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ANTITUMOR: 作品数：470被引量：1206H指数：15; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：明艳林陈良华刘韶松齐宪荣李润涛更多>>; 相关机构：北京大学天津医科大学中国药科大学福建省亚热带植物研究所更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划北京市自然科学基金更多>>

An Efficient One-pot Synthesis of Certain Stereoselective Spiro[pyrazole-4,5′-isoxazoline]-5-one Derivatives:In vitro Evaluation of Antitumor Activities,Molecular Docking and In silico ADME Predictions被引量：1: 《Chemical Research in Chinese Universities》2022年第4期1073-1082,共10页Ghadah F.ALJOHANI Fatma A.A.EL-HAG Mohamed S.BEKHEIT Ewies F.EWIES May A.EL-MANAWATY; supported by the Fund of National Research Centre,Egypt.; Alibrary of novel spiro[pyrazole-4,5′-isoxazoline]-5-one derivatives were designed and synthesized using a concise and efficient one-pot reaction protocol through 1,3-dipolar cycloaddition between 4-benzylidene-3-met...; 关键词：Spiroisoxazoline PYRAZOLE Chlrooxime 1 3-Dipolar cycloaddition ANTITUMOR Molecular docking

Synthesis and Antitumor Activity of Sorafenib Analogs Containing a Tetrazole Moiety: 《Chemical Research in Chinese Universities》2019年第1期41-46,共6页TIAN Ye YU Simiao CAI Lude GONG Guowei WU Guodong QI Hongxia ZHAO Yanfang QIN Mingze; the National Natural Science Foundation of China(No.81502924).; A novel series of diaryl biuret derivatives containing a tetrazole moiety was designed and synthesized.All the target compounds were evaluated for their in vitro antitumor activity against HT-29,HepG2,MCF-7 and A549 c...; 关键词：SORAFENIB DERIVATIVE TETRAZOLE MOIETY ANTITUMOR activity

Design, Synthesis and Biological Evaluation of Novel Selective Thiol-based Histone Deacetylase（HDAC） Ⅵ Inhibitors Bearing Indeno[1,2-c]pyrazole or Benzoindazole Scaffold: 《Chemical Research in Chinese Universities》2018年第1期75-83,共9页XU Qihao YU Shujia CAI Yijun YANG Jinyu ZHAO Linxiang LIU Dan; Supported by the National Natural Science Foundation of China（No.81473086） and the Natural Science Foundation of Liaoning Province, China（No.2015020728 -301 ）.; A series of thiol-based mdeno[1,2-c]pyrazoles and benzoindazole compounds was designed and synthesized according to the structural specificity of his-tone deacetylase VI（HDAC6） and the structural characteristics of ...; 关键词：Histone deacetylase Ⅵ（HDAC6） selective inhibitor Indeno[1 2-c]pyrazole compound Benzoindazole compound ANTITUMOR

Synthesis, Antitumor Activity and Preliminary Structure-activity Relationship of 2-Aminothiazole Derivatives被引量：3: 《Chemical Research in Chinese Universities》2016年第6期929-937,共9页LI Hongshuang WANG Xinran DUAN Guiyun XIA Chengcai XIAO Yuliang LI Furong GE Yanqing YOU Guirong HAN Junfen FU Xiaopan; In this paper, we described the synthesis of 2-aminoflfiazole sublibrary containing methyl, bromo, phenylor butylidene at 4- or/and 5-position of its core. All target compounds were evaluated tbr their antitumor activ...; 关键词：2-Aminotlfiazole ANTITUMOR activity STRUCTURE-ACTIVITY RELATIONSHIP

Design, Synthesis and Antitumor Activity of Pyrrolopyrazinone-chalcone Hybrids: 《Chemical Research in Chinese Universities》2014年第4期624-631,共8页MENG Ying ZHANG Hongwei LIU Zehua ZENG Shanchao SUN Chiyu ZHANG Lijuan ZHAO Mingming WANG Guan JIANG Mengying SHI Wei SONG Hongrui; A series of pyrrolopyrazinone-chalcone hybrids（12a-12q） was designed,synthesized and screened for their antitumor activity against SKOV-3,A549 and HeLa cell lines in vitro.Compared with the pyrrolopyrazinone（10a） ...; 关键词：Pyrrolopyrazinone-chalcone hybrid ANTITUMOR Marine sponge Combination principle

