the National Natural Science Foundation of China(Nos.22177089,21721005,92153303,22037004,22177088);the Fundamental Research Funds for the Central Universities(2042021kf0211);Translational Medicine and Interdisciplinary Research Joint Fund of Zhongnan Hospital of Wuhan University(Grant No.ZNJC202309).
DNA 5-formylcytosine(5fC)is a prominent epigenetic modification within biological systems.Recent investigations have shed light on its pivotal role in governing cell fate,gene expression,and disease pathways.However,o...
supported by the National Key R&D Program of China(No.2017YFA0505400);the National Natural Science Foundation of China(Nos.21877024,21972214 and 22277020)。
Activity-based Ubiquitin probes(Ub-ABPs)carrying a reporter group have emerged as effective tools for the investigation of deubiquitinating enzymes(DUBs),such as studying the molecular mechanism of DUBs,profiling new ...
supported by Anhui Scientific and Technological Project(No.1704a0802164);the Natural Science Foundation of the Anhui Higher Education Institutions of China(No.KJ2018A0192)
Fluorogens with aggregation-induced emission (AIE) characteristics have recently been widely applied for studying biological events, and fluorogens with “smart” properties are especially desirable. Herein, we ration...
Supported by the National Natural Science Foundation of China(No. 81572082) and the Natural Science Foundation of Jilin Province, China(Nos.2011713, 20150414015GH, 20150204010YY).
The effect of the chelating agent 4,7-bis(chlorosulfophenyl)-1,10-phenanthroline-2,9-dicarboxylic acid (BCPDA) labeled hepatitis B surface antibodies(HBsAb) on time-resolved fluoroimmunoassays(TRFIA) was inves...
A switchable room-temperature phosphorescence(RTP) nanosensor based on an MPA-capped Mn-dopedZnS QDs/CTAB composite system(MPA=3-mercaptopropionic acid; CTAB=cetyltrimethyl ammonium bromide;QDs=quantum dots) was e...
The specific binding of receptor to ligand covalently attached to surface with different surface densities was studied using streptavidin-biotin model pair. Biotinylated substrates with different spacer thicknesses as...
Two biotinylated derivatives of the fungal metabolite galiellalactone (1) were synthesized in order to facilitate the investigation of the molecular mechanism of action of the galiellalactonoids. Galiellalactone is a ...
Supported by the National Natural Science Foundation of China(Nos.91123029, 61077066, 61340032), the National High Technology Research and Development Program of China(No.2012AA063302) and the Natural Science Foundation of Shandong Province, China(No.ZR2012CM029).
The sensing sensitivity of the wavelength interrogated surface plasmon resonance(WISPR) biosensor could be improved by self-assembly of nanoporous thin-film of TiO2 nanoparticles/DNA(TiO2/DNA)n(n is the number of...
Project supported by the National Natural Science Foundation of China (No. 20175002).
Study on biotinylation strategies for competitive immunoassay of estradiol (E2) was carried out. Two types of competitive enzyme immunoassay (EIA) with Biotin-Avidin amplification system were established and optimized...
ProjectsupportedbytheNationalNaturalScienceFoundationofChina (No .2 0 0 75 0 2 7)
Thiol terminated oligonucleotide was immobilized to gold surface by self assembly method. A novel amplification strategy was introduced for improving the sensitivity of DNA hybridization using biotin labeled protein...