TIMOSAPONIN

作品数：6被引量：29H指数：3
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相关领域：医药卫生生物学更多>>
相关期刊：《Chinese Journal of Natural Medicines》《Acta Pharmacologica Sinica》《中国药理学与毒理学杂志》更多>>
相关基金：国家自然科学基金更多>>
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Antiangiogenesis effect of timosaponin AⅢ on HUVECs in vitro and zebrafish embryos in vivo被引量：5
《Acta Pharmacologica Sinica》2020年第2期260-269,共10页Zhong-yan Zhou Wai-rong Zhao Ying Xiao Xiang-ming Zhou Chen Huang Wen-ting Shi Jing Zhang Qing Ye Xin-lin Chen Jing-yi Tang 
the Shanghai University of Traditional Chinese Medicine(Al-U17205010301);the National Health Commission of Shanghai(GWIV-28,ZY-(2018-2020)-FWTX-8001);the National Natural Science Foundation of China(81603549,81673726,and 81760860)。
Timosaponin AIII(Timo AIII)is a natural steroidal saponin isolated from the traditional Chinese herb Anemarrhena asphodeloides Bge with proved effectiveness in the treatment of numerous cancers.However,whether Timo AI...
关键词：TIMOSAPONIN AIII Traditional Chinese HERBAL NEOVASCULARIZATION NEOPLASM VEGF/PI3K/Akt/MAPK Transcriptome Zebrafish HUVECS SU5416 
Metabolism, pharmacokinetics, and hepatic disposition of xanthones and saponins on Zhimu treatments for exploratively interpreting the discrepancy between the herbal safety and timosaponin A3-induced hepatotoxicity被引量：3
《Acta Pharmacologica Sinica》2018年第12期1923-1934,共12页Yang Xie Xu Zhou Hu Pei Ming-cang Chen Zhao-lin Sun Ya-ru Xue Xiao-ting Tian Cheng-gang Huang 
The National Natural Science Foundation of China (Nos.81030065and 81374052);National Natural Science Foundation for Young Scientistsof China (Nos.81603280and 81602998); Strategic Priority Program of Chinese Academy of Sciences(No.XDA12040203).
Timosaponin A3, a saponin in Zhimu, elicited hepatotoxicity via oxidative stress. However, the clinical medication of Zhimu has been historically regarded as safe, probably associated with the antioxidants it contains...
关键词：Zhimu TIMOSAPONIN A3 MANGIFERIN PHARMACOKINETICS METABOLISM HEPATOTOXICITY antioxidant 
Two new steroidal saponins isolated from Anemarrhena asphodeloides被引量：2
《Chinese Journal of Natural Medicines》2017年第3期220-224,共5页SUN Xing-Huan ZHU Fu-Tao ZHANG Yu-Wei CHEN Fang-Fang YU Yun SONG Ning-Ning HUANG Xue-Feng 
supported by the National Natural Science Foundation of China(No.81573560);the National Training Programs of Innovation and Entrepreneurship for Undergraduates(No.G12123)
Two new steroidal saponins,named timosaponin P(1) and timosaponin Q(2),were isolated from the rhizome parts of Anemarrhena asphodeloides Bunge using various chromatographic methods.Their structures and absolute config...
关键词：Anemarrhena asphodeloides Timosaponin P Timosaponin Q ECD Steroidal saponin Absolute configuration 
Timosaponin derivative YY-23 acts as a non- competitive NMDA receptor antagonist and exerts a rapid antidepressant-like effect in mice被引量：6
《Acta Pharmacologica Sinica》2016年第2期166-176,共11页QiZHANG Fei GUO Zhi-wen FU Bing ZHANG Cheng-gang HUANG Yang LI 
This work was supported by the National Natural Science Foundation （31128009 and 31171011 to Yang LI）, the National Science ＆ Technology Major Project ＇Key New Drug Creation and Manufacturing Program＇ （2014ZX09102-001-005 to Chenggang HUANG）, and the Ministry of Science and Technology （2013CB910601 to Yang LI）.
Aim： N-methyI-D-aspartic acid （NMDA） receptor modulators have shown promising results as potential antidepressant agents, whereas timosaponins extracted from the Chinese herb Rhizoma Anemarrhenae exhibit antidepres...
关键词：Rhizoma Anemarrhenae TIMOSAPONIN YY-23 DEPRESSION NMDA receptor antagonist chronic mild stress chronic socialdefeat stress FLUOXETINE 
Inhibition of NMDA receptor and GSK3β vmediates the fast onset of antidepressant like natural product
《中国药理学与毒理学杂志》2015年第S1期48-48,共1页QiZHANG FeiGUO Zhi-WenFU BingZHANG Cheng-GangHUANG YangLI 
The project supported by the National Natural Science Foundation(31128009,31171011);the National Science&Technology Major Project″Key New Drug Creation and Manufacturing Program″(2014ZX09102-001-005);the Ministry of Science and Technology(2013CB910601)
OBJECTIVE To investigate the fast antidepressant effect and the underlying mechanism of it.METHODS C57BL/6 mice were exposed to a 6-week chronic unpredictable mild stress(CUMS)protocol,and treated with YY-23 or a posi...
关键词：NATURAL product TIMOSAPONIN DEPRESSION antidepress 
Timosaponin A3 induces hepatotoxicity in rats through inducing oxidative stress and down-regulating bile acid transporters被引量：15
《Acta Pharmacologica Sinica》2014年第9期1188-1198,共11页Zhi-tao WU Xin-ming QI Jing-jing SHENG Lei-lei MA Xuan NI Jin REN Cheng-gang HUANG Guo-yu PAN 
Aim： To investigate the mechanisms underlying the hepatotoxicity of timosaponin A3 （TA3）, a steroidal saponin from Anemarrhena asphodeloides, in rats. Methods： Male SD rats were administered TA3 （100 mg.kg^-1·d^...
关键词：timosaponin A3 HEPATOTOXICITY cholestasis bile acid transporter CYP7A1 ROS N-acety -L-cysteine mangiferin 
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