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作品数：41被引量：44H指数：4
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相关领域：医药卫生生物学更多>>
相关作者：冯献礼王乙博孙铁东于辉黄旭日更多>>
相关机构：吉林大学德州学院北京大学重庆医科大学附属第二医院更多>>
相关期刊：《World Journal of Clinical Cases》《World Journal of Clinical Oncology》《Chinese Journal of Cancer Research》《Progress in Natural Science:Materials International》更多>>
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Bibliometric analysis of olaparib and pancreatic cancer from 2009 to 2022:A global perspective
《World Journal of Gastrointestinal Oncology》2024年第11期4489-4505,共17页Xu Feng Yi-Han Chai Ke-Xin Jiang Wen-Bin Jiang Wen-Chao Chen Yu Pan 
the Zhejiang Provincial Medical and Health Science and Technology Program,No.2024KY1109.
BACKGROUND Genetic screening for breast cancer gene 1(BRCA)1/2 mutations can inform breast/ovarian/pancreatic cancer patients of suitable therapeutic interventions.Four to seven percent of pancreatic cancer patients h...
关键词：OLAPARIB Pancreatic cancer Bibliometric analysis Breast cancer susceptibility gene Poly(adenosine diphosphate-ribose)polymerase 
Dietary ribose supplementation improves flesh quality through purine metabolism in gibel carp(Carassius auratus gibelio)
《Animal Nutrition》2023年第2期50-63,共14页Wanjie Cai Lele Fu Cui Liu Linyue He Haokun Liu Dong Han Xiaoming Zhu Yunxia Yang Junyan Jin Shouqi Xie 
supported by the National Key R&D Program of China(2018YFD0900400);the earmarked fund for CARS(CARS-45);China and National Natural Science Foundation of China(U21A20266)。
Since the aquaculture industry is currently observing a deterioration in the flesh quality of farmed fish,the use of nutrients as additives to improve the flesh quality of farmed fish species is a viable strategy.The ...
关键词：D-RIBOSE FLAVOUR Flesh quality Inosine monophosphate METABOLOMIC Purine metabolism 
Protective effect of liraglutide on the myocardium of type 2 diabetic rats by inhibiting polyadenosine diphosphate-ribose polymerase-1被引量：2
《World Journal of Diabetes》2023年第2期110-119,共10页Dong-Dong Xue Xiang Zhang De-Wei Li Yan-Lan Yang Jing-Jin Liu 
Supported by Shanxi Provincial Natural Science Foundation,No.201701D121159;Shanxi Provincial Health and Family Planning Commission,No.2014016;Health Commission of Shanxi Province,No.2019020.
BACKGROUND In recent years,studies have found that the occurrence and development of diabetic cardiomyopathy(DCM)is closely related to an increase in polyadenosine diphosphate-ribose polymerase-1(PARP-1)activity.PARP-...
关键词：LIRAGLUTIDE animal models Type 2 diabetic rats Polyadenosine diphosphate-ribose polymerase-1 Haematoxylin and eosin staining Immunohistochemistry 
Germline BRCA2 variants in advanced pancreatic acinar cell carcinoma:A case report and review of literature被引量：1
《World Journal of Gastroenterology》2022年第45期6421-6432,共12页Cha Len Lee Spring Holter Ayelet Borgida Anna Dodd Stephanie Ramotar Robert Grant Kristy Wasson Elena Elimova Raymond W Jang Malcolm Moore Tae Kyoung Kim Korosh Khalili Carol-Anne Moulton Steven Gallinger Grainne M O’Kane Jennifer J Knox 
BACKGROUND Pancreatic acinar cell carcinoma(PACC)is a rare tumor.Up to 45%of PACCs have alterations in the DNA damage repair pathway and 23%harbor rearrangements in the BRAF or RAF1 genes.We present a PACC case with a...
关键词：Pancreatic acinar carcinoma BRCA Polyadenosine diphosphate-ribose polymerase inhibitor Case report 
The potential role of albumin glycation by ribose in diabetes mellitus
《Science China(Life Sciences)》2022年第12期2552-2555,共4页Lixian Mou Xiao Cao Tao He Rongqiao He 
supported by the National Natural Science Foundation of China(31270868)。
Human serum albumin (HSA) is one of the most abundant plasma proteins and accounts for 50%–60%of total plasma proteins. HSA has various physiological and biochemical properties, undergoing different structural and co...
