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Inhibiting Hv1 channel in peripheral sensory neurons attenuates chronic inflammatory pain and opioid side effects被引量：7
《Cell Research》2022年第5期461-476,共16页Qiansen Zhang Yimin Ren Yiqing Mo Peipei Guo Ping Liao Yuncheng Luo Jie Mu Zhuo Chen Yang Zhang Ya Li Linghui Yang Daqing Liao Jie Fu Juwen Shen Wei Huang Xuewen Xu Yanyan Guo Lianghe Mei Yunxia Zuo Jin Liu Huaiyu Yang Ruotian Jiang 
the National Natural Science Foundation of China(32071003 to R.J.);the Ministry of Science and Technology of China(2018ZX09711002 to Q.Z.);the National Natural Science Foundation of China(81873808 to Y.Z,31600832 to R.J.,31800699 to Q.Z.);the Fundamental Research Funds for the Central Universities(to H.Y.and 2018SCUH0086 to R.J.);the“XingFuZhiHua”funding of ECNU(44300-19311-542500/006 to H.Y.);the Department of Science and Technology of Sichuan Province(2020ZYD006 to R.J.);the 1-3-5 Project for Disciplines of Excellence of West China Hospital of Sichuan University(ZYJC21034 to R.J.).
Both opioids and nonsteroidal anti-inflammatory drugs(NSAIDS)produce deleterious side effects and fail to provide sustained relief in patients with chronic inflammatory pain.Peripheral neuroinflammation(PN)is critical...
关键词：SUSTAINED CHANNEL IMMUNITY 
Intracellular codelivery of anti-inflammatory drug and anti-miR 155 to treat inflammatory disease被引量：14
《Acta Pharmaceutica Sinica B》2020年第8期1521-1533,共13页Chao Teng Chenshi Lin Feifei Huang Xuyang Xing Shenyu Chen Ling Ye Helena S.Azevedo Chenjie Xu Zhengfeng Wu Zhongjian Chen Wei He 
supported by the National Natural Science Foundation of China(Nos.81872823 and 81773826);the Double First-Class(CPU2018PZQ13,China)of the China Pharmeutical University;the Ministry of Science and Technology of China(2018ZX09711001);the Shanghai Science and Technology Committee(19430741500,China);the Key Laboratory of Modern Chinese Medicine Preparation of Ministry of Education of Jiangxi University of traditional Chinese Medicine(TCM201905,China)
Atherosclerosis(AS) is a lipid-driven chronic inflammatory disease occurring at the arterial subendothelial space. Macrophages play a critical role in the initiation and development of AS. Herein,targeted codelivery o...
关键词：miR155 INFLAMMATORY SUSTAINED 
Sustained Akt signaling in articular chondrocytes causes osteoarthritis via oxidative stress-induced senescence in mice被引量：11
《Bone Research》2019年第3期318-326,共9页Jing Xie Jingting Lin Min Wei Yan Teng Qi He Guan Yang Xiao Yang 
supported by grants from the State Key Program of National Natural Science of China (31630093);the National Natural Science Foundation of China (31571512, 31871476, and 81241062);the Beijing Nova Program (Z161100004916146);the National Basic Research Program of China (2012CB966904)
Osteoarthritis(OA) is an age-related disorder that is strongly associated with chondrocyte senescence. The causal link between disruptive PTEN/Akt signaling and chondrocyte senescence and the underlying mechanism are ...
关键词：CHONDROCYTE ACCUMULATION of Osteoarthritis(OA) 
Alginate encapsulated mesoporous silica nanospheres as a sustained drug delivery system for the poorly water-soluble drug indomethacin被引量：2
《Asian Journal of Pharmaceutical Sciences》2014年第4期183-190,共8页Liang Hu Changshan Sun Aihua Song Di Chang Xin Zheng Yikun Gao Tongying Jiang Siling Wang 
This work was supported by National Basic Research Program of China(973 Program)(2009CB930300);National Natural Science Foundation of China(81072605);Shenyang Special Fund for Exploration of Intellectual Resources.
We applied a combination of inorganic mesoporous silica material,frequently used as drug carriers,and a natural organic polymer alginate(ALG),to establish a sustained drug delivery system for the poorly water-soluble ...
