ADAPTOR

作品数：33被引量：102H指数：5
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相关领域：医药卫生生物学更多>>
相关作者：欧阳翔赵明文李玉祥吴婧丁一新更多>>
相关机构：南京农业大学佛山市南海旭胜包袋有限公司中国热带农业科学院海南大学更多>>
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相关基金：国家自然科学基金江苏省自然科学基金中国博士后科学基金福建省自然科学基金更多>>
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A phase separation-fortified bi-specific adaptor for conditional tumor killing
《Science China(Life Sciences)》2024年第7期1385-1397,共13页Yuyan Liu Yuting Zhu Weifan Xu Pilong Li 
supported by the National Natural Science Foundation of China(32150023)。
A common approach in therapeutic protein development involves employing synthetic ligands with multivalency,enabling sophisticated control of signal transduction.Leveraging the emerging concept of liquid-liquid phase ...
关键词：phase separation therapeutic proteins receptor-ligand interactions DR5 tumor apoptosis 
Identification of neutral genome integration sites with high expression and high integration efficiency in Fusarium venenatum TB01
《Synthetic and Systems Biotechnology》2023年第1期141-147,共7页Sheng Tong Kexin An Wuxi Chen Mengdan Chai Yuanxia Sun Qinhong Wang Demao Li 
supported by the Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project (TSBICIP-CXRC-050 and TSBICIP-KJGG-004-20);the China Postdoctoral Science Foundation (2022M713329).
CRISPR/Cas9-mediated homology-directed recombination is an efficient method to express target genes.Based on the above method,providing ideal neutral integration sites can ensure the reliable,stable,and high expressio...
关键词：GFP expression library Neutral integration site Y-shaped adaptor-dependent extension CRISPR/Cas9 Fusarium venenatum 
The Roles and Mechanisms of TRAT1 in the Progression of Non-Small Cell Lung Cancer
《Current Medical Science》2022年第6期1186-1200,共15页Qiang GUO Si-hua WANG Yan-mei JI Song TONG Dan LI Xiang-chao DING Chuang-yan WU 
supported by grants from the Natural Science Foundation of Hubei(No.2020CFB392);the National Natural Science Foundation of China(No.82100115,No.82100116 and No.82070431).
Objective T cell receptor-associated transmembrane adaptor 1(TRAT1)is one of the hub genes regulating T cell receptors(TCRs).Herein,the roles of TRAT1 in the prognosis and immune microenvironment of non-small cell lun...
关键词：T cell receptor-associated transmembrane adaptor 1 non-small cell lung cancer immune infiltration prognosis T cell receptors 
A simple,low-cost 3D printed adaptor for endoillumination in intraocular surgery
《International Journal of Ophthalmology(English edition)》2022年第7期1207-1208,共2页Xu-Long Liao Pei-Min Lin Hao-Yu Chen 
Supported by Shantou Science and Technology Program(No.200629165261641);2020 Li Ka Shing Foundation Cross-Disciplinary Research Grant(No.2020LKSFG14B)。
Dear Editor,The application of three-dimensional (3D) printing techniques in ophthalmology enables cost-effective design and production of custom medical instruments.Complications of cataract surgery,such as a dropped...
关键词：ILLUMINATION COST PRINTING 
Therapeutic effect of Qinghuayin(清化饮)against chronic atrophic gastritis through the inhibition of toll or interleukin-1 receptor domain-containing adaptor inducing interferon-β signaling pathway被引量：5
《Journal of Traditional Chinese Medicine》2022年第2期221-226,共6页HE Youcheng YAO Xiaoling LI Sihan ZHOU Hongjian XU Ruoying ZHENG Rong XIAO Wendi SU Ning LIN Ping HUANG Minghan 
Supported by Natural Science Foundation of Fujian Province(Based on NLRP3 Inflammatory Body/Caspase-1-mediated Gastric Epithelial Cell Death to Explore the Molecular Mechanism of Qinghua Decoction in the Treatment of Chronic Atrophic Gastritis,No.2020J01253)。
OBJECTIVE:To examine the efficacy of Qinghuayin(清化饮,QHY)in rat chronic atrophic gastritis(CAG)models and explored the molecular mechanism of QHY in treating CAG.METHODS:In total,65 Wistar rats were randomly divided...