Synthesis and Antitumor Activity of a New 7-Azaindole Derivative: 《Chemical Research in Chinese Universities》2014年第3期420-424,共5页ZHANG Peng SUI Dayun XU Huali SUN Weilun YU Xiaofeng QU Shaochun HU Jianbing WU Yi WANG Yingshi; We designed and synthesized a 7-azaindole derivative（TH1082）, which was characterized by 1^H NMR and 13^C-NMR. We investigated its antitumor effects on human melanoma A375 cells, human liver cancer SMMC cells and hu...; 关键词：7-Azaindole ANTITUMOR APOPTOSIS

Synthesis and Antitumor Activity of 2-[1-(2-Formylamido-3-phenylpropionyloxy)alkyl]-1,4dihydroxy-9,10-anthraquinone Derivatives: 《Chemical Research in Chinese Universities》2012年第6期971-975,共5页J1N Li-li JIN Guang-zhu; Supported by the National Natural Science Foundation of China(No.30360119); A series of 2-[1-（2-formylamido-3-phenylpropionyloxy）alkyl]-1,4-dihydroxy-9,10-anthraquinone（2FPADHAQ） derivatives was designed and synthesized.Their antitumor activities were tested against L1210 tumor cells and ...; 关键词：ANTHRAQUINONE ANTITUMOR CYTOTOXICITY PHENYLALANINE

Antitumor Active Protein-containing Glycans from the Body of Ganoderma tsugae: 《Chemical Research in Chinese Universities》2012年第3期449-453,共5页LIU Ying LI Yue-fei ZHENG Ke-yan FEI Xiao-fang; Supported by the National Natural Science Foundation of China(No.30870552); To explore the effects of traditional herbal medicine Ganoderrna tsugae（G, tsugae） on immunomodulatory and antitumor activities, the crude polysaccharides of G. tsugae were purified by filtration, diethylaminoethyl...; 关键词：Protein-containing glycan Ganoderma tsugae Antitumor activity

Induction of Effective Antitumor Immune Response by Combined Administration of hIL-18 and NDV HN: 《Chemical Research in Chinese Universities》2011年第5期836-840,共5页HUANG Hai-yan MENG Xiang-wei LI Xiao SUN Li-li KAN Shi-fu LIU Lei PIAO Bing-guo YANG Guo-hua WANG Zhuo-yue WANG Yu-hang QI Yan-xin JIN Ning-yi; Supported by the Genetically Modified Organisms Breeding Major Projects, China(No.2009ZX08006-002B);the Key Technologies Research and Development Program of Jilin Province, China(No.10ZDGG007);the Postdoctoral Science Foundation Funded Project of China(No.20100481057); To analyze the antitumor potential and mechanism of action of simultaneous Newcastle disease virus （NDV） hemagglutinin-neuraminidase（HN） and human interleukin 18（hIL-18） gene transfer in C57BL/6 mice with H22 he...; 关键词：Newcastle disease virus Human interleukin 18（hlL-18） Hemagglutinin-neuraminidase（HN） HEPATOMA Antitumor immunity

Development of NAMI-A-loaded PLGA-mPEG Nanoparticles:Physicochemical Characterization, in vitro Drug Release and in vivo Antitumor Efficacy: 《Chemical Research in Chinese Universities》2011年第3期345-349,共5页YANG Yong-guang LIU Du XIA Yu ZHOU Yan-hui ZHONG Xue-yun LIU Jie; Supported by the National Natural Science Foundation of China(No.20871056);the Planned Item of Science and Technology of Guangdong Province, China (No.C1011220800060);the "211" Project Grant of Jinan University.; NAMI-A[imidazolium trans-tetrachloro(dimethylsulfoxide)imidazoleruthenium(Ⅲ)] shows extraordinary activities against metastatic tumors. However, the hydrolysis of NAMI-A to produce dimethyl sulfoxide(DMSO) could redu...; 关键词：PLGA-mPEG nanoparticle NAMI-A Drug release Drug delivery ANTITUMOR

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