏炎症损伤的作用被引量：3: 《中国分子心脏病学杂志》2019年第2期2848-2852,共5页虞莹石卉虞勇陈瑞珍; 国家自然科学基金青年项目(81600294)国家自然科学基金面上项目(31570904); 目的探讨钙蛋白酶抑制蛋白(calpastatin)对柯萨奇B组病毒3型(coxsackievirus B3, CVB3)诱导的病毒性心肌炎小鼠心脏炎症损伤的作用。方法取全身过表达calpastatin的转基因小鼠(Tg-CAST)及野生型小鼠(WT)腹腔注射CVB3,感染病毒7d后建立...; 关键词：钙蛋白酶抑制蛋白炎症核因子κβ

Regulatory role of calpain in neuronal death被引量：6: 《Neural Regeneration Research》2018年第3期556-562,共7页Si-ying Cheng Shu-chao Wang Ming Lei Zhen Wang Kun Xiong; supported by the National Natural Science Foundation of China,No.81571939&81772134;the Wu Jie-Ping Medical Foundation of the Minister of Health of China,No.320.6750.14118;the Natural Science Foundation of Hunan Province of China,No.2015JJ2187;the Teacher Research Foundation of Central South University of China,No.2014JSJJ026; Calpains are a group of calcium-dependent proteases that are over activated by increased intracellular calcium levels under pathological conditions. A wide range of substrates that regulate necrotic, apoptotic and aut...; 关键词：nerve regeneration CALPAIN CALPASTATIN central nervous system APOPTOSIS AUTOPHAGY B-cell lymphoma cyclin-dependent kinases mitochondrial permeability transition neural regeneration

钙激活蛋白酶系统对细胞凋亡过程的影响概述: 《牡丹江医学院学报》2017年第4期95-98,共4页高士友潘大彬; 钙激活蛋白酶(Calpains)属于一类Ca2+依赖半胱氨酸蛋白水解酶超家族成员,Calpains系统与细胞凋亡关系密切,在细胞凋亡中发挥重要作用。目前研究表明Calpains系统通过调节凋亡信号传导途径参与细胞凋亡,在蛋白、分子、基因水平上调控细...; 关键词：钙激活蛋白酶钙激活蛋白酶抑制蛋白 CALPAINS CALPASTATIN 细胞凋亡

Neuroprotective effect of Spilanthes acmella Murr. on pesticide-induced neuronal cells death被引量：1: 《Asian Pacific Journal of Tropical Medicine》2017年第1期35-41,共7页Wilasinee Suwanjang Bongkot Khongniam Sujittra Srisung Supaluk Prachayasittikul Virapong Prachayasittikul; supported by Mahidol University and the Thailand Research Fund(TRF)under a research grant for new scholar(MRG5980032)to WS;by the office of the Higher Education Commission,Mahidol University,under the National Research Universities Initiative; Objective: To investigate protective effects of Spilanthes acmella(S,acmella) Murr,extracts against pesticide-induced neuronal cells death and to elucidate the underlying molecular mechanism in dopaminergic(SH-SY5Y) c...; 关键词：Spilanthes acmella Murr. PIRIMICARB PESTICIDE Neuronal cell CALPAIN CALPASTATIN

Calpain2及其抑制剂在肝纤维化细胞凋亡中的机制被引量：1: 《重庆医科大学学报》2014年第7期960-963,共4页谢汝佳韩冰杨婷邹河杨勤; 贵州省科技厅国际科技合作资助项目(编号:黔科合外G字【2010】7016号); 目的:探讨钙中性蛋白酶2(calpain2)及其抑制剂calpastatin在肝纤维化过程中的表达变化及他们在肝细胞凋亡中的作用。方法:雄性Wistar大鼠40只,随机分为正常组4、8周组和肝纤维化4、8周组,每组各10只。肝纤维化组按0.3 ml/100 g体质量皮...; 关键词：肝纤维化钙中性蛋白酶2 CALPASTATIN

CALPASTATIN