关键词：MELLITUS DIABETES POTENTIAL 
Determination of ribose and phosphorus contents in Haemophilus influenzae type b capsular polysaccharide by a quantitative NMR method using a single internal standard被引量：2
《Chinese Journal of Natural Medicines》2022年第8期633-640,共8页QIN Chun-Jun HU Jing TONG Wei ZHANG Teng-Teng TIAN Guang-Zong ZoU Xiao-Peng LIU Jian-Kai YIN Jian 
supported by the National Natural Science Foundation of China(Nos.22077052,21877052,21907039 and 22107037);the China Postdoctoral Science Foundation(Nos.2020M681487 and 2021M691279);the National Key R&D Program of China(No.2020YFA0908304);the Natural Science Foundation of Jiangsu Province(Nos.BK20180030 and BK20190575);the National First-class Discipline Program of Light Industry Technology and Engineering(No.LITE2018-14);the 111 Project(No.111-2-06);the Open Project of Key Laboratory of Carbohydrate Chemistry and Biotechnology(Jiangnan University),Ministry of Education(No.KLCCB-KF202005)。
The ribose and phosphorus contents in Haemophilus influenzae type b(Hib)capsular polysaccharide(CPS)are two important chemical indexes for the development and quality control of Hib conjugate vaccine.A quantitative ^(...
关键词：Haemophilus influenzae type b Capsular polysaccharide Quantitative^(1)H-NMR Quantitative^(31)P-NMR Ribose content Phosphorus content 
Accumulation of poly(adenosine diphosphate-ribose)by sustained supply of calcium inducing mitochondrial stress in pancreatic cancer cells
《World Journal of Gastroenterology》2022年第27期3422-3434,共13页Keun-Yeong Jeong Jae Jun Sim Minhee Park Hwan Mook Kim 
BACKGROUND The biochemical phenomenon defined as poly adenosine diphosphate(ADP)-ribosylation(PARylation)is essential for the progression of pancreatic cancer.However,the excessive accumulation of poly ADP-ribose(PAR)...
关键词：Pancreatic cancer CALCIUM Reactive oxygen species Poly adenosine diphosphate-ribose Poly adenosine diphosphate-ribosylation Poly adenosine diphosphate-ribose polymerase Apoptosis-inducing factor Nicotinamide adenine dinucleotide Anticancer effect 
聚ADP核糖聚合酶-1与原发性肝癌的研究进展
《临床医学进展》2022年第7期6893-6899,共7页阙克婷 刘作金 李钺 
最新统计数据表明,原发性肝癌(hepatocellular carcinoma, HCC)是世界上第二大致病率肿瘤,它有很高的复发率及很低的5年生存率,且它的治疗选择有限。然而每年的新发例数却在逐年增加。找到原发性肝癌复发、转移及耐药的机制是我们亟待...
关键词：聚ADP核糖聚合酶-1 (Poly(ADP)-Ribose Polymerase PARP1) 原发性肝癌(HCC) PARP抑制剂(PARPi) 
Recent advances in targeted therapy for ovarian cancer
《Oncology and Translational Medicine》2022年第1期28-35,共8页Tianyu Qin Gang Chen 
The global burden of ovarian cancer is gradually increasing while patients still suffer from relatively limited treatment options.With recent advances in the decoding of the molecular landscape of ovarian cancer,more ...
关键词：ovarian cancer targeted therapy ANTI-ANGIOGENESIS poly-(ADP)-ribose polymerase(PARP)inhibitor immune checkpoint inhibitor(ICI) clinical trial 
O-BODIPYs as fluorescent labels for sugars:glucose,xylose and ribose被引量：1
《Organic Chemistry Frontiers》2022年第3期720-730,共11页Deepika Kanyan Miriana Horacek-Glading Martijn J.Wildervanck Tilo Söhnel David C.Ware Penelope J.Brothers 
This work was supported by Marsden Fund grant UOA1521,administered by the Royal Society Te Apārangi.DK and MJW thank the Marsden Fund and MHG thanks the University of Auckland for the award of doctoral scholarships.The authors thank Dr Paul Hume and Associate Professors Mattie S.M.Timmer and Bridget L.Stocker(Victoria University of Wellington)for assistance with photophysical measurements and advice on NMR techniques.
Sugar-O-BODIPY conjugates,in which the fluorescent dye O-BODIPY is linked to sugars directly through B-O-C bonds,have been synthesized via an acid-catalyzed transesterification procedure.Conjugates of glucose,xylose a...
关键词：BODIPY SUGAR BONDS 
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