云南高校图书馆联盟文献共享服务平台- PREGNANE

PREGNANE: 作品数：12被引量：36H指数：4; 导出分析报告; 相关作者：吴琼吴再旺邢鹏鹏付宏征王梅更多>>; 相关机构：北京大学广州医科大学更多>>; 相关期刊：《中国免疫学杂志》《Journal of Chinese Pharmaceutical Sciences》《Chinese Journal of Chemistry》《Journal of Integrative Plant Biology》更多>>; 相关基金：国家自然科学基金更多>>

The 3’-untranslated region contributes to the pregnane X receptor(PXR) expression downregulation by PXR ligands and up-regulation by glucocorticoids被引量：1: 《Acta Pharmaceutica Sinica B》2020年第1期136-152,共17页Tomas Smutny Jan Dusek Lucie Hyrsova Jana Nekvindova Alzbeta Horvatova Stanislav Micuda Sabine Gerbal-Chaloin Petr Pavek; supported by grants from the Czech Science Foundation 17-06841S to Petr Pavek;EFSA-CDN(No.CZ.02.1.01/0.0/0.0/16_019/0000841,Czech Republic)co-funded by ERDF to Tomas Smutny.; Pregnane X receptor(PXR)is the major regulator of xenobiotic metabolism.PXR itself is controlled by various signaling molecules including glucocorticoids.Moreover,negative feed-back regulation has been proposed at the...; 关键词：Gene EXPRESSION MicroRNA GLUCOCORTICOID Regulation PREGNANE X receptor CYTOCHROME P4503A4

Role of pregnane X-receptor in regulating bacterial translocation in chronic liver diseases被引量：4: 《World Journal of Hepatology》2017年第32期1210-1226,共17页Sundhar Mohandas Balasubramaniyan Vairappan; Bacterial translocation(BT) has been impeccably implicated as a driving factor in the pathogenesis of a spectrum of chronic liver diseases(CLD). Scientific evidence accumulated over the last four decades has implied t...; 关键词：Pregnane X receptor Bacterial translocation Chronic liver disease Intestinal permeability INFLAMMATION Tight junctions

激活核受体PXR促进小鼠GM-CSF来源的树突状细胞的分化: 《中国免疫学杂志》2016年第11期1593-1597,共5页邱怀娜查贺飞曲佳乐王梅李璐齐艳伟黄俊杨权(指导); 广州医科大学科学科研项目资助(2015C01); 目的:研究孕烷受体(PXR)激动剂pregnane-16α-carbonitrile(PCN)对小鼠GM-CSF来源树突状细胞(DC)分化的影响。方法:建立小鼠DC体外GM-CSF和IL-4诱导分化体系,并用PCN对体系进行处理。流式细胞术检测CD11c+DC的比例;ELISA和流式细胞术检...; 关键词：树突状细胞分化 PREGNANE X RECEPTOR NOTCH信号通路 WNT信号通路

PXR variants:the impact on drug metabolism and therapeutic responses被引量：5: 《Acta Pharmaceutica Sinica B》2016年第5期441-449,共9页C.Trent Brewer Taosheng Chen; supported by the American Lebanese Syrian Associated Charities (ALSAC),St.Jude Children0s Research Hospital;the U.S. National Institutes of Health (Grants GM086415,GM110034,GM118041 and P30-CA21765); The pregnane X receptor(PXR) plays an important and diverse role in mediating xenobiotic induction of drug-metabolizing enzymes and transporters.Several protein isoforms of PXR exist,and they have differential transcr...; 关键词：PREGNANE X receptor TRANSCRIPT VARIANTS Drug metabolism THERAPEUTIC responses TOXICITY