关键词：gastritis atrophic toll-like receptor 4 interleukin-6 interleukin-8 toll or interleukin-1 receptor domain-containing adaptor inducing interferon-β Qinghuayin 
Rapid GFAP and Iba1 expression changes in the female rat brain following spinal cord injury被引量：3
《Neural Regeneration Research》2022年第2期378-385,共8页Mawj Mandwie Jordan A.Piper Catherine A.Gorrie Kevin A.Keay Giuseppe Musumeci Ghaith Al-Badri Alessandro Castorina 
The University of Technology Sydney(UTS)Start-up Research Grant 2018 funded this study(to AC)。
Evidence suggests that rapid changes to supporting glia may predispose individuals with spinal cord injury(SCI) to such comorbidities. Here, we interrogated the expression of astrocyte-and microglial-specific markers ...
关键词：affective disorders ASTROCYTES glial fibrillary acidic protein ionized calcium binding adaptor molecule 1 memory MICROGLIA NEUROTRAUMA spinal cord injury 
Toll-like receptor 3(TLR3)regulation mechanisms and roles in antiviral innate immune responses被引量：15
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2021年第8期609-632,共24页Yujuan CHEN Junhong LIN Yao ZHAO Xianping MA Huashan YI 
supported by the National Key R&D Program of China(No.2018YFD0501705);the Chongqing Basic Research Program(No.cstc2018jcyj AX0615);the Fundamental Research Funds for the Central Universities(Nos.XDJK2018C059 and XDJK2018C060),China。
Toll-like receptor 3(TLR3)is a member of the TLR family,mediating the transcriptional induction of type I interferons(IFNs),proinflammatory cytokines,and chemokines,thereby collectively establishing an antiviral host ...
关键词：Toll-like receptor 3(TLR3) Toll-interleukin-1 receptor(TIR)-domain-containing adaptor-inducing interferon-β(TRIF) Innate immune Antiviral response 
Effect of acetyl-L-carnitine on hypersensitivity in acute recurrent caerulein-induced pancreatitis and microglial activation along the brain’s pain circuitry被引量：4
《World Journal of Gastroenterology》2021年第9期794-814,共21页Sabrina L McIlwrath Marlene E Starr Abigail E High Hiroshi Saito Karin N Westlund 
United States Department of Veterans Affairs,VA Merit Grant,No.BX002695;United States National Institute of Health,No.R01AG055359,No.R01GM126181 and No.R01NS39041-15.
BACKGROUND Acute pancreatitis(AP)and recurring AP are serious health care problems causing excruciating pain and potentially lethal outcomes due to sepsis.The validated caerulein-(CAE)induced mouse model of acute/recu...
关键词：Acute recurrent pancreatitis Neuropathic pain Mechanical hypersensitivity Heat hypersensitivity Anxiety-like behavior Ionized calcium-binding adaptor molecule 1 
A Peptide Binder of E3 Ligase Adaptor SPOP Disrupts Oncogenic SPOP-Protein Interactions in Kidney Cancer Cells
《Chinese Journal of Chemistry》2021年第2期274-280,共7页Zhen Wang Hao Zhang Baoen Chen Sisheng Ouyang Tong Zheng Ran Zhou Ze Dong Yue Huang Tao Zhang Hualiang Jiang Jianhua Gan Cheng Luo Cai-Guang Yang 
This work was supported by the National Natural Science Foundation of China(No.21725801 to C.-G.Y,Nos.81625022 and 81430084 to C,L,and No.21807103 to 2.D.);the National Key New Urug Lreation and Manufacturing Program,Ministry of Science and Technology(No.20182X09711002 to Z.D.);the Science and Technology Commis-sion of Shanghal munltlpallty(NB.18YF1428500 to Y.H.alu Nu..18431907100 to H.J.J;the China Postdoctoral Science Foun-dation(No.2018M640434 to Y.H.,No.2017M621570 to Z.D.,and Nu.2018M032187 lwT.L).
The E3 ligase adaptor SPOP,overexpressed in the nucleus but frequently dislocated into the cytoplasm in all clear cell Renal Cell Carcinomas(ccRCC),serves as a regulatory hub to promote kidney cancer through the ubiqu...
关键词：SPOP Protein-protein interaction Clear cell Renal Cell Carcinomas Crystal structure Peptide inhibitor 
IPL adaptor技术探析
《电子测试》2020年第16期16-17,共2页游智超 
IPL医学光疗美容产品随着社会需求的发展,已经由医院专有设备慢慢转为家庭患者居家便携使用。该课题是探析一款全新IPL配套的adaptor便捷适配器电源技术.该电源符合医疗器械配套电源IEC/UL 60601-1安规要求,且符合IPL应用的特殊性,架构...
关键词：IPL 医疗器械配套电源 便携式 创新 
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