关键词：INDOMETHACIN Mesoporous silica nanospheres Aminepropyl group ALGINATE Sustained release Poorly water-soluble drug 
Incorporation of Carvedilol into PAMAM-functionalized MWNTs as a sustained drug delivery system for enhanced dissolution and drug-loading capacity
《Asian Journal of Pharmaceutical Sciences》2013年第5期278-286,共9页Xin Zheng Tianyi Wang Haitao Jiang Yuting Li Tongying Jiang Jinghai Zhang Siling Wang 
the National Basic Research Program of China(973 Program)(No.2009CB930300);National Natural Science Foundation of China(No.81273449).
The purpose of this study was to develop poly(amidoamine)(PAMAM)-functionalized multi-walled carbon nanotubes(MWNTs)loaded with a poorly water-soluble drug,intended to improve the drug-loading capacity,dissolution an...
关键词：PAMAM-MWNTs Drug delivery Drug-loading Improved dissolution Sustained release 
Sofosbuvir and ABT-450: Terminator of hepatitis C virus?被引量：6
《World Journal of Gastroenterology》2013年第21期3199-3206,共8页Qing-Lei Zeng Ji-Yuan Zhang Zheng Zhang Li-Feng Wang Fu-Sheng 
Supported by Grants from the National Key Basic Research Program of China, No. 2009CB522507, No. 2012CB519005;Beijing Nova Program of China, No. Z12110702512071
Combination therapy with peginterferon (pegIFN)-α and ribavirin (RBV) has been the standard of care (SOC) for chronic hepatitis C. Unfortunately, not all patients can achieve a sustained virologic response (SVR) with...
关键词：Sofosbuvir ABT-450 HEPATITIS C virus ANTIVIRAL therapy SUSTAINED VIROLOGIC response 
Distinct actions of intermittent and sustained β-adrenoceptor stimulation on cardiac remodeling被引量：16
《Science China(Life Sciences)》2011年第6期493-501,共9页MA XiaoWei1,3,SONG Yao1,3,CHEN Chao1,3,FU YongNan1,3,SHEN Qiang2,3,LI ZiJian1,3 & ZHANG YouYi1,3 1Institute of Vascular Medicine,Peking University Third Hospital,Beijing 100191,China 2Institute of Cardiovascular Science,Peking University,Beijing 100191,China 3Key Laboratory of Molecular Cardiovascular Sciences,Ministry of Education,Beijing 100191,China 
supported by theNational Basic Research Program of China (Grant No. 2011CB503903);the National Natural Science Foundation of China (Grant Nos.81030001 and 30971161);the International Cooperation and Exchange of the National Natural Science Foundation of China (Grant No.30910103902)
Heart disease is associated with increased sympathetic nerve activity and elevated levels of circulating catecholamines,resulting in chronic stimulation of the β-adrenergic receptors (β-AR) and consequent pathologic...
关键词：Β-ADRENOCEPTOR reactive oxygen species NADPH oxidase cardiac hypertrophy cardiac fibrosis 
Large Volume and High Density Surface Wave Plasmas Sustained by Two Microwave Launchers
《Chinese Physics Letters》2008年第5期1761-1763,共3页梁以资 欧琼荣 梁波 梁荣庆 
Surface wave plasma （SWP） is an electromagnetic excitation along the planar interface between a dielectric and plasma medium when plasma density is so large that its permittivity becomes negative. An experiment SWP ...
关键词：PLANAR PLASMA 
Roles of a sustained activation of NCED3 and the synergistic regulation of ABA biosynthesis and catabolism in ABA signal production in Arabidopsis被引量：12
《Chinese Science Bulletin》2007年第4期484-491,共8页REN HuiBo FAN YiJian GAO ZhiHui WEI KaiFa LI GuiFen LIU Jing CHEN Lin LI BingBing HU JianFang JIA WenSuo 
Supported by the National Basic Research Program of China (Grant No. 2003CB114300);the National Natural Science Foundation of China (Grant No. 30470160)
ABA, acting as a stress signal, plays crucial roles in plant resistance to water stress. Because ABA signal production is based on ABA biosynthesis, the regulation of NCED, a key enzyme in the ABA biosynthesis pathway...
关键词：拟南芥 ABA信号 ABA生物合成 分解代谢 协同调节 NCED3 持续致活 水胁迫 干旱 
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