KNOCKDOWN

作品数：194被引量：560H指数：11
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相关领域：医药卫生生物学更多>>
相关作者：孙琳琳钟殿胜吴松陈哲余林中更多>>
相关机构：中国科学院大学温州医科大学南京医科大学华中农业大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划广东省自然科学基金国家高技术研究发展计划更多>>
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Knockdown of SlEMS1 causes male sterility in tomato
《Horticultural Plant Journal》2025年第2期939-942,共4页Yu He Juan Wang Jingang Hu Jinhui Zheng Ziyi Guo Qinghui Yu Qinghua Shi Yan Zhang 
supported by the National Natural Science Foundation of China(Grant No.32372723,U1906205);Key Research and Development Program of Shandong Province(Grant No.2023CXPT018,2022TZXD0025);Natural Science Foundation of Shandong Province(Grant No.ZR2023MC206);Key Research and Development Task Special Project of Xinjiang(Grant No.2022B02002)。
Tomato(Solanum lycopersicum)is one of the most consumed vegetable crops around the world,and its breeding is performed by exploiting heterosis in F1hybrid crosses.Male sterility is one of the most desirable agronomic ...
关键词：BREEDING CROPS COMPREHENSIVE 
Knockdown of vitellogenin receptor based on minute insect RNA interference methods affects the initial mature egg load in the pest natural enemy Trichogramma dendrolimi
《Insect Science》2025年第2期487-500,共14页Cheng-Xing Wang Hui-Qiao Bao Zhi-Chao Yan Jie Wang Su Wang Yuan-Xi Li 
supported by the National Natu-ral Science Foundation of China(32172483);Jiangsu Agriculture Science and Technology Innovation Fund(CX(22)3012);National Key R&D Plan of China(2023YFD1400605).
Vitellogenin receptor(VgR)plays a crucial role in oogenesis by mediating en-docytosis of vitellogenin and a portion of the yolk proteins in many insect species.How-ever,the function of VgR in minute parasitoid wasps i...
关键词：initial mature egg load ovarian dysplasia parasitic capacity RNA interference vitellogenin receptor 
Centromere protein A knockdown inhibits rectal cancer through O6- methylguanine DNA methyltransferase/protein tyrosine phosphatase nonreceptor type 4 axis
《World Journal of Gastrointestinal Oncology》2025年第4期347-364,共18页Ming-Jie Xin Yong Yuan 
This study was reviewed and approved by the Ethic Committee of Medical College of Henan Vocational University of Science and Technology(Approval No.HVUYL414101416920231017001);all participants signed a written informed consent.
BACKGROUND Centromere protein A(CENPA)exhibits an increased expression level in primary human rectal cancer tissues,but its role has not been investigated.AIM To clarify the specific role and mechanism of CENPA in rec...
关键词：Rectal cancer Centromere protein A O6-methylguanine DNA methyltransferase Protein tyrosine phosphatase nonreceptor type 4 PROLIFERATION INVASION 
Establishing Programmable CRISPR/Cas13b-Mediated Knockdown System in Rice
《Rice science》2025年第2期217-227,I0043-I0046,共15页WANG Shuman ZHANG Linqi GAO Ruiren WEI Guangbo DONG Weiguo XU Jiming WANG Zhiye 
supported by the Natural Science Foundation of Zhejiang Province,China(Grant Nos.LZ22C150002 and LR24C150001);the National Key Research and Development Program of China(Grant Nos.2021YFF1000402 and 2022YFD1401600);the National Natural Science Foundation of China(Grant No.32170262);the Fundamental Research Funds for the Central Universities,China(Grant No.K20240124).
CRISPR-Cas endonucleases mediate prokaryotic adaptive immunity by targeting foreign nucleic acids.CRISPR/Cas13b is a class 2 type VI-B ribonuclease that targets and cleaves single-stranded RNA.It exhibits higher RNA i...
关键词：CRISPR/Cas13b RNA knockdown system RICE collateral effect inorganic phosphate starvation 
Mettl1 knockdown alleviates cardiac I/R injury in mice by inactivating the Mettl1-CYLD-P53 positive feedback loop
《Acta Pharmacologica Sinica》2025年第3期592-605,共14页Shu-ting Yu Zhi-yong Sun Na Li Zhe-zhe Qu Chang-hao Wang Tian-tian Ju Ying-qi Liu Zhong-ting Mei Kui-wu Liu Mei-xi Lu Min Huang Ying Li Shun-kang Dou Jian-hao Jiang Yao-zhi Zhang Chuan-hao Huang Xiao-chen Pang Ying-qiong Jia Xian-hui Dong Fan Wu Yi Zhang Wan-hong Li Bao-feng Yang Wei-jie Du 
supported by grants from the National Natural Science Foundation of China(82273928,82473919,82330011,U21A20339);Natural Science Foundation for Distinguished Young Scholars of Heilongjiang Province(2024JQ0107);Youth Project of Scientific Research Institution of Heilongjiang Province(CZKYF2023-1-C047);CAMS Innovation Fund for Medical Sciences(CIFMS,2020-I2M-5-003).
The N7-methylguanosine(m7G)methyltransferase Mettl1 has been recently implicated in cardiac repair and fibrosis.In this study we investigated the role of Mettl1 in mouse cardiomyocytes injury and the underlying mechan...
