Beijing Natural Science Foundation,No.7202216;National Natural Science Foundation of China,No.81970698 and No.81970708.
BACKGROUND Chiglitazar is an emerging pan-agonist of all peroxisome proliferator activated receptors(PPAR)-α,δandγ,and has therapeutic potential for type 2 diabetes(T2D).However,to date,no clinical studies or meta-...
The peroxisome proliferator activator receptor-γ (PPAR-γ) remained the most effective target for management of diabetes mellitus. The present work endeavors rational designing new PPAR-γ ...
Exercise therapy is essential for the management of type 2 diabetes(T2 D). However, patients with T2 D show lower physical activity and reduced cardiorespiratory fitness than healthy individuals. It would be ideal for...
supported by National Institute of Food and Agriculture (Grant: ILLU-538-914)
Background: The objective of the study was to evaluate the effect of overfeeding a moderate energy diet and a2,4-thiazolidinedione(TZD) injection on blood and hepatic tissue biomarkers of lipid metabolism, oxidativ...
Nonalcoholic fatty liver disease(NAFLD)is quickly becoming one of the most prominent causes of liver disease worldwide.The increasing incidence of NAFLD is tied to the obesity epidemic and the subsequent metabolic der...
A facile preparation of ZnO nanobelts by chemical precipitation technique and its utility as catalyst in Knoevenagel condensation of 2,4-thiazolidinedione/rhodanine has been described. X-ray diffraction and transmissi...
Project supported by the National Natural Science Foundation of China (No. 20972132).
The polysubstituted thiophene derivatives were conveniently prepared by the four-component reactions of 1,3-thiazolidinedione, aromatic aldehydes, cyanoacetamide and cyclic secondary amines such as pyrrolidine, mor- p...
An efficient synthesis of 5-arylidine-2,4-thiazolidinediones has been developed using dicationic ionic liquid as green medium and catalyst. This method performed well for the condensation of both aryl as well as heter...
supported by NIH Grant DK068036 and DK085495 to J Ye.
Thiazolidinedione(TZD)is a powerful insulin sensitizer in the treatment of type 2 diabetes.It acts as a ligand to the nuclear receptor PPARγ(peroxisome proliferator-activated receptor-gamma)and induces transcription ...