support:R01EB022018,R15HL140503,T32 HL134613 from NIH,UT STARS.
Cardiac extracellular matrices(ECM)play crucial functional roles in cardiac biomechanics.Previous studies have mainly focused on collagen,the major structural ECM in heart wall.The role of elastin in cardiac mechanics...
a subvention obtained from Biological Research Institute.Faculty of Medicine.Zulia University,the Council for Humanistic and Scientific Devel-opment of Zulia University(CONDES LUZ),and Castejón Foundation.The technical digital help of Lic.Orlando Caste-jón Depablos is deeply appreciated.The author declares no conflicts of interests.
Twenty one days old Swiss albino mice that received diphenylhydantoin(25 mg/kg,i.p.,daily for 15 days)progressively developed gait alterations,changes of behavior and cerebellar ataxia.Cerebellar slices were processed...
Ventricular fibrillation (VF) is a malignant arrhythmia, usually initiated by a ventricular premature contraction (VPC) during the vulnerable period of cardiac repolarization. Ablation therapy for VF has been desc...
Ephexin-1 functions as guanine nucleotide exchange factors for the Rho-type GTPases which have important roles in neuronal development including axon guidance, migration, morphogenesis, and plasticity of neurons. As l...
Benzodiazepine (BZD) is the most prescribed CNS depressant in America to treat hyper-excitatory disorders such as anxiety and insomnia. However, the chronic use of BZD often creates adverse effects including psychomot...
Supported by An Health Research Council-Japanese Society for the Promotion of Science fellowship and the Neurological Foundation of New Zealand(Empson RM and Nagaraja RY);a British Biological and Biotechnology Research Council award(Empson RM and Garside ML);a Department of Physiology MSc studentship(Huang H);RIKEN intramural funding(Knpfel T)
The cerebellum expresses one of the highest levels of the plasma membrane Ca2+ATPase,isoform 2 in the mammalian brain.This highly efficient plasma membrane calcium transporter protein is enriched within the main outpu...