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RETINOID: 作品数：35被引量：59H指数：4; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：江和碧卓本慧瞿平李廷玉陈咏梅更多>>; 相关机构：重庆医科大学中国医学科学院北京协和医学院中国人民解放军总医院中国科学院更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金安徽省自然科学基金重庆市科委基金国家重点基础研究发展计划更多>>

Development of novel Gemini-cholesterol analogues for retinoid-related orphan receptors: 《Organic Chemistry Frontiers》2022年第6期1522-1530,共9页Uxía Gómez-Bouzó Alioune Fall Judit Osz Yagamare Fall ORCID logo Natacha Rochel Hugo Santalla; supported financially by the Xunta de Galicia(ED431C2017/70).; Retinoic-acid-related Orphan Receptors (RORs) regulate the maintenance of the circadian rhythm and immune response among others and are involved in increasing numbers of pathologies including autoimmune diseases, canc...; 关键词：ANALOGUES synthesis NUMBERS

Redox-sensitive micelles for targeted intracellular delivery and combination chemotherapy of paclitaxel and all-trans-retinoid acid被引量：3: 《Asian Journal of Pharmaceutical Sciences》2019年第5期531-542,共12页Lingfei Han Lejian Hu Fulei Liu XinWang Xiaoxian Huang Bowen Liu Feng Feng Wenyuan Liu Wei Qu; financially supported by the National Natural Science Foundation of China (Grant Nos. 81703382 and 81673567); The application of paclitaxel(PTX) in clinic has been restricted due to its poor solubility.Several traditional nano-medicines have been developed to improve this defect,while they are still lack of tumor targeting ab...; 关键词：Redox-sensitive Hyaluronic ACID All-trans-retinoid ACID Tumor targeting Combination chemotherapy

Effect of compound Yindan decoction on alpha-naphthylisothiocyanate-Induced acute intrahepatic cholestasis in rats被引量：3: 《Journal of Traditional Chinese Medicine》2019年第3期315-323,共9页Sun Fengxia Li Xiaoling Xu Chunjun Sui Jingli Li Pan Wu Jingjing; Supported by National Natural Science Foundation of China:Research on the mechanism of clearing away damp and heat and cooling and activating blood method based on the transcriptional regulation signaling pathway of hepatic membrane transport protein for the treatment of acute intrahepatic cholestasis(No.81573897); OBJECTIVE:To investigate the therapeutic mechanism of compound Yindan decoction (CYD) in a rat model of acute intrahepatic cholestatic (AIC).METHODS:A total of 108 adult male rats were randomly divided into control (n...; 关键词：Cholestasis intrahepatic MULTIDRUG resistance-associated proteins RETINOID X receptor alpha COMPOUND Yindan DECOCTION

Mechanisms of a Synthetic Retinoid in Inhibiting Tumor-Repopulating Cells: 《医用生物力学》2019年第A01期164-165,共2页Yao Zhang Qi Dong Junwei Chen Ning Wang; supported by funds from Huazhong University of Science and Technology; Recently we have synthesized a novel small retinoid molecule WYC-209 that can effectively inhibit proliferation of malignant murine melanoma tumor-repopulating cells(TRCs).The molecule can induce 100%TRCs apoptosis at...; 关键词：MECHANISMS a SYNTHETIC RETINOID INHIBITING Tumor-Repopulating Cells

Retinoid receptor-related orphan receptor alpha： a key gene setting brain circuits被引量：1: 《Neural Regeneration Research》2018年第5期791-794,共4页Tania Vitalis Jean Mariani; supported by the Institut National de la Santéet de la Recherche Médicale and the Centre National de la Recherche Scientifique; The retinoid receptor-related orphan receptor alpha（RORα） is thought to act as a constitutive activator of transcription by binding to the ROR response element（RORE） of target genes. Several mouse models in which...; 关键词：CEREBELLUM cerebral cortex development MATURATION NEUROPROTECTION psychiatric disorders somatosensory system

Protective Effect of Norcantharidin on Collagen-Induced Arthritis Rats被引量：9: 《Chinese Journal of Integrative Medicine》2018年第4期278-283,共6页SHEN Hong-bo HUO Ze-jun BAI Yun-jing HE Xiao-juan LI Chang-hong ZHAO Yu-kun GUO Qing-qing; Supported by the National Natural Science Foundation of China(No.81273837); Objective： To observe the effect of norcantharidin（NCTD） on collagen-induced arthritis（CIA） rats. Methods： Sixty Sprague-Dawley（SD） rats were randomly divided into 6 groups（n=10）： normal group, CIA model gr...; 关键词：NORCANTHARIDIN collagen-induced arthritis CYTOKINE TH17/TREG forkhead box P3 retinoid related orphan nuclear receptor γt

Expression of E2A in Mid-secretory Endometrium of Women Suffering from Recurrent Miscarriage: 《Journal of Huazhong University of Science and Technology(Medical Sciences)》2017年第6期910-914,共5页尹智囊丁锦丽张怡李赛姣张艳杨菁; supported by the grants from National Natural Science Foundation of China(No.81401276,No.81771618 and No.81771662);the Fund Project of Health and Family Planning Commission of Hubei Province(No.WJ2015MA006 and No.WJ2015Q017); E2A is involved in promoting forkhead box P3（FOXP3） and retinoid-related orphan receptor gamma t（RORγt） gene transcription, which are pivotal transcription factors of T regulatory cells and Th17 cells, respective...; 关键词：E2A cytotoxic T-lymphocyte-associated protein 4 forkhead box P3 retinoid-related orphan receptor gamma t recurrent miscarriage

Role of retinoids in the prevention and treatment of colorectal cancer被引量：2: 《World Journal of Gastrointestinal Oncology》2015年第10期184-203,共20页Catherine C Applegate Michelle A Lane; Vitamin A and its derivatives, retinoids, have been widely studied for their use as cancer chemotherapeutic agents. With respect to colorectal cancer(CRC), several critical mutations dysregulate pathways implicated in...; 关键词：COLORECTAL cancer RETINOID VITAMIN A β-catenin Pho

Identification and Characterization of Human Genomic Binding Sites for Retinoic Acid Receptor/Retinoid X Receptor Heterodimers: 《Advances in Biological Chemistry》2015年第2期58-72,共15页Kenta Hosoda Masashi Sato Kazuyuki Yanai; All-trans retinoic acid (ATRA) triggers a wide range of effects on vertebrate development by regulating cell proliferation, differentiation, and apoptosis. ATRA activates retinoic acid receptors (RARs) which heterodim...; 关键词：ALL-TRANS RETINOIC ACID RETINOIC ACID RECEPTOR RETINOID X RECEPTOR Yeast One-Hybrid System Polymorphism Regulatory SNP

Identification of CAR/RXR<i>α</i>Hetero-dimer Binding Sites in the Human Genome by a Modified Yeast One-Hybrid Assay: 《Advances in Biological Chemistry》2015年第2期83-97,共15页Kenta Hosoda Yuichiro Kanno Masashi Sato Jun Inajima Yoshio Inouye Kazuyuki Yanai; The constitutive androstane receptor (CAR) is a transcription factor that belongs to the nuclear receptor superfamily. CAR binds as a heterodimer with the retinoid X receptor α (RXRα) to CAR response elements (CAREs...; 关键词：Constitutive ANDROSTANE RECEPTOR RETINOID X RECEPTOR Transcription SNP Polymorphism Nuclear RECEPTOR

RETINOID