PUNICALAGIN

作品数：10被引量：57H指数：4
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相关领域：医药卫生更多>>
相关机构：中国科学技术大学更多>>
相关期刊：《Science China(Life Sciences)》《Chinese Journal of Natural Medicines》《Acta Pharmacologica Sinica》《Journal of Integrative Agriculture》更多>>
相关基金：国家科技支撑计划国家自然科学基金国家重点基础研究发展计划更多>>
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Punicalagin alleviates hypercholesterolemia in mice through modulating farnesoid X receptor signaling and modulating gut microbiota
《Food Science and Human Wellness》2025年第1期175-189,共15页Huanhuan Liu Hongli Liu Chunhong Yan Jiaxiu Liu Yu Cao Guopeng Li Xiaodong Xia 
supported in part by the National Key Research and Development Program of China(2022YFD2100104);the Science and Technology Program of Shaanxi Province,China(2022JM-111);Graduate Innovation Fund of Dalian Polytechnic University。
Punicalagin has been demonstrated to exhibit anti-oxidant and anti-inflammatory properties,but whether and how it could impact hypercholesterolemia remains not fully explored.The aim of this study was to investigate t...
关键词：PUNICALAGIN HYPERCHOLESTEROLEMIA Farnesoid X receptor Bile acid metabolism Gut microbiota 
The PGAM5eNEK7 interaction is a therapeutic target for NLRP3 inflammasome activation in colitis
《Acta Pharmaceutica Sinica B》2025年第1期349-370,共22页Cheng-Long Gao Jinqian Song Haojie Wang Qinghong Shang Xin Guan Gang Xu Jiayang Wu Dalei Wu Yueqin Zheng Xudong Wu Feng Zhao Xindong Liu Lei Shi Tao Pang 
supported by the National Natural Science Foundation of China(82174010 and 81973512);the Open Fund of the State Key Laboratory of Pharmaceutical Biotechnology,Nanjing University(Grant No.KF-202206,China);the Double First-Class Project of China Pharmaceutical University(CPUQNJC22_02,China)。
The innate immune sensor NLRP3 inflammasome overactivation is involved in the pathogenesis of ulcerative colitis.PGAM5 is a mitochondrial phosphatase involved in NLRP3 inflammasome activation in macrophages.However,th...
关键词：PGAM5 APEX2proximity labeling Protein-protein interaction NEK7 NLRP3 inflammasome PUNICALAGIN 
Punicalagin prevents obesity-related cardiac dysfunction through promoting DNA demethylation in mice
《Food Science and Human Wellness》2024年第3期1465-1474,共10页Shengjie Pei Run Liu Qingqing Ma Peng Jiang Xin He Zhongshi Qi Jiacheng Fang Xu Yang Zirui Yao Xiaoqian Liu Xianfeng Jing Lei Chen Duo Li 
supported by the Natural Science Foundation of Shandong Province (ZR2020QH294 and ZR2021QH342)。
The aim of this study was to investigate whether punicalagin(PU)could prevent obesity-related cardiac dysfunction by promoting DNA demethy lation,and to explore its possible mechanism.C57BL/6J mice were fed with stand...
关键词：DNA demethylation Mitochondrial function Obesity-related cardiac dysfunction PUNICALAGIN Ten-eleven translocation family enzymes 
Punicalagin ameliorates collagen-induced arthritis by downregulating M1 macrophage and pyroptosis via NF-κB signaling pathway被引量：30
《Science China(Life Sciences)》2022年第3期588-603,共16页Gaoran Ge Jiaxiang Bai Qing Wang Xiaolong Liang Huaqiang Tao Hao Chen Minggang Wei Junjie Niu Huilin Yang Yaozeng Xu Yuefeng Hao Yi Xue Dechun Geng 
supported by the National Natural Science Foundation of China(82072425,82072498,81902181,81873990,81873991,and 81672238);the Jiangsu Provincial Medical Youth Talent(QNRC2016751);the Natural Science Foundation of Jiangsu Province(BK20180001);the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD);the Special Project of Diagnosis and Treatment Technology for Key Clinical Diseases in Suzhou(LCZX202003);the Program for Introduction of Clinical Medical Teams to Suzhou(SZYJTD201714);Program from Suzhou Science and Technology Bureau(SYS2019101)。
Rheumatoid arthritis(RA)is a chronic inflammatory disease that eventually leads to disability.Inflammatory cell infiltration,severe joint breaking and systemic bone loss are the main clinical symptoms.In this study,we...