关键词：cardiac ischemia/reperfusion injury Mettl1 m7G CYLD P53 UBIQUITINATION 
HMGB2 knockdown ameliorates retinal ganglion cell injury by inhibiting NLRP3 inflammasome activation after retinal ischemia
《International Journal of Ophthalmology(English edition)》2025年第1期39-50,共12页Lin-Ping Xue Hai-Song Feng 
Supported by Science and Technology Research Project of Hubei Provincial Department of Education(No.B2021108).
AIM:To explore the neuroprotective effects of high mobility group box 2(HMGB2)knockdown on retinal ganglion cells(RGCs)in the retinal ischemia-reperfusion injury(RIRI).METHODS:Oxygen-glucose deprivation(OGD)-injured R...
关键词：HMGB2 retinal ischemia-reperfusion injury retinal ganglion cell apoptosis PYROPTOSIS NLRP3 mice 
A CRISPR/RfxCas13d-mediated strategy for efficient RNA knockdown in mouse embryonic development
《Science China(Life Sciences)》2024年第11期2297-2306,共10页Lin Zhang Shi-Meng Cao Hao Wu Meng Yan Jinsong Li Ling-Ling Chen 
supported by the Strategic Priority Research Program of the Chinese Academy of Science(XDB0570000);the CAS Project for Young Scientists in Basic Research(YSBR-009);the National Key Research and Development Program of China(2021YFA1100203,2020YFA0509000);the National Natural Science Foundation of China(31821004,32030029,32293230);Shanghai Municipal Science and Technology Major Project(23HC1401000,22YS1400900);support from the Xplorer Prize and New Cornerstone Science Foundation(NCI202232).
The growing variety of RNA classes,such as mRNAs,lncRNAs,and circRNAs,plays pivotal roles in both developmental processes and various pathophysiological conditions.Nonetheless,our comprehension of RNA functions in liv...
关键词：sperm-like stem cell semi-cloned technology CRISPR-RfxCas13d RNA knockdown embryonic development 
UHRF1 knockdown induces cell cycle arrest and apoptosis in breast cancer cells through the ZBTB16/ANXA7/Cyclin B1 axis
《Acta Biochimica et Biophysica Sinica》2024年第11期1633-1643,共11页Di Liu Qin Du Yuxuan Zhu Yize Guo Ya Guo 
This work was supported by the grants from the Science and Technology Project of Shaanxi Province(No.2022SF-496);the Key Research and Development Program of Shaanxi Province(No.2022SF-213);the Funds of the Second Affiliated Hospital of Xi’an Jiaotong University for Scientists(No.RC(GG201807));the Funds of the Second Affiliated Hospital of Xi’an Jiaotong University(Nos.YJ(ZYTS)2019012 and 2020YJ(ZYTS)226);the Xinrui Cancer Research Support Program(No.cphcf-2022-231);The Medical Research Developing Funds(No.KM228009).
Ubiquitin-like containing PHD and RING finger domains 1(UHRF1)is involved in tumorigenicity through DNA methylation in various cancers,including breast cancer.This study aims to investigate the regulatory mechanisms o...
关键词：breast cancer cell cycle UHRF1 DNA methylation the ZBTB16/ANXA7/Cyclin B1 axis 
Knockdown of the atypical protein kinase genes GhABC1K2-A05 and GhABC1K12-A07 make cotton more sensitive to salt and PEG stress被引量：1
《Journal of Integrative Agriculture》2024年第10期3370-3386,共17页Caixiang Wang Meili Li Dingguo Zhang Xueli Zhang Juanjuan Liu Junji Su 
supported by the State Key Laboratory of Aridland Crop Science,Gansu Agricultural University,China(GSCS-2019-10);the National Natural Science Foundation of China(31801414 and 32260478);the Gansu Province Science and Technology Program,China(20JR10RA531);the Natural Science Foundation of Xinjiang Uygur Autonomous Region,China(2022D01E103);the Education Technology Innovation Project of Gansu Province,China(2022QB-076)。
Activity of bc1 complex kinase(ABC1K)is an atypical protein kinase(aPK)that plays a crucial role in plant mitochondrial and plastid stress responses,but little is known about the responses of ABC1Ks to stress in cotto...
关键词：COTTON ABC1K abiotic stress responses expression patterns virus-induced gene silencing(VIGS) 
In situ direct reprogramming of astrocytes to neurons via polypyrimidine tract-binding protein 1 knockdown in a mouse model of ischemic stroke被引量：1
《Neural Regeneration Research》2024年第10期2240-2248,共9页Meng Yuan Yao Tang Tianwen Huang Lining Ke En Huang 
supported by the National Natural Science Foundation of China,No.82071418;the Natural Science Foundation of Fujian Province,No.2020J01612 (both to EH)。
In situ direct reprogramming technology can directly convert endogenous glial cells into functional neurons in vivo for central nervous system repair. Polypyrimidine tract-binding protein 1(PTB) knockdown has been sho...
关键词：astrocyte in situ direct reprogramming ischemic stroke miR-30 based shRNA neuron polypyrimidine tract-binding protein 1 TRANSDIFFERENTIATION 
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