PRODRUGS

作品数：67被引量：100H指数：5
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相关领域：医药卫生化学工程更多>>
相关作者：张礼和谢璐佳郭颖卢俊峰徐靖源更多>>
相关机构：中国医学科学院北京协和医学院北京大学香港城市大学天津医科大学更多>>
相关期刊：《Nano-Micro Letters》《Chinese Journal of Natural Medicines》《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》更多>>
相关基金：国家自然科学基金天津市自然科学基金中国博士后科学基金教育部留学回国人员科研启动基金更多>>
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An enzyme-gated bioorthogonal catalytic nanoreactor for tumor specific prodrug activation
《Nano Research》2025年第2期557-570,共14页Yuheng Guo Fang Jiang Xiaohui Zhu Wen He Sijie Song Xuecen Shou Mengnan Wu Ting Wu Tingjing Huang Zhi Ye Xuyang Wang Zhitong Chen Yu He Yuhang Yao Zhaowei Chen Huanghao Yang 
This work was funded by the National Key Research and Development Program of China(No.2020YFA0210800,H.H.Y.);the Major Project of Science and Technology of Fujian Province(No.2020HZ06006,H.H.Y.);the National Natural Science Foundation of China(Nos.22421002,22027805,and 22334004,H.H.Y.,Nos.22107019,and 22277011,Z.W.C.,No.22404025,Y.H.Y.);the Research project of General Administration of Customs of PRC(No.2024HK008,X.H.Z.).
Bioorthogonal catalysis mediated by abiotic transition metal catalysts(TMCs)is emerging as a momentum-gathering strategy for in situ generation of therapeutics.However,the unpredictable leakage and deposition of TMCs ...
关键词：bioorthogonal catalysis PRODRUGS enzyme-gated catalyst immobilization cancer therapy 
Erratum to:Balancing efficacy and safety of doxorubicin-loaded albumin nanoparticles utilizing pH-sensitive doxorubicin-fatty acid prodrugs
《Nano Research》2024年第7期6774-6775,共2页Yuanhao Yu Shiyi Zuo Jiaxuan Song Lingxiao Li Tian Liu Jiayu Guo Yaqiao Li Danping Wang Qi Lu Helin Wang Dun Zhou Zhonggui He Xiaohong Liu Bingjun Sun Jin Sun 
The Hoechst and DOX tunnel images of the DOX-C_(22) ANPs group at 4 h in Fig.4(a)were mistakenly used with the neighboring images of DOX-C_(26) ANPs group.The images were corrected as follows to be correspondence with...
关键词：group. utilizing loaded 
Balancing efficacy and safety of doxorubicin-loaded albumin nanoparticles utilizing pH-sensitive doxorubicin-fatty acid prodrugs
《Nano Research》2024年第6期5491-5500,共10页Yuanhao Yu Shiyi Zuo Jiaxuan Song Lingxiao Li Tian Liu Jiayu Guo Yaqiao Li Danping Wang Qi Lu Helin Wang Dun Zhou Zhonggui He Xiaohong Liu Bingjun Sun Jin Sun 
the National Key R&D Program of China(No.2022YFE0111600);National Natural Science Foundation of China(Nos.82272151 and 82204318)。
Albumin nanoparticles(ANPs)offer unique advantages for antitumor drug delivery system,including non-immunogenicity and inherent tumor-targeting capacity.At present,only a few products,such as ABRAXANE®and FYARRO™,have...
关键词：fatty acid prodrug ALBUMIN DOXORUBICIN pH-sensitive bond NANOMEDICINES 
Cathepsin B-responsive prodrugs for cancer-targeted therapy:Recent advances and progress for clinical translation
《Nano Research》2022年第8期7247-7266,共20页Seong Ik Jeon Suah Yang Man Kyu Shim Kwangmeyung Kim 
the National Research Foundation of Korea(NRF)grant funded by the Korea government(Nos.NRF2019R1A2C3006283 and NRF-2021R1C1C2005460);the KUKIST Graduate School of Converging Science and Technology(Korea University&KIST);the Intramural Research Program of KIST.
The cathepsin B-responsive prodrugs are promising strategies to reduce the serious adverse effects of anticancer drugs by improving the cancer selectivity that can be specifically activated by overexpressed cathepsin ...
关键词：cathepsin B PRODRUG CHEMOTHERAPY drug delivery system targeted cancer therapy 
Photo-triggered nucleus targeting for cancer drug delivery被引量：2
《Nano Research》2021年第8期2630-2636,共7页Yafei Li Wen Lv Lang Wang Yarning Zhang Lipeng Yang Tianyi Wang Linyong Zhu Yufeng Wang Weiping Wang 
supported by the Research Grants Council of Hong Kong(Early Career Scheme,No.27115220);Ming Wai Lau Centre for Reparative Medicine Associate Member Program,and Young Scientists Fund of the National Natural Science Foundation of China(No.81803469);We thank Dr.Jenny Lam at The University of Hong Kong for providing the A549 cell line.We acknowledge the assistance of The University of Hong Kong Li Ka Shing Faculty of Medicine Faculty Core Facility.
Here,we report a strategy to deliver drug nanoparticles into cells with nucleus-targeting ability under a spatiotemporal control.The nanoparticles were constructed through self-assembly of photoresponsive prodrugs and...
关键词：phototargeting dePEGylation nucleus targeting COUMARIN photoresponsive prodrugs 
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