关键词：rheumatoid arthritis POMEGRANATE M1 macrophage PYROPTOSIS 
In vitro and in vivo antioxidant activities of three major polyphenolic compounds in pomegranate peel: Ellagic acid, punicalin, and punicalagin被引量：8
《Journal of Integrative Agriculture》2017年第8期1808-1818,共11页SUN Yu-qing TAO Xin MEN Xiao-ming XU Zi-wei WANG Tian 
supported by the Science and Technology Department of Zhejiang Province, China (2012C12906-4);the Modern Agro-industry Technology Research System of China (CARS-36);the National Key Technology R&D Program, China (2012BAD39B03-4);Agro-scientific Research in the Public Interest, China (201403047)
Pomegranates is abundant in polyphenols and is well-known for its antioxidant activity. Punicalagin （PG） is a major poly- phenolic compound in the pomegranate peel. In certain conditions, PG can be hydrolyzed to pun...
关键词：ellagic acid punicalin PUNICALAGIN ANTIOXIDANT oxidative stress 
Punicalagin protects bovine endometrial epithelial cells against lipopolysaccharide-induced inflammatory injury被引量：10
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2017年第6期481-491,共11页An LYU Jia-jia CHEN Hui-chuan WANG Xiao-hong YU Zhi-cong ZHANG Ping GONG Lin-shu JIANG Feng-hua LIU 
supported by the National Key Technology R&D Program of China(No.2013BAD10B04);the Importation and Development of High-Caliber Talents Project of Beijing Municipal Institutions(No.CIT&TCD20130324),China
Objective：Bovine endometritis is one of the most common reproductive disorders in cattle.The aim of this study was to investigate the anti-inflammation potential of punicalagin in lipopolysaccharide（LPS）-induced bo...
关键词：Bovine endometrial epithelial cell CYTOKINE Inflammatory injury PUNICALAGIN 
Potential role of punicalagin against oxidative stress nduced testicular damage被引量：6
《Asian Journal of Andrology》2016年第4期627-632,共6页Faiza Rao Hui Tian Wenqing Li Helong Hung Fei Sun 
This work was supported by National Natural Science Foundation of China Grants 81125005 and 81430027 （to F.S.）, the National Basic Research Program of China （2014CB943100）.
Punlcalagin is isolated from pomegranate and widely used for the treatment of different diseases in Chinese traditional medicine. This study aimed to evaluate the effect of Punicalagin （purity L〉98%） on oxidative s...
关键词：FERTILITY oxidative stress PUNICALAGIN sperm parameters testicular damage 
Antioxidant Activity of Pomegranate Juice and Punicalagin被引量：3
《Natural Science》2016年第6期235-246,共12页Akram Aloqbi Ulfat Omar Marwa Yousr Mary Grace Mary Ann Lila Nazlin Howell 
Plant polyphenols are reported to have bioactive properties, which may be used for protection against diseases. Therefore, the aim of this research was to investigate the antioxidant activities of a pomegranate tannin...
关键词：HPLC LC-MS PUNICALAGIN Radical Scavenger Ferrous Ion Chelating 
Punicalagin induces apoptotic and autophagic ce death in human U87MG glioma cells
《Acta Pharmacologica Sinica》2013年第11期1411-1419,共9页Shyang-guang WANG Ming-hung HUANG Jui-hsiang LI Fu-i LAI Horng-mo LEE Yuan-nian HSU 
Aim： To investigate the effects of punicalagin, a polyphenol isolated from Punica granatum, on human U87MG glioma cells in vitro. Methods： The viability of human U87MG glioma cells was evaluated using MTT assay. Cel...
关键词：PUNICALAGIN human glioma autophagy apoptosis microtubule-associated protein light chain 3 AMPK P27 z-DEVD-fmk CHLOROQUINE 
Punica granatum果实皮甲醇提取物化学成分的分离和标准化(英文)
《中国天然药物》2011年第6期414-420,共7页Vishal Jain Murugananthan G Deepak M GL Viswanatha D Manohar 
AIM:The present study was undertaken to isolate and standardize the various active phytochemical constituents present in the fruit rinds of Punica granatum.METHODS:Fruit rinds of Punica granatum were dried and extract...
关键词：Punica granatum Punicalin PUNICALAGIN Gallic acid and ellagic acid 
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