ANDROSTANE

作品数：3被引量：9H指数：1
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A brief history of the discovery of PXR and CAR as xenobiotic receptors被引量：9
《Acta Pharmaceutica Sinica B》2016年第5期450-452,共3页Jiong Yan Wen Xie 
supported in part by the Joseph Koslow Endowed Professorship from the University of Pittsburgh School of Pharmacy
The nuclear receptors pregnane X receptor(PXR) and constitutive androstane receptor(CAR) were cloned and/or established as xenobiotic receptors in 1998.Due to their activities in the transcriptional regulation of phas...
关键词：PREGNANE X RECEPTOR Constitutive ANDROSTANE RECEPTOR XENOBIOTIC RECEPTORS CYP3A CYP2B CYP2B10 
Identification of CAR/RXR<i>α</i>Hetero-dimer Binding Sites in the Human Genome by a Modified Yeast One-Hybrid Assay
《Advances in Biological Chemistry》2015年第2期83-97,共15页Kenta Hosoda Yuichiro Kanno Masashi Sato Jun Inajima Yoshio Inouye Kazuyuki Yanai 
The constitutive androstane receptor (CAR) is a transcription factor that belongs to the nuclear receptor superfamily. CAR binds as a heterodimer with the retinoid X receptor α (RXRα) to CAR response elements (CAREs...
关键词：Constitutive ANDROSTANE RECEPTOR RETINOID X RECEPTOR Transcription SNP Polymorphism Nuclear RECEPTOR 
Effect of prototypical inducers on ligand activated nuclear receptor regulated drug disposition genes in rodent hepatic and intestinal cells
《Acta Pharmacologica Sinica》2010年第1期51-65,共15页Philip MARTIN Robert RILEY Paul THOMPSON Dominic WILLIAMS David BACK Andrew OWEN 
Aim： The aim of this study was to investigate the impact on expression of mRNA and protein by paradigm inducers/activators of nuclear receptors and their target genes in rat hepatic and intestinal cells. Furthermore,...
关键词：nuclear receptors hepatic cells intestinal cells prototypical inducers RODENTS DEXAMETHASONE pregnenolone 16α carbonitrile cytochrome P450 pregnane X receptor constituitive androstane receptor 
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