A brief history of the discovery of PXR and CAR as xenobiotic receptors被引量：9: 《Acta Pharmaceutica Sinica B》2016年第5期450-452,共3页Jiong Yan Wen Xie; supported in part by the Joseph Koslow Endowed Professorship from the University of Pittsburgh School of Pharmacy; The nuclear receptors pregnane X receptor(PXR) and constitutive androstane receptor(CAR) were cloned and/or established as xenobiotic receptors in 1998.Due to their activities in the transcriptional regulation of phas...; 关键词：PREGNANE X RECEPTOR Constitutive ANDROSTANE RECEPTOR XENOBIOTIC RECEPTORS CYP3A CYP2B CYP2B10

Pregnane receptor gene polymorphisms,pathogenic bacteria distribution and drug sensitivity,and TCM dyndrome differentiation in patients with cholelithiasis被引量：7: 《Asian Pacific Journal of Tropical Medicine》2016年第4期301-305,共5页Yi-Qiang Xie Jing-Zhe Zhang Hua Zhang Lei Peng Shuang Zhou Li-Zhuo Li Bang-Jiang Fang Chuan-Zhu Lyu; supported by the National Science Foundation of China(30672698). "The first two authors contributed equally to this work; Objective:To investigate the distribution of pathogens and drug resistance in bile and the association between the pregane X receptor(PXR) gene polymorphisms,traditional Chinese medicine(TCM) syndromes and the risk of...; 关键词：CHOLELITHIASIS CHOLESTEROL GALLSTONE disease Drug resistance test Pregane X receptor Polymorphism Traditional Chinese medicine SYNDROMES

Microcantilever-based Nanomechanical Studies of the Orphan Nuclear Receptor Pregnane X Receptor-Ligand Interactions: 《Journal of Biomaterials and Nanobiotechnology》2011年第2期133-142,共10页Kasey L. Hill Pampa Dutta Zhou Long Michael J. Sepaniak; Human pregnane X receptor (PXR) is of vital importance in pharmaceutical and exogenous compound metabolism within the body. This provides strong motivation for investigating this orphan receptor’s activation by vario...; 关键词：MICROCANTILEVERS Nanobiosensing PREGNANE X RECEPTOR ESTROGEN RECEPTOR ENDOCRINE disrupting chemicals Bioarray

A new pregnane-type glycoside from Reineckia carnea被引量：2: 《Journal of Chinese Pharmaceutical Sciences》2011年第4期347-351,共5页邢鹏鹏吴琼吴再旺付宏征; National Natural Science Foundation of China (Grant No.30973628); The aim of current study was to investigate the chemical components of the aerial part of Reineckia carnea,collected in Yunnan Province of China.Repeated column chromatography（CC）separations were performed to isolat...; 关键词：Reineckia carnea Steroid saponin SAPONIN

A New Pregnane from Munronia delavayi Franc （Meliaceae）被引量：5: 《Journal of Integrative Plant Biology》2006年第9期1126-1128,共3页Xiang-Hai Cai Xiao-Dong Luo Jun Zhou Xiao-Jiang Hao; To search for pharmacologically active constituents of folk medicine, a new pregnane, 2α,3α,15β-trihydroxy-20（S）-tigloyl-pregnane （compound 1）, and nine known compounds, geranylgeraniol （compound 2）, β-dauco...; 关键词：chemical constituents MELIACEAE Munronia delavayi PREGNANE 2α 3α 15β-trihydroxy-20（S）-tigloyl-pregnane

Purification of full-length human Pregnane and Xenobiotic Receptor:polyclonal antibody preparation for immunological characterization被引量：1: 《Cell Research》2005年第10期785-795,共11页Mallampati SARADHI Biji KRISHNA Gauranga MUKHOPADHYAY Rakesh K TYAGI; Pregnane and Xenobiotic Receptor (PXR; or Steroid and Xenobiotic Receptor, SXR), a new member of the nuclear receptor superfamily, is thought to modulate a network of genes that are involved in xenobiotic metabolism a...; 关键词：Pregnane and Xenobiotic Receptor Steroid and Xenobiotic Receptor prokaryotic expression polyclonal antibody isoforms.

PREGNANE