THIAZOLIDINEDIONE

作品数:17被引量:76H指数:5
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相关领域:医药卫生更多>>
相关作者:杨欣田之悦薛英池芝盛何芬更多>>
相关机构:台湾大学西南大学四川大学北京协和医院更多>>
相关期刊:《World Journal of Diabetes》《中国糖尿病杂志》《Open Journal of Medicinal Chemistry》《Journal of Animal Science and Biotechnology》更多>>
相关基金:国家自然科学基金更多>>
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Indirect comparison of efficacy and safety of chiglitazar and thiazolidinedione in patients with type 2 diabetes:A meta-analysis被引量:1
《World Journal of Diabetes》2023年第10期1573-1584,共12页Chu Lin Zong-Lin Li Xiao-Ling Cai Sui-Yuan Hu Fang Lv Wen-Jia Yang Li-Nong Ji 
Beijing Natural Science Foundation,No.7202216;National Natural Science Foundation of China,No.81970698 and No.81970708.
BACKGROUND Chiglitazar is an emerging pan-agonist of all peroxisome proliferator activated receptors(PPAR)-α,δandγ,and has therapeutic potential for type 2 diabetes(T2D).However,to date,no clinical studies or meta-...
关键词:Chiglitazar THIAZOLIDINEDIONE Glycemic control β-cell function Drug safety 
Targeting PPAR<i>γ</i>Receptor Using New Phosphazene Derivative Containing Thiazolidinedione: Design, Synthesis, and Glucose Uptake
《Open Journal of Medicinal Chemistry》2020年第2期35-45,共11页Shaikha S. Al Neyadi Abdu Adem Naheed Amir Ibrahim M. Abdou 
The peroxisome proliferator activator receptor-γ (PPAR-γ) remained the most effective target for management of diabetes mellitus. The present work endeavors rational designing new PPAR-γ ...
关键词:Type 2 Diabetes PPARS TZD Compound CYCLOTRIPHOSPHAZENE 
Effects of glucose-lowering agents on cardiorespiratory fitness
《World Journal of Diabetes》2018年第12期230-238,共9页Hidetaka Hamasaki 
Exercise therapy is essential for the management of type 2 diabetes(T2 D). However, patients with T2 D show lower physical activity and reduced cardiorespiratory fitness than healthy individuals. It would be ideal for...
关键词:Type 2 diabetes Glucagon-like peptide l receptor AGONIST CARDIORESPIRATORY fitness Exercise capacity METFORMIN THIAZOLIDINEDIONE Sodium-glucose COTRANSPORTER 2 inhibitors 
Level of dietary energy and 2,4-thiazolidinedione alter molecular and systemic biomarkers of inflammation and liver function in Holstein cows
《Journal of Animal Science and Biotechnology》2018年第1期145-155,共11页Afshin Hosseini Mustafa Salman Zheng Zhou James K.Drackley Erminio Trevisi Juan J.Loor 
supported by National Institute of Food and Agriculture (Grant: ILLU-538-914)
Background: The objective of the study was to evaluate the effect of overfeeding a moderate energy diet and a2,4-thiazolidinedione(TZD) injection on blood and hepatic tissue biomarkers of lipid metabolism, oxidativ...
关键词:INFLAMMATION Insulin sensitivity Nutrition PPAR 
Nonalcoholic fatty liver disease:A comprehensive review of a growing epidemic被引量:38
《World Journal of Gastroenterology》2014年第34期12082-12101,共20页Kareem Hassan Varun Bhalla Mohammed Ezz El Regal H Hesham A-Kader 
Nonalcoholic fatty liver disease(NAFLD)is quickly becoming one of the most prominent causes of liver disease worldwide.The increasing incidence of NAFLD is tied to the obesity epidemic and the subsequent metabolic der...
关键词:Nonalcoholic fatty liver disease STEATOHEPATITIS Nonalcoholic steatohepatitis PATHOGENESIS TREATMENTS Diagnosis Management METFORMIN Vitamin E THIAZOLIDINEDIONE Imaging Prevalence 
ZnO Nanobelts: An Efficient Catalyst for Synthesis of 5-Arylidine-2,4-Thiazolidinediones and 5-Arylidine-Rhodanines
《International Journal of Organic Chemistry》2012年第3期305-310,共6页Suresh   Jagir S. Sandhu 
A facile preparation of ZnO nanobelts by chemical precipitation technique and its utility as catalyst in Knoevenagel condensation of 2,4-thiazolidinedione/rhodanine has been described. X-ray diffraction and transmissi...
关键词:ZnO NANOBELTS KNOEVENAGEL Condensation 2 4-Thiazolidinedione RHODANINE Solvent-Free 
Synthesis of Functionalized Thiophenes by Four-component Reactions of 1,3-Thiazolidinedione, Aromatic Aldehydes, Cyanoacetamide and Cyclic Secondary Amines
《Chinese Journal of Chemistry》2011年第11期2461-2464,共4页姚荣 夏二艳 孙晶 颜朝国 
Project supported by the National Natural Science Foundation of China (No. 20972132).
The polysubstituted thiophene derivatives were conveniently prepared by the four-component reactions of 1,3-thiazolidinedione, aromatic aldehydes, cyanoacetamide and cyclic secondary amines such as pyrrolidine, mor- p...
关键词:multicomponent reaction domino reaction THIOPHENE CYANOACETAMIDE 1 3-thiazolidinedione 
噻唑烷二酮(Thiazolidinedione)类药物与女性骨折风险增加有关
《基础医学与临床》2011年第8期852-852,共1页
据美国WedMD大众医疗新闻网(2010-02-24)报道,一项发表于2月《临床内分泌与代谢》期刊的回溯性研究指出,使用噻唑烷二酮类药物与女性骨折风险增加有关,特别是年龄大于65岁的女性。
关键词:噻唑烷二酮类药物 骨折风险 女性 内分泌 
Dicationic Ionic Liquid Mediated Synthesis of 5-Arylidine-2,4-thiazolidinediones被引量:2
《Chinese Journal of Chemistry》2011年第5期942-946,共5页Jawale Dhanaji V. Pratap Umesh R. Lingampalle Dinesh L. Mane Ramrao A. 
An efficient synthesis of 5-arylidine-2,4-thiazolidinediones has been developed using dicationic ionic liquid as green medium and catalyst. This method performed well for the condensation of both aryl as well as heter...
关键词:2 4-thiazolidinedione dicationic ionic liquid type 2 diabetes mellitus Knoevenagel condensation sul- fur heterocycles aldehydes 
Challenges in drug discovery for thiazolidinedione substitute被引量:6
《Acta Pharmaceutica Sinica B》2011年第3期137-142,共6页Jian-ping Ye 
supported by NIH Grant DK068036 and DK085495 to J Ye.
Thiazolidinedione(TZD)is a powerful insulin sensitizer in the treatment of type 2 diabetes.It acts as a ligand to the nuclear receptor PPARγ(peroxisome proliferator-activated receptor-gamma)and induces transcription ...
关键词:PPARγligands THIAZOLIDINEDIONE Type 2 diabetes Insulin sensitizer Side effect Histone deacetylase inhibitor 
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